Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/LOTUS_5_Limkain_b1-Phd
Location 46104..46825 Replicon plasmid pHB5018d
Accession NZ_AP024273
Organism Thermus thermophilus strain HB5018

Toxin (Protein)


Gene name vapB Uniprot ID -
Locus tag JMH49_RS12930 Protein ID WP_162467455.1
Coordinates 46104..46520 (-) Length 139 a.a.

Antitoxin (Protein)


Gene name vapC Uniprot ID -
Locus tag JMH49_RS12935 Protein ID WP_014630570.1
Coordinates 46517..46825 (-) Length 103 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
JMH49_RS12905 41278..42066 + 789 WP_201351663.1 tryptophan-rich sensory protein -
JMH49_RS12910 42063..43010 + 948 WP_024119841.1 DUF523 and DUF1722 domain-containing protein -
JMH49_RS12915 43041..43433 - 393 WP_011174492.1 nucleotidyltransferase domain-containing protein -
JMH49_RS12920 43443..44441 - 999 WP_011229187.1 type 2 isopentenyl-diphosphate Delta-isomerase -
JMH49_RS12925 44438..46006 - 1569 WP_143591965.1 phytoene desaturase -
JMH49_RS12930 46104..46520 - 417 WP_162467455.1 type II toxin-antitoxin system VapC family toxin Toxin
JMH49_RS12935 46517..46825 - 309 WP_014630570.1 type II toxin-antitoxin system Phd/YefM family antitoxin Antitoxin
JMH49_RS12940 46831..47859 - 1029 WP_201351664.1 glycosyltransferase -
JMH49_RS12945 47856..48533 - 678 WP_143591964.1 1-acyl-sn-glycerol-3-phosphate acyltransferase -
JMH49_RS12950 48538..49236 - 699 WP_011174499.1 lycopene cyclase domain-containing protein -
JMH49_RS12955 49233..50402 - 1170 WP_201351665.1 cytochrome P450 -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Non-Mobilizable plasmid - - 1..109754 109754


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(3-129)

Antitoxin

Type II toxin-antitoxin system, antitoxin Phd/YefM

(20-83)


Sequences

Toxin        


Download         Length: 139 a.a.        Molecular weight: 15255.85 Da        Isoelectric Point: 10.4393

>T38279 WP_162467455.1 NZ_AP024273:c46520-46104 [Thermus thermophilus]
MRYLLDTNVVSEAVKRRPHPKVVAFLRHLKVGEAYLSALTLGELVQGVARAPEARRAILSRWLSGLKASFSGRILPLDAE
VMELWGELTGNAMREGKPLSPLDAMLAATALRHGLILATRNTEEFRHVPVPLVNPWEG

Download         Length: 417 bp

>T38279 NZ_AP024273:c46520-46104 [Thermus thermophilus]
CTGAGGTACCTGCTGGACACCAACGTGGTCTCCGAGGCCGTCAAGCGGCGGCCTCACCCCAAGGTGGTGGCCTTCCTGCG
CCACCTTAAAGTGGGGGAGGCGTACCTCTCCGCCCTCACCTTGGGCGAACTGGTCCAGGGGGTGGCCCGGGCCCCGGAGG
CCCGAAGGGCCATCCTCAGCCGATGGCTCTCGGGGCTGAAGGCGAGCTTCTCGGGGCGGATCCTTCCCCTGGACGCCGAG
GTGATGGAGCTCTGGGGCGAGCTCACCGGAAACGCCATGAGGGAGGGCAAGCCCCTCTCTCCCCTAGACGCCATGCTGGC
GGCCACGGCCCTGCGGCACGGCCTGATCCTGGCCACCCGGAACACCGAGGAGTTCCGCCACGTTCCCGTGCCCCTCGTGA
ACCCCTGGGAAGGGTAA

Antitoxin


Download         Length: 103 a.a.        Molecular weight: 11640.40 Da        Isoelectric Point: 8.5043

>AT38279 WP_014630570.1 NZ_AP024273:c46825-46517 [Thermus thermophilus]
VASKLDRPVFSVYPEGVKAIWQLQEAKARFSEVVERALKGEPQLVLRRGKKAVVVLDWETYARLTGEEASVLEALRPPKT
LPNEEVEALFQRQKTGFREVDF

Download         Length: 309 bp

>AT38279 NZ_AP024273:c46825-46517 [Thermus thermophilus]
GTGGCCTCTAAACTAGACAGACCGGTCTTTTCCGTGTACCCTGAGGGGGTGAAGGCCATCTGGCAACTCCAAGAGGCCAA
AGCCCGCTTTTCCGAGGTGGTGGAGCGGGCCCTCAAGGGGGAGCCCCAGCTCGTCCTCCGGCGGGGTAAGAAGGCGGTGG
TGGTGCTGGACTGGGAGACCTACGCCCGGCTCACCGGGGAAGAGGCCTCGGTCCTCGAGGCCCTAAGACCCCCCAAGACC
CTCCCCAATGAGGAGGTGGAAGCCCTCTTCCAAAGGCAAAAGACGGGCTTCCGGGAGGTGGACTTCTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References