38400

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) hicAB/HicA-HicB
Location 2542455..2543077 Replicon chromosome
Accession NZ_AP024342
Organism Pseudomonas sp. Eqa60

Toxin (Protein)


Gene name hicA Uniprot ID -
Locus tag KI242_RS11615 Protein ID WP_077935001.1
Coordinates 2542895..2543077 (-) Length 61 a.a.

Antitoxin (Protein)


Gene name hicB Uniprot ID -
Locus tag KI242_RS11610 Protein ID WP_077933771.1
Coordinates 2542455..2542856 (-) Length 134 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
KI242_RS11590 (PEQA60_23030) 2538515..2538871 - 357 WP_015634966.1 hypothetical protein -
KI242_RS11595 (PEQA60_23040) 2539139..2539570 + 432 WP_011060480.1 hypothetical protein -
KI242_RS11600 (PEQA60_23050) 2539791..2540180 - 390 WP_011060481.1 hypothetical protein -
KI242_RS11605 (PEQA60_23060) 2540667..2542292 + 1626 WP_212806163.1 methyl-accepting chemotaxis protein -
KI242_RS11610 (PEQA60_23070) 2542455..2542856 - 402 WP_077933771.1 type II toxin-antitoxin system HicB family antitoxin Antitoxin
KI242_RS11615 2542895..2543077 - 183 WP_077935001.1 type II toxin-antitoxin system HicA family toxin Toxin
KI242_RS11620 (PEQA60_23080) 2543220..2543918 - 699 WP_041117166.1 arsenical resistance protein ArsH -
KI242_RS11625 (PEQA60_23090) 2543928..2544398 - 471 WP_015634973.1 arsenate reductase ArsC -
KI242_RS11630 (PEQA60_23100) 2544427..2545710 - 1284 WP_212806164.1 arsenic transporter -
KI242_RS11635 (PEQA60_23110) 2545731..2546078 - 348 WP_015634975.1 metalloregulator ArsR/SmtB family transcription factor -
KI242_RS11640 (PEQA60_23120) 2546309..2546863 + 555 WP_212806165.1 hypothetical protein -
KI242_RS11645 (PEQA60_23130) 2547109..2547540 - 432 WP_011060488.1 carboxymuconolactone decarboxylase family protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

HicA mRNA interferase family

(6-59)

Antitoxin

HicB-like antitoxin of toxin-antitoxin system

(3-127)


Sequences

Toxin        


Download         Length: 61 a.a.        Molecular weight: 6798.01 Da        Isoelectric Point: 11.5631

>T38400 WP_077935001.1 NZ_AP024342:c2543077-2542895 [Pseudomonas sp. Eqa60]
VQSRLLIKELEAAGWVLERVTGSHHLFQHPYRPNTVPVPHPKKDLPRGTVRAIRKLAGLL

Download         Length: 183 bp

>T38400 NZ_AP024342:c2543077-2542895 [Pseudomonas sp. Eqa60]
GTGCAAAGCAGACTGTTGATCAAGGAGCTTGAAGCCGCAGGCTGGGTGCTGGAGCGAGTCACCGGCAGCCATCATCTGTT
CCAGCATCCCTACCGGCCCAACACCGTTCCCGTGCCGCATCCGAAGAAGGATCTGCCACGGGGAACGGTCCGGGCCATCA
GGAAACTGGCCGGGCTGCTCTAG

Antitoxin


Download         Length: 134 a.a.        Molecular weight: 14514.49 Da        Isoelectric Point: 5.1222

>AT38400 WP_077933771.1 NZ_AP024342:c2542856-2542455 [Pseudomonas sp. Eqa60]
VQYPICIEWGDEHTATGIQIPDIPGAVTAGDTFEAAYSAAVEIAHLMLEELARAGQAIPLPSATQTHRAHPDYQGMGWGM
LEIDITPYLGKTEKVNVTLPGYVIQQIDRFVRAHNIKSRSSFLADAALEKLGR

Download         Length: 402 bp

>AT38400 NZ_AP024342:c2542856-2542455 [Pseudomonas sp. Eqa60]
GTGCAATATCCCATCTGCATCGAGTGGGGCGACGAGCACACGGCCACCGGCATCCAGATTCCCGACATTCCCGGCGCGGT
CACCGCCGGCGACACCTTCGAGGCCGCCTACAGCGCCGCCGTCGAGATTGCCCACCTCATGCTCGAAGAGCTGGCCCGCG
CCGGGCAGGCCATTCCCCTGCCCTCTGCCACCCAAACGCACCGCGCCCATCCTGATTACCAGGGGATGGGCTGGGGCATG
CTGGAGATCGACATCACGCCTTACCTGGGCAAGACCGAGAAGGTCAACGTGACCTTGCCGGGGTACGTGATTCAGCAGAT
CGACCGCTTTGTCCGAGCGCACAACATCAAGAGCCGGTCGTCCTTTCTGGCGGATGCGGCGCTGGAAAAGCTCGGGCGCT
AA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References