Detailed information of TA system TA038288

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): hicAB/HicA-HicB
• Location: 1486052..1486721
• Replicon: chromosome
• Accession: NZ_AP024276
• Organism: Streptococcus parasuis strain SUT-286

Toxin (Protein)

• Gene name: hicA
• Uniprot ID: G7SGM1
• Locus tag: L6410_RS07425
• Protein ID: WP_014637653.1
• Coordinates: 1486539..1486721 (-)
• Length: 61 a.a.

Antitoxin (Protein)

• Gene name: hicB
• Uniprot ID: -
• Locus tag: L6410_RS07420
• Protein ID: WP_160863757.1
• Coordinates: 1486052..1486501 (-)
• Length: 150 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
L6410_RS07405 (SUT286_14360)	1481282..1483744	-	2463	WP_237395243.1	heavy metal translocating P-type ATPase	-
L6410_RS07410 (SUT286_14370)	1483839..1484696	-	858	WP_237395244.1	SAM-dependent methyltransferase TehB	-
L6410_RS07415 (SUT286_14380)	1484850..1485893	+	1044	WP_172090247.1	alcohol dehydrogenase catalytic domain-containing protein	-
L6410_RS07420 (SUT286_14390)	1486052..1486501	-	450	WP_160863757.1	type II toxin-antitoxin system HicB family antitoxin	Antitoxin
L6410_RS07425 (SUT286_14400)	1486539..1486721	-	183	WP_014637653.1	type II toxin-antitoxin system HicA family toxin	Toxin
L6410_RS07430 (SUT286_14410)	1487097..1487564	-	468	WP_237395245.1	SsrA-binding protein SmpB	-
L6410_RS07435 (SUT286_14420)	1487567..1489936	-	2370	WP_237395246.1	ribonuclease R	-
L6410_RS07440 (SUT286_14430)	1489986..1490219	-	234	WP_024396799.1	preprotein translocase subunit SecG	-
L6410_RS07445	1490266..1490415	-	150	WP_012775228.1	50S ribosomal protein L33	-
L6410_RS07450 (SUT286_14440)	1490415..1491620	-	1206	WP_237395247.1	multidrug efflux MFS transporter	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• HicA mRNA interferase family (6-59)

Antitoxin

• HicB-like antitoxin of toxin-antitoxin system (17-113)

Sequences

Toxin

Protein

• Length: 61 a.a.
• Molecular weight: 6653.87 Da
• Isoelectric Point: 10.8207

>T38288 WP_014637653.1 NZ_AP024276:c1486721-1486539 [Streptococcus parasuis]
MPMTQKEMVKLLTAHGWTKTKGGKGSHVKLEKAGERPITIPHGEINKYTERGIKKQAGLL

Nucleotide

• Length: 183 bp

>T38288 NZ_AP024276:c1486721-1486539 [Streptococcus parasuis]
ATGCCTATGACACAAAAAGAAATGGTTAAGCTACTTACCGCCCATGGTTGGACAAAAACCAAAGGCGGTAAGGGGTCACA
CGTGAAACTTGAAAAAGCAGGCGAGCGACCCATAACCATTCCCCACGGTGAAATAAACAAATATACCGAAAGGGGTATCA
AAAAGCAAGCAGGGCTGTTATAA

Antitoxin

Protein

• Length: 150 a.a.
• Molecular weight: 16639.64 Da
• Isoelectric Point: 3.9790

>AT38288 WP_160863757.1 NZ_AP024276:c1486501-1486052 [Streptococcus parasuis]
MLVTYPALFYFDDTDGANAPYFVTFPDFEHSATQGEDMADAMAMASDWLGMNLADYIENGRDIPTPSSINTLSLVDNNPF
RDEDFEMVYDSSKSFISMVMVDVAKYLGSQEPVKKTLTIPRWADTLGRELGLNFSQTLTDAIADKKIHA

Nucleotide

• Length: 450 bp

>AT38288 NZ_AP024276:c1486501-1486052 [Streptococcus parasuis]
ATGCTTGTCACTTATCCAGCTTTATTTTATTTTGATGATACAGACGGAGCTAACGCACCCTACTTTGTAACATTCCCTGA
TTTTGAGCATTCAGCAACTCAAGGCGAGGATATGGCGGACGCTATGGCAATGGCTAGCGATTGGTTAGGCATGAACTTAG
CTGATTATATCGAGAATGGACGAGACATTCCTACCCCGTCTTCTATAAATACTTTGTCATTAGTAGATAATAACCCTTTC
CGTGATGAGGATTTTGAGATGGTTTACGATTCTAGCAAGTCTTTTATCTCCATGGTGATGGTGGATGTTGCAAAGTATTT
GGGCAGTCAAGAGCCAGTAAAGAAAACACTCACTATCCCACGCTGGGCAGACACACTAGGACGTGAACTAGGATTGAATT
TCTCACAGACCCTCACAGATGCAATTGCAGATAAAAAAATTCATGCTTAA

Structures

Toxin

• AlphaFold DB: G7SGM1