Detailed information of TA system TA038286

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): relE-parD/RelE-RelB
• Location: 1444093..1444796
• Replicon: chromosome
• Accession: NZ_AP024276
• Organism: Streptococcus parasuis strain SUT-286

Toxin (Protein)

• Gene name: relE
• Uniprot ID: -
• Locus tag: L6410_RS07220
• Protein ID: WP_130554938.1
• Coordinates: 1444527..1444796 (-)
• Length: 90 a.a.

Antitoxin (Protein)

• Gene name: parD
• Uniprot ID: -
• Locus tag: L6410_RS07215
• Protein ID: WP_024391983.1
• Coordinates: 1444093..1444380 (-)
• Length: 96 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
L6410_RS07190 (SUT286_13900)	1439806..1440780	-	975	WP_105127521.1	YvcK family protein	-
L6410_RS07195 (SUT286_13910)	1440777..1441664	-	888	WP_237395216.1	RNase adapter RapZ	-
L6410_RS07200 (SUT286_13920)	1441685..1442065	-	381	WP_160863787.1	RidA family protein	-
L6410_RS07205 (SUT286_13930)	1442116..1443435	-	1320	WP_237395217.1	MATE family efflux transporter	-
L6410_RS07210 (SUT286_13950)	1443755..1444093	-	339	WP_172075293.1	type II toxin-antitoxin system RelE/ParE family toxin	-
L6410_RS07215 (SUT286_13960)	1444093..1444380	-	288	WP_024391983.1	type II toxin-antitoxin system RelB/DinJ family antitoxin	Antitoxin
L6410_RS07220 (SUT286_13970)	1444527..1444796	-	270	WP_130554938.1	type II toxin-antitoxin system RelE/ParE family toxin	Toxin
L6410_RS07225 (SUT286_13980)	1444786..1445013	-	228	WP_160863847.1	DUF6290 family protein	-
L6410_RS07230 (SUT286_13990)	1445127..1446473	-	1347	WP_024391985.1	asparagine--tRNA ligase	-
L6410_RS07235 (SUT286_14000)	1446489..1447670	-	1182	WP_172040148.1	pyridoxal phosphate-dependent aminotransferase	-
L6410_RS07240 (SUT286_14010)	1447667..1448164	-	498	WP_237395218.1	DUF5590 domain-containing protein	-
L6410_RS07245 (SUT286_14020)	1448311..1448751	+	441	WP_160863781.1	MarR family winged helix-turn-helix transcriptional regulator	-
L6410_RS07250 (SUT286_14030)	1448829..1449374	+	546	WP_160863780.1	NADPH-dependent FMN reductase	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin-antitoxin system, RelE/ParE toxin family (6-87)

Antitoxin

• RelB antitoxin/Antitoxin DinJ (10-76)

Sequences

Toxin

Protein

• Length: 90 a.a.
• Molecular weight: 10451.48 Da
• Isoelectric Point: 10.4241

>T38286 WP_130554938.1 NZ_AP024276:c1444796-1444527 [Streptococcus parasuis]
MAYKLVLSDDALKQLKKMDRHVGMMLAKDLKKRLDGLENPRQFGKALVGDYKGLWRYRVGNYRVICDIIDNKMVILALEI
GHRKDIYRK

Nucleotide

• Length: 270 bp

>T38286 NZ_AP024276:c1444796-1444527 [Streptococcus parasuis]
ATGGCTTATAAACTTGTTCTCAGCGATGATGCTTTGAAGCAGTTGAAAAAAATGGACCGGCATGTAGGGATGATGCTTGC
TAAGGATTTGAAAAAAAGATTGGACGGTTTGGAAAATCCAAGACAGTTTGGTAAGGCCTTGGTAGGAGACTATAAGGGCC
TGTGGCGGTATAGAGTGGGGAATTACCGTGTGATTTGCGATATTATTGATAACAAAATGGTCATCTTAGCTCTTGAAATC
GGGCATCGGAAAGATATTTATCGAAAATGA

Antitoxin

Protein

• Length: 96 a.a.
• Molecular weight: 10841.33 Da
• Isoelectric Point: 4.6360

>AT38286 WP_024391983.1 NZ_AP024276:c1444380-1444093 [Streptococcus parasuis]
MPTVIRDKQINFKVNSEYFELAKEVFQENGLDITSAFNEFVQEVAISKTLPFKTVEEKEREKLIARLQEEVSTSYEELKA
GKGLSVEEARKAVLG

Nucleotide

• Length: 288 bp

>AT38286 NZ_AP024276:c1444380-1444093 [Streptococcus parasuis]
ATGCCAACAGTAATAAGGGATAAACAAATCAACTTCAAAGTAAACTCAGAATACTTTGAATTAGCGAAAGAGGTCTTTCA
GGAAAACGGACTGGATATTACATCAGCATTCAATGAATTTGTCCAAGAGGTCGCAATTTCCAAAACATTACCTTTTAAGA
CAGTAGAGGAAAAAGAGAGAGAGAAGTTAATTGCTCGACTTCAAGAAGAAGTTTCCACTAGCTATGAAGAGCTAAAAGCA
GGTAAGGGGTTGTCGGTTGAGGAAGCAAGAAAGGCAGTACTAGGATAA