Detailed information of TA system TA038309

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): vapBC/VapC(toxin)
• Location: 468518..469170
• Replicon: chromosome
• Accession: NZ_AP024301
• Organism: Thermus thermophilus strain HB5002

Toxin (Protein)

• Gene name: vapC
• Uniprot ID: -
• Locus tag: JQN53_RS02590
• Protein ID: WP_143590560.1
• Coordinates: 468518..468910 (-)
• Length: 131 a.a.

Antitoxin (Protein)

• Gene name: vapB
• Uniprot ID: Q5SKZ1
• Locus tag: JQN53_RS02595
• Protein ID: WP_011227983.1
• Coordinates: 468910..469170 (-)
• Length: 87 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
JQN53_RS02555	463759..464097	-	339	WP_008631771.1	hypothetical protein	-
JQN53_RS02560	464090..465532	-	1443	WP_024118965.1	2-phosphoglycerate kinase	-
JQN53_RS02575	465818..466207	+	390	WP_011227977.1	NADH-quinone oxidoreductase subunit 15	-
JQN53_RS02580	466210..467307	-	1098	WP_203971672.1	radical SAM family heme chaperone HemW	-
JQN53_RS02585	467313..468533	-	1221	WP_201351183.1	glycerate kinase	-
JQN53_RS02590	468518..468910	-	393	WP_143590560.1	type II toxin-antitoxin system VapC family toxin	Toxin
JQN53_RS02595	468910..469170	-	261	WP_011227983.1	type II toxin-antitoxin system VapB family antitoxin	Antitoxin
JQN53_RS02600	469203..470459	-	1257	WP_201351184.1	glycolate oxidase subunit GlcF	-
JQN53_RS02605	470464..471507	-	1044	WP_024118968.1	FAD-binding protein	-
JQN53_RS02610	471494..472876	-	1383	WP_203971673.1	FAD-binding protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• PIN domain (1-124)

Antitoxin

• Antitoxin VapB-like (1-85)

Sequences

Toxin

Protein

• Length: 131 a.a.
• Molecular weight: 14694.85 Da
• Isoelectric Point: 6.4876

>T38309 WP_143590560.1 NZ_AP024301:c468910-468518 [Thermus thermophilus]
MVLDTSALLGILFREEGYEELLEQLRRTRPHKVAAPTLAEAGIVLGARLGFERVHLLFELLTELQAEIVPFTERHAREAI
SAYRRYGRGKHPAGLNFGDCLSYALARVEGEPLLYKGQDFDRTDLAWKPS

Nucleotide

• Length: 393 bp

>T38309 NZ_AP024301:c468910-468518 [Thermus thermophilus]
ATGGTGCTGGACACCTCCGCCCTCCTGGGCATTCTCTTCCGGGAAGAAGGGTACGAGGAGCTTCTGGAGCAACTCCGGCG
CACCCGCCCCCACAAGGTGGCCGCGCCCACCCTGGCCGAAGCGGGGATCGTCCTGGGCGCCCGGCTGGGCTTTGAGCGGG
TGCATCTTCTCTTTGAACTCCTAACCGAGCTCCAGGCCGAGATCGTGCCCTTCACCGAAAGGCATGCCCGGGAGGCCATC
TCCGCTTACCGGCGCTACGGGCGGGGCAAGCACCCCGCCGGGCTCAACTTTGGGGACTGCCTGAGCTACGCCCTGGCCCG
GGTGGAGGGGGAACCCCTCCTCTACAAGGGCCAGGACTTTGACCGGACGGACCTGGCGTGGAAGCCCTCCTGA

Antitoxin

Protein

• Length: 87 a.a.
• Molecular weight: 10086.61 Da
• Isoelectric Point: 5.0285

>AT38309 WP_011227983.1 NZ_AP024301:c469170-468910 [Thermus thermophilus]
MALTIRNKEVERLAEEVARLAGETKTEAVRKALEMRLRELQRKRSFDRVIRFLEEEVWPQIPPELLGKGLSKEEEEEILG
YGKEGY

Nucleotide

• Length: 261 bp

>AT38309 NZ_AP024301:c469170-468910 [Thermus thermophilus]
ATGGCCCTCACCATCCGCAACAAGGAGGTGGAGCGCCTGGCGGAGGAGGTGGCCCGCCTCGCCGGAGAAACCAAGACGGA
GGCCGTAAGGAAGGCCCTGGAGATGCGCCTTAGGGAACTCCAGAGGAAGCGGAGCTTTGACCGGGTGATCCGCTTCCTGG
AAGAGGAAGTCTGGCCCCAAATCCCGCCGGAGCTTTTGGGGAAGGGGCTCTCCAAGGAAGAGGAGGAAGAAATCCTGGGG
TACGGCAAGGAGGGGTACTGA

Structures

Antitoxin

• AlphaFold DB: A0A7R7YHV5