Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relBE/RelE(toxin)
Location 253661..254144 Replicon chromosome
Accession NZ_AP024276
Organism Streptococcus parasuis strain SUT-286

Toxin (Protein)


Gene name relE Uniprot ID A0A4P7WQV5
Locus tag L6410_RS01275 Protein ID WP_024391431.1
Coordinates 253884..254144 (+) Length 87 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID A0A4T2HAA1
Locus tag L6410_RS01270 Protein ID WP_024391430.1
Coordinates 253661..253882 (+) Length 74 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
L6410_RS01250 (SUT286_02300) 249390..250442 + 1053 WP_024391426.1 3-isopropylmalate dehydrogenase -
L6410_RS01255 (SUT286_02310) 250439..251830 + 1392 WP_024391427.1 3-isopropylmalate dehydratase large subunit -
L6410_RS01260 (SUT286_02320) 251830..252423 + 594 WP_024391428.1 3-isopropylmalate dehydratase small subunit -
L6410_RS01265 (SUT286_02330) 252764..253549 + 786 WP_024391429.1 Sua5/YciO/YrdC/YwlC family protein -
L6410_RS01270 (SUT286_02340) 253661..253882 + 222 WP_024391430.1 DUF6290 family protein Antitoxin
L6410_RS01275 (SUT286_02350) 253884..254144 + 261 WP_024391431.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
L6410_RS01280 (SUT286_02360) 254217..255077 - 861 WP_237395650.1 helix-turn-helix transcriptional regulator -
L6410_RS01285 (SUT286_02370) 255208..255420 + 213 WP_024391433.1 hypothetical protein -
L6410_RS01290 (SUT286_02380) 255490..256374 + 885 WP_024391434.1 ATP-binding cassette domain-containing protein -
L6410_RS01295 (SUT286_02390) 256371..258713 + 2343 WP_024391435.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(4-86)

Antitoxin

Protein of unknown function DUF6290

(1-71)


Sequences

Toxin        


Download         Length: 87 a.a.        Molecular weight: 10350.93 Da        Isoelectric Point: 9.8183

>T38282 WP_024391431.1 NZ_AP024276:253884-254144 [Streptococcus parasuis]
MFHVEYSKKAQKQIRKLDKQIQRLLFAWVDKHLDGTVNPRLHGKGLTGDHANEWRYRIGDYRLICDIQDDRMVILALEFG
HRRDIY

Download         Length: 261 bp

>T38282 NZ_AP024276:253884-254144 [Streptococcus parasuis]
ATGTTTCATGTAGAGTATTCTAAGAAGGCGCAGAAACAAATCAGAAAATTGGATAAGCAAATCCAAAGATTATTATTTGC
ATGGGTGGATAAACACTTAGACGGTACAGTTAATCCGAGGTTGCATGGCAAGGGATTGACAGGGGACCATGCCAATGAGT
GGCGTTATCGTATCGGTGATTATCGGCTGATTTGCGATATTCAGGATGATAGGATGGTTATTCTGGCACTTGAATTTGGT
CATCGTAGAGATATTTATTAA

Antitoxin


Download         Length: 74 a.a.        Molecular weight: 8596.58 Da        Isoelectric Point: 4.4915

>AT38282 WP_024391430.1 NZ_AP024276:253661-253882 [Streptococcus parasuis]
MSTVTIRLNKEEEVFFKSYAQLTGQSLSSLFKKALERDIEDEYDLSIYHQAYEEYQKDPETISHADFKKELGL

Download         Length: 222 bp

>AT38282 NZ_AP024276:253661-253882 [Streptococcus parasuis]
ATGAGTACAGTAACTATCCGATTAAACAAAGAGGAAGAAGTATTTTTCAAGAGCTATGCTCAATTGACTGGTCAAAGTCT
TTCAAGTTTATTTAAGAAGGCGCTTGAGCGTGATATTGAGGATGAGTATGATTTGAGCATTTACCATCAAGCCTACGAGG
AGTACCAGAAAGATCCTGAAACCATCAGTCATGCTGATTTCAAGAAGGAACTTGGTCTGTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A4P7WQV5

Antitoxin

Source ID Structure
AlphaFold DB A0A4T2HAA1

References