Detailed information of TA system TA038283

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): relBE/RelE(toxin)
• Location: 1045121..1045613
• Replicon: chromosome
• Accession: NZ_AP024276
• Organism: Streptococcus parasuis strain SUT-286

Toxin (Protein)

• Gene name: relE
• Uniprot ID: -
• Locus tag: L6410_RS05215
• Protein ID: WP_024397534.1
• Coordinates: 1045121..1045378 (-)
• Length: 86 a.a.

Antitoxin (Protein)

• Gene name: relB
• Uniprot ID: A0A0Z8GIU7
• Locus tag: L6410_RS05220
• Protein ID: WP_024385224.1
• Coordinates: 1045362..1045613 (-)
• Length: 84 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
L6410_RS05195 (SUT286_09880)	1040650..1041720	+	1071	WP_237396716.1	tyrosine recombinase XerS	-
L6410_RS05200 (SUT286_09890)	1041790..1043298	-	1509	WP_237396513.1	phosphomannomutase/phosphoglucomutase	-
L6410_RS05205 (SUT286_09900)	1043475..1044416	-	942	WP_237396515.1	sensor histidine kinase	-
L6410_RS05210 (SUT286_09910)	1044413..1045081	-	669	WP_024381849.1	response regulator transcription factor	-
L6410_RS05215 (SUT286_09920)	1045121..1045378	-	258	WP_024397534.1	type II toxin-antitoxin system RelE/ParE family toxin	Toxin
L6410_RS05220 (SUT286_09930)	1045362..1045613	-	252	WP_024385224.1	DUF6290 family protein	Antitoxin
L6410_RS05225 (SUT286_09940)	1045704..1047674	-	1971	WP_237396518.1	ABC transporter permease	-
L6410_RS05230 (SUT286_09950)	1047675..1048427	-	753	WP_024407069.1	ABC transporter ATP-binding protein	-
L6410_RS05235 (SUT286_09960)	1048436..1048825	-	390	WP_105139035.1	NisI/SpaI family lantibiotic immunity lipoprotein	-
L6410_RS05240 (SUT286_09970)	1048838..1048978	-	141	WP_237396520.1	hypothetical protein	-
L6410_RS05245 (SUT286_09980)	1049119..1050285	-	1167	WP_237396535.1	ATP-grasp domain-containing protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin-antitoxin system, RelE/ParE toxin family (10-75)

Antitoxin

• Protein of unknown function DUF6290 (1-75)

Sequences

Toxin

Protein

• Length: 86 a.a.
• Molecular weight: 9968.63 Da
• Isoelectric Point: 10.8924

>T38283 WP_024397534.1 NZ_AP024276:c1045378-1045121 [Streptococcus parasuis]
MKTCYKLVPTSRFIKQLKKLDKFTQKQITNYLSSHVTDNPRQYGKALTANRSGQWRYRIGNYRVIVSIEDDKLILTSLKM
RNGSI

Nucleotide

• Length: 258 bp

>T38283 NZ_AP024276:c1045378-1045121 [Streptococcus parasuis]
ATGAAGACTTGTTATAAACTCGTACCAACCAGTCGTTTTATCAAACAGTTGAAAAAGCTGGATAAATTTACTCAAAAGCA
GATTACCAACTACCTGTCCAGTCATGTGACTGACAACCCCAGGCAATACGGAAAAGCCTTAACTGCCAATCGTTCTGGCC
AATGGCGCTACCGTATCGGCAATTACAGGGTTATCGTCAGCATTGAAGATGACAAATTGATTTTGACAAGTCTAAAAATG
AGAAATGGAAGTATATAA

Antitoxin

Protein

• Length: 84 a.a.
• Molecular weight: 9424.64 Da
• Isoelectric Point: 3.7128

>AT38283 WP_024385224.1 NZ_AP024276:c1045613-1045362 [Streptococcus parasuis]
MAAITLKVSEQDKLFMQAMAKFEGVSLSELIRTKTLEALEDEYDARVADIAWAEYQEDLANGIEPISWEEMLEELGLTNE
DLL

Nucleotide

• Length: 252 bp

>AT38283 NZ_AP024276:c1045613-1045362 [Streptococcus parasuis]
ATGGCAGCTATTACATTGAAAGTTTCTGAGCAGGACAAGCTCTTTATGCAGGCTATGGCAAAGTTTGAAGGTGTCAGTTT
GTCAGAACTCATTCGGACTAAAACCCTTGAAGCTCTTGAGGACGAATACGATGCCCGCGTGGCAGACATAGCCTGGGCAG
AATACCAAGAAGACTTGGCAAACGGCATTGAGCCGATTAGCTGGGAGGAAATGTTGGAAGAGTTGGGATTGACGAATGAA
GACTTGTTATAA

Structures

Antitoxin

• AlphaFold DB: A0A0Z8GIU7