Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) TsaAT/-
Location 887214..887690 Replicon chromosome
Accession NZ_AP024313
Organism Staphylococcus aureus strain N1195

Toxin (Protein)


Gene name TsaT Uniprot ID T1Y7S2
Locus tag K5605_RS04265 Protein ID WP_000052076.1
Coordinates 887214..887402 (-) Length 63 a.a.

Antitoxin (Protein)


Gene name TsaA Uniprot ID T1Y6P8
Locus tag K5605_RS04270 Protein ID WP_001059690.1
Coordinates 887430..887690 (-) Length 87 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
K5605_RS04235 (883242) 883242..883724 + 483 WP_000824489.1 hypothetical protein -
K5605_RS04240 (884065) 884065..884751 + 687 WP_001574556.1 thermonuclease family protein -
K5605_RS04245 (885108) 885108..885308 + 201 WP_001059082.1 cold-shock protein -
K5605_RS04250 (885805) 885805..886023 - 219 WP_000005881.1 hypothetical protein -
K5605_RS04255 (886084) 886084..886368 - 285 WP_001004403.1 hypothetical protein -
K5605_RS04260 (886456) 886456..887025 - 570 WP_001106655.1 lipoprotein N-acylation protein LnsA -
K5605_RS04265 (887214) 887214..887402 - 189 WP_000052076.1 hypothetical protein Toxin
K5605_RS04270 (887430) 887430..887690 - 261 WP_001059690.1 hypothetical protein Antitoxin
K5605_RS04275 (888032) 888032..888235 + 204 WP_000145163.1 sterile alpha motif-like domain-containing protein -
K5605_RS04280 (888232) 888232..888468 - 237 WP_000368687.1 hypothetical protein -
K5605_RS04285 (888693) 888693..889274 + 582 WP_001140696.1 histidine phosphatase family protein -
K5605_RS04290 (889412) 889412..890584 - 1173 WP_000195429.1 IS256-like element IS256 family transposase -
K5605_RS04295 (890670) 890670..891296 - 627 WP_221046808.1 LysE/ArgO family amino acid transporter -
K5605_RS04300 (891445) 891445..891939 - 495 WP_000569881.1 GNAT family N-acetyltransferase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- flank IS/Tn - - 889412..890584 1172


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin CcdB

(2-100)

Antitoxin

Post-segregation antitoxin CcdA

(2-72)


Sequences

Toxin        


Download         Length: 63 a.a.        Molecular weight: 7142.82 Da        Isoelectric Point: 9.9971

>T38332 WP_000052076.1 NZ_AP024313:c887402-887214 [Staphylococcus aureus]
MSLHFAILFWLALIFLVAATFILVLMKKTGKESKKESYLSFTVILYIFGFAILIYTFIFGVL

Download         Length: 189 bp

>T38332 NZ_AP024313:c887402-887214 [Staphylococcus aureus]
ATGTCTTTACATTTTGCAATTCTGTTTTGGCTAGCATTAATTTTCTTAGTTGCCGCTACGTTTATACTCGTATTAATGAA
AAAAACTGGCAAAGAATCTAAAAAAGAGTCCTATTTAAGTTTCACTGTCATTCTCTATATTTTTGGATTCGCTATATTAA
TATACACATTTATATTTGGTGTGCTATAA

Antitoxin


Download         Length: 87 a.a.        Molecular weight: 9940.09 Da        Isoelectric Point: 4.0624

>AT38332 WP_001059690.1 NZ_AP024313:c887690-887430 [Staphylococcus aureus]
MNNILLNAINIVITTTFVIFNILITYNKDLDDLCWLLPGIIICGVILIVSFTIAMITKNWLSEILFFINIVLVLYYIYPI
FYSFIG

Download         Length: 261 bp

>AT38332 NZ_AP024313:c887690-887430 [Staphylococcus aureus]
ATGAATAACATTTTGTTAAATGCTATCAATATAGTTATTACTACCACTTTTGTTATCTTTAATATTTTAATCACATATAA
TAAAGATTTAGATGATTTATGTTGGCTCCTGCCTGGTATTATCATTTGTGGTGTGATACTCATAGTATCCTTTACCATTG
CAATGATAACTAAAAACTGGTTAAGTGAAATATTATTTTTTATAAATATCGTACTCGTTCTCTATTACATTTATCCTATT
TTTTATAGTTTTATAGGTTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0E0VP18

Antitoxin

Source ID Structure
AlphaFold DB A0A0E0VN56

References