Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) tacAT/ElaA-DUF1778
Location 37588..38327 Replicon plasmid pEnt261
Accession NZ_AP024282
Organism Enterobacter asburiae strain Ent261

Toxin (Protein)


Gene name tacT Uniprot ID A0A9E6WPH7
Locus tag R1N_RS24120 Protein ID WP_013087269.1
Coordinates 37588..38073 (-) Length 162 a.a.

Antitoxin (Protein)


Gene name tacA Uniprot ID A0A9E6WPN8
Locus tag R1N_RS24125 Protein ID WP_007869691.1
Coordinates 38061..38327 (-) Length 89 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
R1N_RS24095 (33829) 33829..34534 + 706 Protein_33 IS6-like element IS26 family transposase -
R1N_RS24100 (34574) 34574..34876 + 303 WP_223998212.1 helix-turn-helix transcriptional regulator -
R1N_RS24105 (34881) 34881..36150 + 1270 Protein_35 type II toxin-antitoxin system HipA family toxin -
R1N_RS24110 (36353) 36353..36763 + 411 WP_023327703.1 hypothetical protein -
R1N_RS24115 (36776) 36776..37387 + 612 WP_223998213.1 hypothetical protein -
R1N_RS24120 (37588) 37588..38073 - 486 WP_013087269.1 GNAT family N-acetyltransferase Toxin
R1N_RS24125 (38061) 38061..38327 - 267 WP_007869691.1 DUF1778 domain-containing protein Antitoxin
R1N_RS24130 (38995) 38995..39993 + 999 WP_049015826.1 plasmid replication initiator RepA -
R1N_RS24135 (40944) 40944..41750 + 807 WP_023327700.1 DUF4225 domain-containing protein -
R1N_RS24140 (41725) 41725..42051 - 327 WP_023327699.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Non-Mobilizable plasmid - - 1..139475 139475


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

GNAT domain

(45-146)

Antitoxin

Vibrio phage ICP1, Orf50

(6-82)


Sequences

Toxin        


Download         Length: 162 a.a.        Molecular weight: 17736.45 Da        Isoelectric Point: 9.5181

>T38308 WP_013087269.1 NZ_AP024282:c38073-37588 [Enterobacter asburiae]
VGRVTAPEPLSSSHQLAEFVSGEAVLDDWLKQRGLKNQALGAARTFVVCKRDTKQVVGFYSLATGSVNHVEAMGSLRRNM
PDPIPVIILARLAVDVSYRGQGLGADLLHDAVLRCYRVAENIGVRAIMVHALTEEAKNFYLHHGFKASQTQERTLFLKLP
Q

Download         Length: 486 bp

>T38308 NZ_AP024282:c38073-37588 [Enterobacter asburiae]
GTGGGACGTGTAACAGCACCAGAACCATTATCCAGCTCCCATCAACTAGCAGAGTTCGTCAGTGGTGAGGCAGTACTTGA
TGACTGGCTTAAACAGAGGGGATTAAAAAACCAAGCTCTTGGTGCAGCACGAACGTTCGTCGTTTGTAAAAGAGACACTA
AACAGGTTGTCGGTTTTTACTCTCTGGCCACCGGCAGCGTTAACCACGTGGAAGCAATGGGAAGCCTCAGGCGCAATATG
CCAGATCCAATTCCCGTAATCATACTTGCTCGCCTGGCAGTTGATGTTTCATACCGTGGCCAAGGGCTCGGGGCCGATTT
ACTGCATGATGCAGTTCTGCGCTGTTACCGTGTAGCTGAGAATATTGGAGTCCGTGCGATTATGGTTCATGCACTGACTG
AAGAAGCCAAAAACTTTTATCTTCACCATGGCTTTAAGGCATCACAAACTCAGGAACGGACATTGTTTTTAAAGTTACCA
CAGTGA

Antitoxin


Download         Length: 89 a.a.        Molecular weight: 10080.46 Da        Isoelectric Point: 4.3837

>AT38308 WP_007869691.1 NZ_AP024282:c38327-38061 [Enterobacter asburiae]
MKSDVQLNLRAKESQRALIDAAAEILHKSRTDFILEMACQAAENVILDRRVFNFNDEQYAEFIDMLDAPVSDEAAIDKLL
ARKPQWDV

Download         Length: 267 bp

>AT38308 NZ_AP024282:c38327-38061 [Enterobacter asburiae]
ATGAAATCAGATGTTCAGCTCAACCTTAGAGCTAAAGAATCTCAAAGAGCACTTATTGATGCTGCAGCAGAGATTCTCCA
TAAATCACGCACGGACTTCATCCTGGAAATGGCATGTCAGGCTGCGGAGAATGTGATCCTCGATCGTCGCGTATTTAATT
TTAACGATGAGCAGTATGCAGAGTTTATCGATATGCTCGATGCACCGGTTTCGGATGAGGCGGCTATTGATAAACTTCTG
GCAAGGAAACCTCAGTGGGACGTGTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References