Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) TsaAT/-
Location 842950..843426 Replicon chromosome
Accession NZ_AP024315
Organism Staphylococcus aureus strain BDH17

Toxin (Protein)


Gene name TsaT Uniprot ID T1Y7S2
Locus tag K5602_RS03920 Protein ID WP_000052076.1
Coordinates 842950..843138 (-) Length 63 a.a.

Antitoxin (Protein)


Gene name TsaA Uniprot ID T1Y6P8
Locus tag K5602_RS03925 Protein ID WP_001059690.1
Coordinates 843166..843426 (-) Length 87 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
K5602_RS03890 (838978) 838978..839460 + 483 WP_000824489.1 hypothetical protein -
K5602_RS03895 (839801) 839801..840487 + 687 WP_001574556.1 thermonuclease family protein -
K5602_RS03900 (840844) 840844..841044 + 201 WP_001059082.1 cold-shock protein -
K5602_RS03905 (841541) 841541..841759 - 219 WP_000005881.1 hypothetical protein -
K5602_RS03910 (841820) 841820..842104 - 285 WP_001004403.1 hypothetical protein -
K5602_RS03915 (842192) 842192..842761 - 570 WP_001106655.1 lipoprotein N-acylation protein LnsA -
K5602_RS03920 (842950) 842950..843138 - 189 WP_000052076.1 hypothetical protein Toxin
K5602_RS03925 (843166) 843166..843426 - 261 WP_001059690.1 hypothetical protein Antitoxin
K5602_RS03930 (843768) 843768..843971 + 204 WP_000145163.1 sterile alpha motif-like domain-containing protein -
K5602_RS03935 (843968) 843968..844204 - 237 WP_000368687.1 hypothetical protein -
K5602_RS03940 (844429) 844429..845010 + 582 WP_001140696.1 histidine phosphatase family protein -
K5602_RS03945 (845083) 845083..845700 - 618 WP_000255562.1 LysE/ArgO family amino acid transporter -
K5602_RS03950 (845849) 845849..846343 - 495 WP_000569881.1 GNAT family N-acetyltransferase -
K5602_RS03955 (846742) 846742..847164 - 423 WP_000974452.1 organic hydroperoxide resistance protein -
K5602_RS03960 (847312) 847312..848028 + 717 WP_000150026.1 type I 3-dehydroquinate dehydratase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Hok/gef cell toxic protein

(6-47)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 63 a.a.        Molecular weight: 7142.82 Da        Isoelectric Point: 9.9971

>T38344 WP_000052076.1 NZ_AP024315:c843138-842950 [Staphylococcus aureus]
MSLHFAILFWLALIFLVAATFILVLMKKTGKESKKESYLSFTVILYIFGFAILIYTFIFGVL

Download         Length: 189 bp

>T38344 NZ_AP024315:c843138-842950 [Staphylococcus aureus]
ATGTCTTTACATTTTGCAATTCTGTTTTGGCTAGCATTAATTTTCTTAGTTGCCGCTACGTTTATACTCGTATTAATGAA
AAAAACTGGCAAAGAATCTAAAAAAGAGTCCTATTTAAGTTTCACTGTCATTCTCTATATTTTTGGATTCGCTATATTAA
TATACACATTTATATTTGGTGTGCTATAA

Antitoxin


Download         Length: 87 a.a.        Molecular weight: 9940.09 Da        Isoelectric Point: 4.0624

>AT38344 WP_001059690.1 NZ_AP024315:c843426-843166 [Staphylococcus aureus]
MNNILLNAINIVITTTFVIFNILITYNKDLDDLCWLLPGIIICGVILIVSFTIAMITKNWLSEILFFINIVLVLYYIYPI
FYSFIG

Download         Length: 261 bp

>AT38344 NZ_AP024315:c843426-843166 [Staphylococcus aureus]
ATGAATAACATTTTGTTAAATGCTATCAATATAGTTATTACTACCACTTTTGTTATCTTTAATATTTTAATCACATATAA
TAAAGATTTAGATGATTTATGTTGGCTCCTGCCTGGTATTATCATTTGTGGTGTGATACTCATAGTATCCTTTACCATTG
CAATGATAACTAAAAACTGGTTAAGTGAAATATTATTTTTTATAAATATCGTACTCGTTCTCTATTACATTTATCCTATT
TTTTATAGTTTTATAGGTTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0E0VP18

Antitoxin

Source ID Structure
AlphaFold DB A0A0E0VN56

References