Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) TsdAT/-
Location 2188444..2188958 Replicon chromosome
Accession NZ_AP024311
Organism Staphylococcus aureus strain THI2018-120

Toxin (Protein)


Gene name TsdT Uniprot ID T1YA99
Locus tag ST1232TP_RS10840 Protein ID WP_000581792.1
Coordinates 2188444..2188653 (-) Length 70 a.a.

Antitoxin (Protein)


Gene name TsdA Uniprot ID W8UW13
Locus tag ST1232TP_RS10845 Protein ID WP_000138932.1
Coordinates 2188665..2188958 (-) Length 98 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
ST1232TP_RS10820 (2183955) 2183955..2185310 - 1356 WP_221046795.1 UDP-N-acetylmuramoyl-tripeptide--D-alanyl-D- alanine ligase -
ST1232TP_RS10825 (2185325) 2185325..2186395 - 1071 WP_000159641.1 D-alanine--D-alanine ligase -
ST1232TP_RS10830 (2186713) 2186713..2187915 + 1203 WP_001109939.1 FtsW/RodA/SpoVE family cell cycle protein -
ST1232TP_RS10835 (2188179) 2188179..2188316 - 138 WP_000828354.1 Lmo0850 family protein -
ST1232TP_RS10840 (2188444) 2188444..2188653 - 210 WP_000581792.1 heavy metal-associated domain-containing protein Toxin
ST1232TP_RS10845 (2188665) 2188665..2188958 - 294 WP_000138932.1 copper-sensing transcriptional repressor CsoR Antitoxin
ST1232TP_RS10850 (2189124) 2189124..2190608 + 1485 WP_000571550.1 cardiolipin synthase -
ST1232TP_RS10855 (2190636) 2190636..2191283 + 648 WP_001187614.1 HD domain-containing protein -
ST1232TP_RS14225 (2191840) 2191840..2191902 + 63 Protein_2112 hypothetical protein -
ST1232TP_RS10865 (2191880) 2191880..2193195 - 1316 Protein_2113 ISL3 family transposase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Heavy metal-associated domain, HMA

(23-66)

Antitoxin

Metal-sensitive transcriptional repressor

(14-92)


Sequences

Toxin        


Download         Length: 70 a.a.        Molecular weight: 7843.77 Da        Isoelectric Point: 4.1008

>T38327 WP_000581792.1 NZ_AP024311:c2188653-2188444 [Staphylococcus aureus]
MIHQNTIYTAGIETEEQVSQLTERISNMIGVHQVNINIIDGQVTVSYETPANLNSIEKEIYDEGYKIVF

Download         Length: 210 bp

>T38327 NZ_AP024311:c2188653-2188444 [Staphylococcus aureus]
ATGATACATCAAAATACGATTTACACAGCGGGAATTGAAACAGAAGAACAAGTAAGTCAATTGACAGAACGCATTTCAAA
TATGATAGGTGTTCATCAAGTGAATATTAATATAATTGATGGTCAAGTAACGGTATCGTATGAGACACCAGCAAATTTGA
ATAGTATTGAAAAAGAAATTTATGATGAAGGATACAAAATTGTATTTTAG

Antitoxin


Download         Length: 98 a.a.        Molecular weight: 11197.82 Da        Isoelectric Point: 6.2243

>AT38327 WP_000138932.1 NZ_AP024311:c2188958-2188665 [Staphylococcus aureus]
MTEQDNAHHSEQIKTNLKSRLNRIEGQVRAINRMIEEDVYCDDVLTQIRATRSALNSVAIKLLEQHMKSCIMNKVNQGAQ
EEAMEELLVTFQKLIKD

Download         Length: 294 bp

>AT38327 NZ_AP024311:c2188958-2188665 [Staphylococcus aureus]
ATGACTGAACAAGATAATGCACATCATTCTGAACAAATAAAAACGAATCTTAAATCACGTTTAAATCGAATTGAAGGACA
AGTGAGAGCGATTAATCGCATGATTGAAGAAGATGTCTATTGTGATGATGTCCTTACGCAAATAAGAGCGACACGTTCGG
CGTTAAACAGTGTTGCGATAAAGTTATTAGAACAACATATGAAAAGTTGTATTATGAATAAAGTTAATCAAGGAGCTCAG
GAAGAGGCAATGGAAGAGTTATTAGTGACTTTTCAAAAATTGATTAAAGACTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 6FF1

Antitoxin

Source ID Structure
AlphaFold DB W8UW13

References