Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/LOTUS_5_Limkain_b1-Phd
Location 157225..157946 Replicon plasmid pHB5018b
Accession NZ_AP024271
Organism Thermus thermophilus strain HB5018

Toxin (Protein)


Gene name vapB Uniprot ID -
Locus tag JMH49_RS11410 Protein ID WP_162467455.1
Coordinates 157225..157641 (-) Length 139 a.a.

Antitoxin (Protein)


Gene name vapC Uniprot ID -
Locus tag JMH49_RS11415 Protein ID WP_014630570.1
Coordinates 157638..157946 (-) Length 103 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
JMH49_RS11385 152406..153185 + 780 Protein_169 tryptophan-rich sensory protein -
JMH49_RS11390 153222..154135 + 914 Protein_170 DUF523 and DUF1722 domain-containing protein -
JMH49_RS11395 154166..154558 - 393 WP_011174492.1 nucleotidyltransferase domain-containing protein -
JMH49_RS11400 154568..155565 - 998 Protein_172 type 2 isopentenyl-diphosphate Delta-isomerase -
JMH49_RS11405 155562..157127 - 1566 Protein_173 phytoene desaturase -
JMH49_RS11410 157225..157641 - 417 WP_162467455.1 type II toxin-antitoxin system VapC family toxin Toxin
JMH49_RS11415 157638..157946 - 309 WP_014630570.1 type II toxin-antitoxin system Phd/YefM family antitoxin Antitoxin
JMH49_RS11420 157952..158979 - 1028 Protein_176 glycosyltransferase -
JMH49_RS11425 158976..159649 - 674 Protein_177 1-acyl-sn-glycerol-3-phosphate acyltransferase -
JMH49_RS11430 159654..160351 - 698 Protein_178 lycopene cyclase domain-containing protein -
JMH49_RS11435 160348..161516 - 1169 Protein_179 cytochrome P450 -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Non-Mobilizable plasmid - - 1..228111 228111


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(3-129)

Antitoxin

Type II toxin-antitoxin system, antitoxin Phd/YefM

(20-83)


Sequences

Toxin        


Download         Length: 139 a.a.        Molecular weight: 15255.85 Da        Isoelectric Point: 10.4393

>T38277 WP_162467455.1 NZ_AP024271:c157641-157225 [Thermus thermophilus]
MRYLLDTNVVSEAVKRRPHPKVVAFLRHLKVGEAYLSALTLGELVQGVARAPEARRAILSRWLSGLKASFSGRILPLDAE
VMELWGELTGNAMREGKPLSPLDAMLAATALRHGLILATRNTEEFRHVPVPLVNPWEG

Download         Length: 417 bp

>T38277 NZ_AP024271:c157641-157225 [Thermus thermophilus]
CTGAGGTACCTGCTGGACACCAACGTGGTCTCCGAGGCCGTCAAGCGGCGGCCTCACCCCAAGGTGGTGGCCTTCCTGCG
CCACCTTAAAGTGGGGGAGGCGTACCTCTCCGCCCTCACCTTGGGCGAACTGGTCCAGGGGGTGGCCCGGGCCCCGGAGG
CCCGAAGGGCCATCCTCAGCCGATGGCTCTCGGGGCTGAAGGCGAGCTTCTCGGGGCGGATCCTTCCCCTGGACGCCGAG
GTGATGGAGCTCTGGGGCGAGCTCACCGGAAACGCCATGAGGGAGGGCAAGCCCCTCTCTCCCCTAGACGCCATGCTGGC
GGCCACGGCCCTGCGGCACGGCCTGATCCTGGCCACCCGGAACACCGAGGAGTTCCGCCACGTTCCCGTGCCCCTCGTGA
ACCCCTGGGAAGGGTAA

Antitoxin


Download         Length: 103 a.a.        Molecular weight: 11640.40 Da        Isoelectric Point: 8.5043

>AT38277 WP_014630570.1 NZ_AP024271:c157946-157638 [Thermus thermophilus]
VASKLDRPVFSVYPEGVKAIWQLQEAKARFSEVVERALKGEPQLVLRRGKKAVVVLDWETYARLTGEEASVLEALRPPKT
LPNEEVEALFQRQKTGFREVDF

Download         Length: 309 bp

>AT38277 NZ_AP024271:c157946-157638 [Thermus thermophilus]
GTGGCCTCTAAACTAGACAGACCGGTCTTTTCCGTGTACCCTGAGGGGGTGAAGGCCATCTGGCAACTCCAAGAGGCCAA
AGCCCGCTTTTCCGAGGTGGTGGAGCGGGCCCTCAAGGGGGAGCCCCAGCTCGTCCTCCGGCGGGGTAAGAAGGCGGTGG
TGGTGCTGGACTGGGAGACCTACGCCCGGCTCACCGGGGAAGAGGCCTCGGTCCTCGAGGCCCTAAGACCCCCCAAGACC
CTCCCCAATGAGGAGGTGGAAGCCCTCTTCCAAAGGCAAAAGACGGGCTTCCGGGAGGTGGACTTCTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References