Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) TsdAT/-
Location 2123630..2124144 Replicon chromosome
Accession NZ_AP024315
Organism Staphylococcus aureus strain BDH17

Toxin (Protein)


Gene name TsdT Uniprot ID T1YA99
Locus tag K5602_RS10395 Protein ID WP_000581792.1
Coordinates 2123630..2123839 (-) Length 70 a.a.

Antitoxin (Protein)


Gene name TsdA Uniprot ID W8UW13
Locus tag K5602_RS10400 Protein ID WP_000138932.1
Coordinates 2123851..2124144 (-) Length 98 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
K5602_RS10375 (2119141) 2119141..2120496 - 1356 WP_000611457.1 UDP-N-acetylmuramoyl-tripeptide--D-alanyl-D- alanine ligase -
K5602_RS10380 (2120511) 2120511..2121581 - 1071 WP_000159641.1 D-alanine--D-alanine ligase -
K5602_RS10385 (2121899) 2121899..2123101 + 1203 WP_001109939.1 FtsW/RodA/SpoVE family cell cycle protein -
K5602_RS10390 (2123365) 2123365..2123502 - 138 WP_000828354.1 Lmo0850 family protein -
K5602_RS10395 (2123630) 2123630..2123839 - 210 WP_000581792.1 heavy metal-associated domain-containing protein Toxin
K5602_RS10400 (2123851) 2123851..2124144 - 294 WP_000138932.1 copper-sensing transcriptional repressor CsoR Antitoxin
K5602_RS10405 (2124310) 2124310..2125794 + 1485 WP_000571550.1 cardiolipin synthase -
K5602_RS10410 (2125822) 2125822..2126469 + 648 WP_001187614.1 HD domain-containing protein -
K5602_RS13885 (2127026) 2127026..2127088 + 63 Protein_2020 hypothetical protein -
K5602_RS10420 (2127066) 2127066..2128381 - 1316 Protein_2021 ISL3 family transposase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Heavy metal-associated domain, HMA

(23-66)

Antitoxin

Metal-sensitive transcriptional repressor

(14-92)


Sequences

Toxin        


Download         Length: 70 a.a.        Molecular weight: 7843.77 Da        Isoelectric Point: 4.1008

>T38351 WP_000581792.1 NZ_AP024315:c2123839-2123630 [Staphylococcus aureus]
MIHQNTIYTAGIETEEQVSQLTERISNMIGVHQVNINIIDGQVTVSYETPANLNSIEKEIYDEGYKIVF

Download         Length: 210 bp

>T38351 NZ_AP024315:c2123839-2123630 [Staphylococcus aureus]
ATGATACATCAAAATACGATTTACACAGCGGGAATTGAAACAGAAGAACAAGTAAGTCAATTGACAGAACGCATTTCAAA
TATGATAGGTGTTCATCAAGTGAATATTAATATAATTGATGGTCAAGTAACGGTATCGTATGAGACACCAGCAAATTTGA
ATAGTATTGAAAAAGAAATTTATGATGAAGGATACAAAATTGTATTTTAG

Antitoxin


Download         Length: 98 a.a.        Molecular weight: 11197.82 Da        Isoelectric Point: 6.2243

>AT38351 WP_000138932.1 NZ_AP024315:c2124144-2123851 [Staphylococcus aureus]
MTEQDNAHHSEQIKTNLKSRLNRIEGQVRAINRMIEEDVYCDDVLTQIRATRSALNSVAIKLLEQHMKSCIMNKVNQGAQ
EEAMEELLVTFQKLIKD

Download         Length: 294 bp

>AT38351 NZ_AP024315:c2124144-2123851 [Staphylococcus aureus]
ATGACTGAACAAGATAATGCACATCATTCTGAACAAATAAAAACGAATCTTAAATCACGTTTAAATCGAATTGAAGGACA
AGTGAGAGCGATTAATCGCATGATTGAAGAAGATGTCTATTGTGATGATGTCCTTACGCAAATAAGAGCGACACGTTCGG
CGTTAAACAGTGTTGCGATAAAGTTATTAGAACAACATATGAAAAGTTGTATTATGAATAAAGTTAATCAAGGAGCTCAG
GAAGAGGCAATGGAAGAGTTATTAGTGACTTTTCAAAAATTGATTAAAGACTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 6FF1

Antitoxin

Source ID Structure
AlphaFold DB W8UW13

References