Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) TsaAT/-
Location 809401..809877 Replicon chromosome
Accession NZ_AP024318
Organism Staphylococcus aureus strain S36

Toxin (Protein)


Gene name TsaT Uniprot ID T1Y7S2
Locus tag K5606_RS03775 Protein ID WP_000052076.1
Coordinates 809401..809589 (-) Length 63 a.a.

Antitoxin (Protein)


Gene name TsaA Uniprot ID T1Y6P8
Locus tag K5606_RS03780 Protein ID WP_001059690.1
Coordinates 809617..809877 (-) Length 87 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
K5606_RS03745 (805429) 805429..805911 + 483 WP_000824489.1 hypothetical protein -
K5606_RS03750 (806252) 806252..806938 + 687 WP_001574556.1 thermonuclease family protein -
K5606_RS03755 (807295) 807295..807495 + 201 WP_001059082.1 cold-shock protein -
K5606_RS03760 (807992) 807992..808210 - 219 WP_000005881.1 hypothetical protein -
K5606_RS03765 (808271) 808271..808555 - 285 WP_001004403.1 hypothetical protein -
K5606_RS03770 (808643) 808643..809212 - 570 WP_001106655.1 lipoprotein N-acylation protein LnsA -
K5606_RS03775 (809401) 809401..809589 - 189 WP_000052076.1 hypothetical protein Toxin
K5606_RS03780 (809617) 809617..809877 - 261 WP_001059690.1 hypothetical protein Antitoxin
K5606_RS03785 (810219) 810219..810422 + 204 WP_000145163.1 sterile alpha motif-like domain-containing protein -
K5606_RS03790 (810419) 810419..810655 - 237 WP_000368687.1 hypothetical protein -
K5606_RS03795 (810880) 810880..811461 + 582 WP_001140696.1 histidine phosphatase family protein -
K5606_RS03800 (811534) 811534..812151 - 618 WP_000255562.1 LysE/ArgO family amino acid transporter -
K5606_RS03805 (812300) 812300..812794 - 495 WP_000569881.1 GNAT family N-acetyltransferase -
K5606_RS03810 (813193) 813193..813615 - 423 WP_000974452.1 organic hydroperoxide resistance protein -
K5606_RS03815 (813763) 813763..814479 + 717 WP_000150026.1 type I 3-dehydroquinate dehydratase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

mRNA interferase PemK-like

(8-114)

Antitoxin

SpoVT-AbrB domain

(6-49)


Sequences

Toxin        


Download         Length: 63 a.a.        Molecular weight: 7142.82 Da        Isoelectric Point: 9.9971

>T38356 WP_000052076.1 NZ_AP024318:c809589-809401 [Staphylococcus aureus]
MSLHFAILFWLALIFLVAATFILVLMKKTGKESKKESYLSFTVILYIFGFAILIYTFIFGVL

Download         Length: 189 bp

>T38356 NZ_AP024318:c809589-809401 [Staphylococcus aureus]
ATGTCTTTACATTTTGCAATTCTGTTTTGGCTAGCATTAATTTTCTTAGTTGCCGCTACGTTTATACTCGTATTAATGAA
AAAAACTGGCAAAGAATCTAAAAAAGAGTCCTATTTAAGTTTCACTGTCATTCTCTATATTTTTGGATTCGCTATATTAA
TATACACATTTATATTTGGTGTGCTATAA

Antitoxin


Download         Length: 87 a.a.        Molecular weight: 9940.09 Da        Isoelectric Point: 4.0624

>AT38356 WP_001059690.1 NZ_AP024318:c809877-809617 [Staphylococcus aureus]
MNNILLNAINIVITTTFVIFNILITYNKDLDDLCWLLPGIIICGVILIVSFTIAMITKNWLSEILFFINIVLVLYYIYPI
FYSFIG

Download         Length: 261 bp

>AT38356 NZ_AP024318:c809877-809617 [Staphylococcus aureus]
ATGAATAACATTTTGTTAAATGCTATCAATATAGTTATTACTACCACTTTTGTTATCTTTAATATTTTAATCACATATAA
TAAAGATTTAGATGATTTATGTTGGCTCCTGCCTGGTATTATCATTTGTGGTGTGATACTCATAGTATCCTTTACCATTG
CAATGATAACTAAAAACTGGTTAAGTGAAATATTATTTTTTATAAATATCGTACTCGTTCTCTATTACATTTATCCTATT
TTTTATAGTTTTATAGGTTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0E0VP18

Antitoxin

Source ID Structure
AlphaFold DB A0A0E0VN56

References