Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) TsdAT/-
Location 2091418..2091932 Replicon chromosome
Accession NZ_AP024318
Organism Staphylococcus aureus strain S36

Toxin (Protein)


Gene name TsdT Uniprot ID T1YA99
Locus tag K5606_RS10260 Protein ID WP_000581792.1
Coordinates 2091418..2091627 (-) Length 70 a.a.

Antitoxin (Protein)


Gene name TsdA Uniprot ID W8UW13
Locus tag K5606_RS10265 Protein ID WP_000138932.1
Coordinates 2091639..2091932 (-) Length 98 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
K5606_RS10240 (2086929) 2086929..2088284 - 1356 WP_000611457.1 UDP-N-acetylmuramoyl-tripeptide--D-alanyl-D- alanine ligase -
K5606_RS10245 (2088299) 2088299..2089369 - 1071 WP_000159641.1 D-alanine--D-alanine ligase -
K5606_RS10250 (2089687) 2089687..2090889 + 1203 WP_001109939.1 FtsW/RodA/SpoVE family cell cycle protein -
K5606_RS10255 (2091153) 2091153..2091290 - 138 WP_000828354.1 Lmo0850 family protein -
K5606_RS10260 (2091418) 2091418..2091627 - 210 WP_000581792.1 heavy metal-associated domain-containing protein Toxin
K5606_RS10265 (2091639) 2091639..2091932 - 294 WP_000138932.1 copper-sensing transcriptional repressor CsoR Antitoxin
K5606_RS10270 (2092098) 2092098..2093582 + 1485 WP_000571550.1 cardiolipin synthase -
K5606_RS10275 (2093610) 2093610..2094257 + 648 WP_001187614.1 HD domain-containing protein -
K5606_RS13740 (2094814) 2094814..2094876 + 63 Protein_1993 hypothetical protein -
K5606_RS10285 (2094854) 2094854..2096169 - 1316 Protein_1994 ISL3 family transposase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Heavy metal-associated domain, HMA

(23-66)

Antitoxin

Metal-sensitive transcriptional repressor

(14-92)


Sequences

Toxin        


Download         Length: 70 a.a.        Molecular weight: 7843.77 Da        Isoelectric Point: 4.1008

>T38363 WP_000581792.1 NZ_AP024318:c2091627-2091418 [Staphylococcus aureus]
MIHQNTIYTAGIETEEQVSQLTERISNMIGVHQVNINIIDGQVTVSYETPANLNSIEKEIYDEGYKIVF

Download         Length: 210 bp

>T38363 NZ_AP024318:c2091627-2091418 [Staphylococcus aureus]
ATGATACATCAAAATACGATTTACACAGCGGGAATTGAAACAGAAGAACAAGTAAGTCAATTGACAGAACGCATTTCAAA
TATGATAGGTGTTCATCAAGTGAATATTAATATAATTGATGGTCAAGTAACGGTATCGTATGAGACACCAGCAAATTTGA
ATAGTATTGAAAAAGAAATTTATGATGAAGGATACAAAATTGTATTTTAG

Antitoxin


Download         Length: 98 a.a.        Molecular weight: 11197.82 Da        Isoelectric Point: 6.2243

>AT38363 WP_000138932.1 NZ_AP024318:c2091932-2091639 [Staphylococcus aureus]
MTEQDNAHHSEQIKTNLKSRLNRIEGQVRAINRMIEEDVYCDDVLTQIRATRSALNSVAIKLLEQHMKSCIMNKVNQGAQ
EEAMEELLVTFQKLIKD

Download         Length: 294 bp

>AT38363 NZ_AP024318:c2091932-2091639 [Staphylococcus aureus]
ATGACTGAACAAGATAATGCACATCATTCTGAACAAATAAAAACGAATCTTAAATCACGTTTAAATCGAATTGAAGGACA
AGTGAGAGCGATTAATCGCATGATTGAAGAAGATGTCTATTGTGATGATGTCCTTACGCAAATAAGAGCGACACGTTCGG
CGTTAAACAGTGTTGCGATAAAGTTATTAGAACAACATATGAAAAGTTGTATTATGAATAAAGTTAATCAAGGAGCTCAG
GAAGAGGCAATGGAAGAGTTATTAGTGACTTTTCAAAAATTGATTAAAGACTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 6FF1

Antitoxin

Source ID Structure
AlphaFold DB W8UW13

References