Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/LOTUS_5_Limkain_b1-Phd
Location 962978..963699 Replicon chromosome
Accession NZ_AP024301
Organism Thermus thermophilus strain HB5002

Toxin (Protein)


Gene name vapB Uniprot ID -
Locus tag JQN53_RS05185 Protein ID WP_014511247.1
Coordinates 962978..963394 (-) Length 139 a.a.

Antitoxin (Protein)


Gene name vapC Uniprot ID -
Locus tag JQN53_RS05190 Protein ID WP_014630570.1
Coordinates 963391..963699 (-) Length 103 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
JQN53_RS05160 958152..958940 + 789 WP_203972094.1 tryptophan-rich sensory protein -
JQN53_RS05165 958937..959884 + 948 WP_203972096.1 DUF523 and DUF1722 domain-containing protein -
JQN53_RS05170 959915..960307 - 393 WP_011174492.1 nucleotidyltransferase domain-containing protein -
JQN53_RS05175 960317..961315 - 999 WP_203972098.1 type 2 isopentenyl-diphosphate Delta-isomerase -
JQN53_RS05180 961312..962880 - 1569 WP_203972100.1 phytoene desaturase -
JQN53_RS05185 962978..963394 - 417 WP_014511247.1 type II toxin-antitoxin system VapC family toxin Toxin
JQN53_RS05190 963391..963699 - 309 WP_014630570.1 type II toxin-antitoxin system Phd/YefM family antitoxin Antitoxin
JQN53_RS05195 963705..964727 - 1023 WP_203972102.1 glycosyltransferase -
JQN53_RS05200 964724..965401 - 678 WP_011174498.1 1-acyl-sn-glycerol-3-phosphate acyltransferase -
JQN53_RS05205 965406..966104 - 699 WP_011174499.1 lycopene cyclase domain-containing protein -
JQN53_RS05210 966101..967270 - 1170 WP_143591963.1 cytochrome P450 -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(3-129)

Antitoxin

Type II toxin-antitoxin system, antitoxin Phd/YefM

(20-83)


Sequences

Toxin        


Download         Length: 139 a.a.        Molecular weight: 15241.82 Da        Isoelectric Point: 10.4393

>T38310 WP_014511247.1 NZ_AP024301:c963394-962978 [Thermus thermophilus]
MRYLLDTNVVSEAVKRRPHPKVVAFLRHLKVGEAYLSALTLGELVQGVARAPEARRAILSRWLSGLKASFSGRILPLDAE
VMELWGELTGNAMREGKPLSPLDAMLAATALRHGLILATRNTEDFRHVPVPLVNPWEG

Download         Length: 417 bp

>T38310 NZ_AP024301:c963394-962978 [Thermus thermophilus]
CTGAGGTACCTGCTGGACACCAACGTGGTCTCCGAGGCCGTCAAGCGGCGGCCTCACCCCAAGGTGGTGGCCTTCCTGCG
CCACCTTAAAGTGGGGGAGGCGTACCTCTCCGCCCTCACCTTGGGCGAACTGGTCCAGGGGGTGGCCCGGGCCCCGGAGG
CCCGAAGGGCCATCCTCAGCCGATGGCTCTCGGGGCTGAAGGCGAGCTTCTCGGGGCGGATCCTTCCCCTGGACGCCGAG
GTGATGGAGCTCTGGGGCGAGCTCACCGGAAACGCCATGAGGGAGGGCAAGCCCCTCTCTCCCCTAGACGCCATGCTGGC
GGCCACGGCCCTGCGGCACGGCCTCATCCTGGCCACCCGGAACACCGAGGACTTCCGCCACGTTCCCGTGCCCCTCGTGA
ACCCCTGGGAAGGGTAA

Antitoxin


Download         Length: 103 a.a.        Molecular weight: 11640.40 Da        Isoelectric Point: 8.5043

>AT38310 WP_014630570.1 NZ_AP024301:c963699-963391 [Thermus thermophilus]
VASKLDRPVFSVYPEGVKAIWQLQEAKARFSEVVERALKGEPQLVLRRGKKAVVVLDWETYARLTGEEASVLEALRPPKT
LPNEEVEALFQRQKTGFREVDF

Download         Length: 309 bp

>AT38310 NZ_AP024301:c963699-963391 [Thermus thermophilus]
GTGGCCTCTAAACTAGACAGACCGGTCTTTTCCGTGTACCCTGAGGGGGTGAAGGCCATCTGGCAACTCCAAGAGGCCAA
AGCCCGCTTTTCCGAGGTGGTGGAGCGGGCCCTCAAGGGGGAGCCCCAGCTCGTCCTCCGGCGGGGTAAGAAGGCGGTGG
TGGTGCTGGACTGGGAGACCTACGCCCGGCTCACGGGGGAAGAGGCCTCGGTCCTCGAGGCCCTAAGACCCCCCAAGACC
CTCCCCAATGAGGAGGTGGAAGCCCTCTTCCAAAGGCAAAAGACGGGCTTCCGGGAGGTGGACTTCTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References