Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) TsaAT/-
Location 888528..889004 Replicon chromosome
Accession NZ_AP024311
Organism Staphylococcus aureus strain THI2018-120

Toxin (Protein)


Gene name TsaT Uniprot ID T1Y7S2
Locus tag ST1232TP_RS04275 Protein ID WP_000052076.1
Coordinates 888528..888716 (-) Length 63 a.a.

Antitoxin (Protein)


Gene name TsaA Uniprot ID T1Y6P8
Locus tag ST1232TP_RS04280 Protein ID WP_001059690.1
Coordinates 888744..889004 (-) Length 87 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
ST1232TP_RS04245 (884556) 884556..885038 + 483 WP_000824489.1 hypothetical protein -
ST1232TP_RS04250 (885379) 885379..886065 + 687 WP_001574556.1 thermonuclease family protein -
ST1232TP_RS04255 (886422) 886422..886622 + 201 WP_001059082.1 cold-shock protein -
ST1232TP_RS04260 (887119) 887119..887337 - 219 WP_000005881.1 hypothetical protein -
ST1232TP_RS04265 (887398) 887398..887682 - 285 WP_001004403.1 hypothetical protein -
ST1232TP_RS04270 (887770) 887770..888339 - 570 WP_001106655.1 lipoprotein N-acylation protein LnsA -
ST1232TP_RS04275 (888528) 888528..888716 - 189 WP_000052076.1 hypothetical protein Toxin
ST1232TP_RS04280 (888744) 888744..889004 - 261 WP_001059690.1 hypothetical protein Antitoxin
ST1232TP_RS04285 (889346) 889346..889549 + 204 WP_000145163.1 sterile alpha motif-like domain-containing protein -
ST1232TP_RS04290 (889546) 889546..889782 - 237 WP_000368687.1 hypothetical protein -
ST1232TP_RS04295 (890007) 890007..890588 + 582 WP_001140696.1 histidine phosphatase family protein -
ST1232TP_RS04300 (890726) 890726..891898 - 1173 WP_000195429.1 IS256-like element IS256 family transposase -
ST1232TP_RS04305 (891984) 891984..892610 - 627 WP_221046808.1 LysE/ArgO family amino acid transporter -
ST1232TP_RS04310 (892759) 892759..893253 - 495 WP_000569881.1 GNAT family N-acetyltransferase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- flank IS/Tn - - 890726..891898 1172


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

mRNA interferase PemK-like

(10-109)

Antitoxin

SpoVT-AbrB domain

(7-51)


Sequences

Toxin        


Download         Length: 63 a.a.        Molecular weight: 7142.82 Da        Isoelectric Point: 9.9971

>T38320 WP_000052076.1 NZ_AP024311:c888716-888528 [Staphylococcus aureus]
MSLHFAILFWLALIFLVAATFILVLMKKTGKESKKESYLSFTVILYIFGFAILIYTFIFGVL

Download         Length: 189 bp

>T38320 NZ_AP024311:c888716-888528 [Staphylococcus aureus]
ATGTCTTTACATTTTGCAATTCTGTTTTGGCTAGCATTAATTTTCTTAGTTGCCGCTACGTTTATACTCGTATTAATGAA
AAAAACTGGCAAAGAATCTAAAAAAGAGTCCTATTTAAGTTTCACTGTCATTCTCTATATTTTTGGATTCGCTATATTAA
TATACACATTTATATTTGGTGTGCTATAA

Antitoxin


Download         Length: 87 a.a.        Molecular weight: 9940.09 Da        Isoelectric Point: 4.0624

>AT38320 WP_001059690.1 NZ_AP024311:c889004-888744 [Staphylococcus aureus]
MNNILLNAINIVITTTFVIFNILITYNKDLDDLCWLLPGIIICGVILIVSFTIAMITKNWLSEILFFINIVLVLYYIYPI
FYSFIG

Download         Length: 261 bp

>AT38320 NZ_AP024311:c889004-888744 [Staphylococcus aureus]
ATGAATAACATTTTGTTAAATGCTATCAATATAGTTATTACTACCACTTTTGTTATCTTTAATATTTTAATCACATATAA
TAAAGATTTAGATGATTTATGTTGGCTCCTGCCTGGTATTATCATTTGTGGTGTGATACTCATAGTATCCTTTACCATTG
CAATGATAACTAAAAACTGGTTAAGTGAAATATTATTTTTTATAAATATCGTACTCGTTCTCTATTACATTTATCCTATT
TTTTATAGTTTTATAGGTTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0E0VP18

Antitoxin

Source ID Structure
AlphaFold DB A0A0E0VN56

References