Detailed information of TA system TA038276

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): vapBC/VapC(toxin)
• Location: 475454..476106
• Replicon: chromosome
• Accession: NZ_AP024270
• Organism: Thermus thermophilus strain HB5018

Toxin (Protein)

• Gene name: vapC
• Uniprot ID: -
• Locus tag: JMH49_RS02625
• Protein ID: WP_143590560.1
• Coordinates: 475454..475846 (-)
• Length: 131 a.a.

Antitoxin (Protein)

• Gene name: vapB
• Uniprot ID: Q5SKZ1
• Locus tag: JMH49_RS02630
• Protein ID: WP_011227983.1
• Coordinates: 475846..476106 (-)
• Length: 87 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
JMH49_RS02600	472057..472446	+	390	WP_011227977.1	NADH-quinone oxidoreductase subunit 15	-
JMH49_RS02605	472449..473546	-	1098	WP_201351182.1	radical SAM family heme chaperone HemW	-
JMH49_RS02610	473539..473937	-	399	WP_011227979.1	HEPN domain-containing protein	-
JMH49_RS02615	473927..474244	-	318	WP_011227980.1	nucleotidyltransferase domain-containing protein	-
JMH49_RS02620	474249..475469	-	1221	WP_201351183.1	glycerate kinase	-
JMH49_RS02625	475454..475846	-	393	WP_143590560.1	type II toxin-antitoxin system VapC family toxin	Toxin
JMH49_RS02630	475846..476106	-	261	WP_011227983.1	type II toxin-antitoxin system VapB family antitoxin	Antitoxin
JMH49_RS02635	476139..477395	-	1257	WP_201351184.1	glycolate oxidase subunit GlcF	-
JMH49_RS02640	477400..478443	-	1044	WP_201351185.1	FAD-binding protein	-
JMH49_RS02645	478430..479812	-	1383	WP_011227986.1	FAD-binding protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• PIN domain (1-124)

Antitoxin

• Antitoxin VapB-like (1-85)

Sequences

Toxin

Protein

• Length: 131 a.a.
• Molecular weight: 14694.85 Da
• Isoelectric Point: 6.4876

>T38276 WP_143590560.1 NZ_AP024270:c475846-475454 [Thermus thermophilus]
MVLDTSALLGILFREEGYEELLEQLRRTRPHKVAAPTLAEAGIVLGARLGFERVHLLFELLTELQAEIVPFTERHAREAI
SAYRRYGRGKHPAGLNFGDCLSYALARVEGEPLLYKGQDFDRTDLAWKPS

Nucleotide

• Length: 393 bp

>T38276 NZ_AP024270:c475846-475454 [Thermus thermophilus]
ATGGTGCTGGACACCTCCGCCCTCCTGGGCATTCTCTTCCGGGAAGAAGGGTACGAGGAGCTTCTGGAGCAACTCCGGCG
CACCCGCCCCCACAAGGTGGCCGCGCCCACCCTGGCCGAAGCGGGGATCGTCCTGGGCGCCCGGCTGGGCTTTGAGCGGG
TGCATCTTCTCTTTGAACTCCTAACCGAGCTCCAGGCCGAGATCGTGCCCTTCACCGAAAGGCATGCCCGGGAGGCCATC
TCCGCTTACCGGCGCTACGGGCGGGGCAAGCACCCCGCCGGGCTCAACTTTGGGGACTGCCTGAGCTACGCCCTGGCCCG
GGTGGAGGGGGAACCCCTCCTCTACAAGGGCCAGGACTTTGACCGGACGGACCTGGCGTGGAAGCCCTCCTGA

Antitoxin

Protein

• Length: 87 a.a.
• Molecular weight: 10086.61 Da
• Isoelectric Point: 5.0285

>AT38276 WP_011227983.1 NZ_AP024270:c476106-475846 [Thermus thermophilus]
MALTIRNKEVERLAEEVARLAGETKTEAVRKALEMRLRELQRKRSFDRVIRFLEEEVWPQIPPELLGKGLSKEEEEEILG
YGKEGY

Nucleotide

• Length: 261 bp

>AT38276 NZ_AP024270:c476106-475846 [Thermus thermophilus]
ATGGCCCTCACCATTCGCAACAAGGAGGTGGAGCGCCTGGCGGAGGAGGTGGCCCGCCTCGCCGGAGAAACCAAGACGGA
GGCCGTAAGGAAGGCCCTGGAGATGCGCCTTAGGGAACTCCAGAGGAAGCGGAGCTTTGACCGGGTGATCCGCTTCCTGG
AAGAGGAAGTCTGGCCCCAAATCCCGCCGGAGCTTTTGGGGAAGGGGCTCTCCAAGGAAGAGGAGGAAGAAATCCTGGGG
TACGGCAAGGAGGGGTACTGA

Structures

Antitoxin

• AlphaFold DB: A0A7R7YHV5