Detailed information of TA system TA038273

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): relBE/RelE-Phd
• Location: 3063965..3064518
• Replicon: chromosome
• Accession: NZ_AP024266
• Organism: Mycobacterium intracellulare strain M.i.27

Toxin (Protein)

• Gene name: relE
• Uniprot ID: -
• Locus tag: JN183_RS14495
• Protein ID: WP_036458935.1
• Coordinates: 3064246..3064518 (+)
• Length: 91 a.a.

Antitoxin (Protein)

• Gene name: relB
• Uniprot ID: -
• Locus tag: JN183_RS14490
• Protein ID: WP_080687338.1
• Coordinates: 3063965..3064246 (+)
• Length: 94 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
JN183_RS14475	3060822..3061829	+	1008	WP_036458927.1	GTP-binding protein	-
JN183_RS14480	3061856..3062683	+	828	WP_036458929.1	thioesterase family protein	-
JN183_RS14485	3062910..3063155	+	246	WP_036458931.1	hypothetical protein	-
JN183_RS14490	3063965..3064246	+	282	WP_080687338.1	type II toxin-antitoxin system Phd/YefM family antitoxin	Antitoxin
JN183_RS14495	3064246..3064518	+	273	WP_036458935.1	type II toxin-antitoxin system RelE/ParE family toxin	Toxin
JN183_RS14500	3064765..3065334	-	570	WP_202376191.1	hypothetical protein	-
JN183_RS14505	3065462..3066723	+	1262	WP_085989545.1	IS3 family transposase	-
JN183_RS14510	3067218..3068201	+	984	WP_051444545.1	helix-turn-helix domain-containing protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Genomic island	-	-	3061859..3123541	61682

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin-antitoxin system, RelE/ParE toxin family (8-88)

Antitoxin

• Type II toxin-antitoxin system, antitoxin Phd/YefM (2-73)

Sequences

Toxin

Protein

• Length: 91 a.a.
• Molecular weight: 10514.17 Da
• Isoelectric Point: 11.8438

>T38273 WP_036458935.1 NZ_AP024266:3064246-3064518 [Mycobacterium intracellulare]
MQPADYTVRFTATARRDLHKLPPRVLSAVIEFAFGDLAHEPRRVGKPLRRELAGLYSARRGPYRLLYRIDGGRSRVLIQR
VDHRADVYRR

Nucleotide

• Length: 273 bp

>T38273 NZ_AP024266:3064246-3064518 [Mycobacterium intracellulare]
ATGCAACCGGCGGATTACACGGTTCGGTTCACCGCCACCGCGCGGCGTGACCTGCACAAGCTGCCACCGCGCGTGCTTTC
GGCCGTGATTGAGTTCGCATTCGGCGACCTGGCGCACGAACCACGCCGCGTCGGCAAGCCGCTGCGGCGTGAACTCGCCG
GGCTGTATAGCGCCCGGCGCGGTCCGTACCGCCTCTTGTACCGGATCGACGGGGGCCGCTCACGGGTGCTGATTCAGCGT
GTCGATCATCGCGCAGATGTTTACAGGCGTTGA

Antitoxin

Protein

• Length: 94 a.a.
• Molecular weight: 10305.56 Da
• Isoelectric Point: 4.3224

>AT38273 WP_080687338.1 NZ_AP024266:3063965-3064246 [Mycobacterium intracellulare]
VRILPISKMKDKLNEYVDAVAKTQDQITITKNGAPAAVLVGAEEWESLQETLYWLSRPGIKDSIAEADADIAAGRTYDED
EIRAEFGVPRRAD

Nucleotide

• Length: 282 bp

>AT38273 NZ_AP024266:3063965-3064246 [Mycobacterium intracellulare]
GTGCGAATACTTCCCATTTCGAAGATGAAGGACAAGCTCAACGAGTACGTCGACGCGGTCGCCAAAACGCAGGATCAGAT
CACCATCACCAAGAACGGTGCGCCTGCGGCGGTGCTCGTCGGCGCCGAGGAGTGGGAATCACTCCAGGAGACGCTGTACT
GGCTTTCCAGGCCCGGGATCAAGGATTCGATCGCCGAGGCCGACGCCGACATTGCCGCTGGGCGCACTTACGACGAGGAC
GAAATTCGCGCCGAGTTCGGCGTGCCTCGGCGCGCCGACTGA