Detailed information of TA system TA038397

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): relBE/ParE-YafN
• Location: 181050..181566
• Replicon: chromosome
• Accession: NZ_AP024342
• Organism: Pseudomonas sp. Eqa60

Toxin (Protein)

• Gene name: relE
• Uniprot ID: -
• Locus tag: KI242_RS00800
• Protein ID: WP_103740982.1
• Coordinates: 181285..181566 (+)
• Length: 94 a.a.

Antitoxin (Protein)

• Gene name: relB
• Uniprot ID: Q4KKD3
• Locus tag: KI242_RS00795
• Protein ID: WP_011058534.1
• Coordinates: 181050..181295 (+)
• Length: 82 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
KI242_RS00780 (PEQA60_01550)	178544..180154	+	1611	WP_212805832.1	glycosyltransferase family 39 protein	-
KI242_RS00785 (PEQA60_01560)	180264..180725	+	462	WP_011058532.1	YbaK/EbsC family protein	-
KI242_RS00790 (PEQA60_01570)	180740..180985	+	246	WP_212805833.1	DUF2789 domain-containing protein	-
KI242_RS00795 (PEQA60_01580)	181050..181295	+	246	WP_011058534.1	type II toxin-antitoxin system Phd/YefM family antitoxin	Antitoxin
KI242_RS00800 (PEQA60_01590)	181285..181566	+	282	WP_103740982.1	type II toxin-antitoxin system RelE/ParE family toxin	Toxin
KI242_RS00805 (PEQA60_01600)	181709..182137	+	429	WP_011058536.1	winged helix DNA-binding protein	-
KI242_RS00810 (PEQA60_01610)	182134..184221	+	2088	WP_041751900.1	FUSC family protein	-
KI242_RS00815 (PEQA60_01620)	184218..184427	+	210	WP_011058538.1	DUF1656 domain-containing protein	-
KI242_RS00820 (PEQA60_01630)	184424..185314	+	891	WP_011058539.1	HlyD family secretion protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin-antitoxin system, RelE/ParE toxin family (5-83)

Antitoxin

• Type II toxin-antitoxin system, antitoxin Phd/YefM (8-69)

Sequences

Toxin

Protein

• Length: 94 a.a.
• Molecular weight: 10812.70 Da
• Isoelectric Point: 10.2298

>T38397 WP_103740982.1 NZ_AP024342:181285-181566 [Pseudomonas sp. Eqa60]
MTYSLEFLPSAHKEWSKLGHTLREQFKKKLAERLEVPRIPADALHGLPDCYKIKLKASGYRLVYQVIEERVVVCVVAVGK
RERGTVYEQARKR

Nucleotide

• Length: 282 bp

>T38397 NZ_AP024342:181285-181566 [Pseudomonas sp. Eqa60]
ATGACTTATAGCCTTGAGTTCCTGCCTTCGGCACACAAGGAATGGAGCAAGTTGGGGCATACGCTTCGAGAGCAATTCAA
GAAAAAGCTCGCCGAACGGCTTGAGGTGCCGCGAATCCCTGCTGATGCCCTGCATGGGCTTCCCGATTGCTACAAAATTA
AACTCAAGGCTTCGGGCTACCGATTGGTTTATCAAGTGATCGAAGAGCGCGTCGTGGTTTGCGTGGTTGCGGTCGGCAAG
CGCGAGCGTGGAACCGTTTACGAGCAGGCCAGGAAACGCTGA

Antitoxin

Protein

• Length: 82 a.a.
• Molecular weight: 8799.10 Da
• Isoelectric Point: 4.3988

>AT38397 WP_011058534.1 NZ_AP024342:181050-181295 [Pseudomonas sp. Eqa60]
MQSILADKAVSVSELKKNPSAVLSGAQGGPVAVLNHNRVMGYMVPAEVFEALMERLDDLELAEIIRERSHETPVPVSLDD
L

Nucleotide

• Length: 246 bp

>AT38397 NZ_AP024342:181050-181295 [Pseudomonas sp. Eqa60]
ATGCAGAGTATTCTGGCTGACAAAGCCGTCAGCGTATCTGAGTTGAAGAAAAACCCTTCTGCCGTCTTGAGTGGTGCCCA
GGGCGGGCCAGTGGCGGTGTTGAATCACAATCGTGTCATGGGCTACATGGTTCCGGCCGAGGTTTTCGAAGCGTTGATGG
AACGCCTGGATGATCTGGAGTTGGCCGAAATCATCCGCGAGCGCAGCCATGAGACGCCCGTTCCGGTCAGTCTGGATGAC
TTATAG

Structures

Antitoxin

• AlphaFold DB: Q4KKD3