Detailed information of TA system TA038399

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): relBE/RHH(antitoxin)
• Location: 1053917..1054455
• Replicon: chromosome
• Accession: NZ_AP024342
• Organism: Pseudomonas sp. Eqa60

Toxin (Protein)

• Gene name: relE
• Uniprot ID: -
• Locus tag: KI242_RS04615
• Protein ID: WP_072443006.1
• Coordinates: 1054177..1054455 (+)
• Length: 93 a.a.

Antitoxin (Protein)

• Gene name: relB
• Uniprot ID: A0A7U9L9U0
• Locus tag: KI242_RS04610
• Protein ID: WP_047283908.1
• Coordinates: 1053917..1054180 (+)
• Length: 88 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
KI242_RS31665	1049519..1049674	-	156	Protein_903	hypothetical protein	-
KI242_RS04595 (PEQA60_09060)	1049900..1052185	-	2286	WP_053149024.1	TonB-dependent siderophore receptor	-
KI242_RS04600 (PEQA60_09070)	1052392..1053072	+	681	WP_011059221.1	Fe2+-dependent dioxygenase	-
KI242_RS04605 (PEQA60_09080)	1053076..1053861	+	786	WP_077933345.1	tetratricopeptide repeat protein	-
KI242_RS04610 (PEQA60_09090)	1053917..1054180	+	264	WP_047283908.1	ribbon-helix-helix domain-containing protein	Antitoxin
KI242_RS04615	1054177..1054455	+	279	WP_072443006.1	type II toxin-antitoxin system RelE/ParE family toxin	Toxin
KI242_RS04620 (PEQA60_09100)	1054526..1055689	-	1164	WP_015634137.1	type III PLP-dependent enzyme	-
KI242_RS04625 (PEQA60_09110)	1056368..1057525	-	1158	WP_015634138.1	ABC transporter ATP-binding protein	-
KI242_RS04630 (PEQA60_09120)	1057522..1058175	-	654	WP_011059225.1	ABC transporter permease	-
KI242_RS04635 (PEQA60_09130)	1058188..1059081	-	894	WP_015634139.1	glycine betaine ABC transporter substrate-binding protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin-antitoxin system, RelE/ParE toxin family (4-91)

Antitoxin

• Ribbon-helix-helix protein, CopG (7-44)

Sequences

Toxin

Protein

• Length: 93 a.a.
• Molecular weight: 10793.48 Da
• Isoelectric Point: 10.6604

>T38399 WP_072443006.1 NZ_AP024342:1054177-1054455 [Pseudomonas sp. Eqa60]
MRQLKWTSKALSDLARLFEFLAQANRSTAARTVQSLVQAPDALLSNPRLGEQLEEFKPRDVRRLLVGHYEMRYEIQGMAL
SILRIWHVREDR

Nucleotide

• Length: 279 bp

>T38399 NZ_AP024342:1054177-1054455 [Pseudomonas sp. Eqa60]
ATGAGACAGCTGAAATGGACGAGCAAGGCCCTATCCGATCTGGCTCGGCTTTTTGAGTTTCTCGCCCAGGCCAATCGTTC
TACTGCTGCTCGGACCGTGCAATCGCTGGTGCAGGCTCCAGATGCTCTTCTATCTAACCCACGATTGGGAGAGCAGTTGG
AGGAATTCAAGCCGAGGGATGTTCGACGATTGCTGGTGGGGCATTACGAGATGCGTTATGAGATTCAAGGCATGGCCTTG
TCCATCCTGCGTATTTGGCATGTCCGGGAAGATCGTTGA

Antitoxin

Protein

• Length: 88 a.a.
• Molecular weight: 9676.08 Da
• Isoelectric Point: 5.6706

>AT38399 WP_047283908.1 NZ_AP024342:1053917-1054180 [Pseudomonas sp. Eqa60]
MPATKVLTAHIPLDLADKVDQLASRLERSRAWVVKQALVAWVDQEEERRRLTLEALADVDAGRVVDHQSVLAWAQSLSGD
NPLPLPK

Nucleotide

• Length: 264 bp

>AT38399 NZ_AP024342:1053917-1054180 [Pseudomonas sp. Eqa60]
ATGCCCGCGACAAAAGTACTGACCGCTCACATTCCCTTGGACCTGGCTGACAAGGTCGATCAACTTGCTTCTCGCCTGGA
ACGCTCCCGGGCCTGGGTCGTGAAGCAGGCGTTGGTGGCCTGGGTTGACCAGGAAGAAGAGCGCCGTCGACTGACGCTTG
AGGCCTTGGCAGATGTCGATGCTGGAAGGGTTGTGGATCATCAGTCAGTGTTGGCTTGGGCGCAGAGTCTGTCTGGCGAC
AACCCTCTGCCCTTACCAAAATGA

Structures

Antitoxin

• AlphaFold DB: A0A7U9L9U0