Detailed information of TA system TA038312

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): vapBC/VapC(toxin)
• Location: 468517..469169
• Replicon: chromosome
• Accession: NZ_AP024305
• Organism: Thermus thermophilus strain HB5008

Toxin (Protein)

• Gene name: vapC
• Uniprot ID: -
• Locus tag: JQN54_RS02590
• Protein ID: WP_143590560.1
• Coordinates: 468517..468909 (-)
• Length: 131 a.a.

Antitoxin (Protein)

• Gene name: vapB
• Uniprot ID: Q5SKZ1
• Locus tag: JQN54_RS02595
• Protein ID: WP_011227983.1
• Coordinates: 468909..469169 (-)
• Length: 87 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
JQN54_RS02555	463758..464096	-	339	WP_008631771.1	hypothetical protein	-
JQN54_RS02560	464089..465531	-	1443	WP_024118965.1	2-phosphoglycerate kinase	-
JQN54_RS02575	465817..466206	+	390	WP_011227977.1	NADH-quinone oxidoreductase subunit 15	-
JQN54_RS02580	466209..467306	-	1098	WP_203971672.1	radical SAM family heme chaperone HemW	-
JQN54_RS02585	467312..468532	-	1221	WP_201351183.1	glycerate kinase	-
JQN54_RS02590	468517..468909	-	393	WP_143590560.1	type II toxin-antitoxin system VapC family toxin	Toxin
JQN54_RS02595	468909..469169	-	261	WP_011227983.1	type II toxin-antitoxin system VapB family antitoxin	Antitoxin
JQN54_RS02600	469202..470458	-	1257	WP_201351184.1	glycolate oxidase subunit GlcF	-
JQN54_RS02605	470463..471506	-	1044	WP_024118968.1	FAD-binding protein	-
JQN54_RS02610	471493..472875	-	1383	WP_203971673.1	FAD-binding protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• PIN domain (1-124)

Antitoxin

• Antitoxin VapB-like (1-85)

Sequences

Toxin

Protein

• Length: 131 a.a.
• Molecular weight: 14694.85 Da
• Isoelectric Point: 6.4876

>T38312 WP_143590560.1 NZ_AP024305:c468909-468517 [Thermus thermophilus]
MVLDTSALLGILFREEGYEELLEQLRRTRPHKVAAPTLAEAGIVLGARLGFERVHLLFELLTELQAEIVPFTERHAREAI
SAYRRYGRGKHPAGLNFGDCLSYALARVEGEPLLYKGQDFDRTDLAWKPS

Nucleotide

• Length: 393 bp

>T38312 NZ_AP024305:c468909-468517 [Thermus thermophilus]
ATGGTGCTGGACACCTCCGCCCTCCTGGGCATTCTCTTCCGGGAAGAAGGGTACGAGGAGCTTCTGGAGCAACTCCGGCG
CACCCGCCCCCACAAGGTGGCCGCGCCCACCCTGGCCGAAGCGGGGATCGTCCTGGGCGCCCGGCTGGGCTTTGAGCGGG
TGCATCTTCTCTTTGAACTCCTAACCGAGCTCCAGGCCGAGATCGTGCCCTTCACCGAAAGGCATGCCCGGGAGGCCATC
TCCGCTTACCGGCGCTACGGGCGGGGCAAGCACCCCGCCGGGCTCAACTTTGGGGACTGCCTGAGCTACGCCCTGGCCCG
GGTGGAGGGGGAACCCCTCCTCTACAAGGGCCAGGACTTTGACCGGACGGACCTGGCGTGGAAGCCCTCCTGA

Antitoxin

Protein

• Length: 87 a.a.
• Molecular weight: 10086.61 Da
• Isoelectric Point: 5.0285

>AT38312 WP_011227983.1 NZ_AP024305:c469169-468909 [Thermus thermophilus]
MALTIRNKEVERLAEEVARLAGETKTEAVRKALEMRLRELQRKRSFDRVIRFLEEEVWPQIPPELLGKGLSKEEEEEILG
YGKEGY

Nucleotide

• Length: 261 bp

>AT38312 NZ_AP024305:c469169-468909 [Thermus thermophilus]
ATGGCCCTCACCATCCGCAACAAGGAGGTGGAGCGCCTGGCGGAGGAGGTGGCCCGCCTCGCCGGAGAAACCAAGACGGA
GGCCGTAAGGAAGGCCCTGGAGATGCGCCTTAGGGAACTCCAGAGGAAGCGGAGCTTTGACCGGGTGATCCGCTTCCTGG
AAGAGGAAGTCTGGCCCCAAATCCCGCCGGAGCTTTTGGGGAAGGGGCTCTCCAAGGAAGAGGAGGAAGAAATCCTGGGG
TACGGCAAGGAGGGGTACTGA

Structures

Antitoxin

• AlphaFold DB: A0A7R7YHV5