Detailed information of TA system TA038267

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): pezAT/zeta-ParD
• Location: 2649854..2650846
• Replicon: chromosome
• Accession: NZ_AP024265
• Organism: Mycobacterium intracellulare M.i.198

Toxin (Protein)

• Gene name: pezT
• Uniprot ID: -
• Locus tag: JN180_RS12540
• Protein ID: WP_014382490.1
• Coordinates: 2650268..2650846 (+)
• Length: 193 a.a.

Antitoxin (Protein)

• Gene name: pezA
• Uniprot ID: -
• Locus tag: JN180_RS12535
• Protein ID: WP_014382489.1
• Coordinates: 2649854..2650243 (+)
• Length: 130 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
JN180_RS12510	2645306..2647309	+	2004	WP_014382487.1	phosphotransferase	-
JN180_RS12515	2647306..2647851	+	546	WP_051012195.1	gluconokinase	-
JN180_RS12520	2647875..2648486	-	612	WP_009956383.1	TetR/AcrR family transcriptional regulator	-
JN180_RS12525	2648678..2649481	+	804	WP_009956382.1	SAM-dependent methyltransferase	-
JN180_RS12530	2649521..2649796	+	276	WP_014380061.1	hypothetical protein	-
JN180_RS12535	2649854..2650243	+	390	WP_014382489.1	hypothetical protein	Antitoxin
JN180_RS12540	2650268..2650846	+	579	WP_014382490.1	zeta toxin family protein	Toxin
JN180_RS12545	2650866..2651933	-	1068	WP_014380064.1	DoxX family membrane protein	-
JN180_RS12550	2652029..2652589	+	561	WP_026071602.1	pyrazinamidase PncA	-
JN180_RS12555	2652589..2653389	+	801	WP_014382492.1	nuclear transport factor 2 family protein	-
JN180_RS12560	2653401..2653751	-	351	WP_020188920.1	DoxX family protein	-
JN180_RS12565	2653917..2654888	+	972	WP_014382494.1	sigma-70 family RNA polymerase sigma factor	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Zeta toxin domain (4-137)

Antitoxin

• ParD-like antitoxin of type II bacterial toxin-antitoxin system (6-106)

Sequences

Toxin

Protein

• Length: 193 a.a.
• Molecular weight: 21077.18 Da
• Isoelectric Point: 11.0233

>T38267 WP_014382490.1 NZ_AP024265:2650268-2650846 [Mycobacterium intracellulare M.i.198]
MQRLDLVVGPNGAGKSTFIAFTLAPLLPGSPVVNADEIARQRWPGESAGRAYDAAQIAAATRAKLIDLGRSFIAETVFSH
PSKLDLIRTAHRAGFTVVLHAMLIPEDLAVERVRHRVRAGGHDVPETKVRERHRRLWTPVTDAIALSDVATVYDNSRLRG
PRIVARLSGGMTIGSPDWPAWAPEILRSRWPD

Nucleotide

• Length: 579 bp

>T38267 NZ_AP024265:2650268-2650846 [Mycobacterium intracellulare M.i.198]
ATGCAGCGACTTGACCTGGTGGTCGGGCCGAACGGTGCCGGCAAGTCGACCTTCATCGCGTTCACCCTGGCGCCGCTGTT
GCCCGGCAGCCCGGTCGTCAACGCCGATGAGATCGCAAGGCAGCGCTGGCCGGGGGAGTCGGCGGGGCGCGCCTACGACG
CCGCGCAAATCGCCGCCGCCACGCGCGCGAAGTTGATCGACCTGGGGCGGTCGTTCATCGCGGAGACCGTGTTTTCCCAC
CCGTCGAAGCTGGACCTCATCCGCACCGCCCACCGAGCGGGCTTCACCGTCGTCCTGCACGCGATGCTCATCCCGGAAGA
CCTTGCCGTCGAACGTGTCCGGCACCGCGTGCGGGCCGGTGGCCACGACGTACCGGAAACCAAGGTTCGCGAGCGCCATC
GTCGCTTGTGGACACCGGTCACCGACGCCATCGCGCTTTCCGACGTCGCCACCGTCTACGACAACAGCCGGCTGCGCGGG
CCGCGCATTGTCGCCCGCCTCAGCGGCGGCATGACGATCGGTTCACCGGACTGGCCGGCGTGGGCTCCGGAGATCTTGCG
GTCGCGCTGGCCGGACTAG

Antitoxin

Protein

• Length: 130 a.a.
• Molecular weight: 13498.86 Da
• Isoelectric Point: 5.1743

>AT38267 WP_014382489.1 NZ_AP024265:2649854-2650243 [Mycobacterium intracellulare M.i.198]
MADAPDRVTRVASDLMDSAASEGARQSRSAKQQLDHWARVGRAVSSQHTASRRRVEAALAGQLATGELTVEEGVVFNAEI
SAAIDESLVHADYGATLAGHGVTTVALNEDGDIVEHRPDGAAVVLARGR

Nucleotide

• Length: 390 bp

>AT38267 NZ_AP024265:2649854-2650243 [Mycobacterium intracellulare M.i.198]
ATGGCCGACGCTCCCGATCGTGTGACCCGCGTGGCGTCCGACCTGATGGACAGCGCGGCCTCCGAAGGCGCCCGCCAGAG
CCGTTCGGCCAAGCAGCAACTCGACCACTGGGCGCGTGTCGGGCGCGCGGTGTCCAGCCAGCACACCGCCTCGCGGCGGC
GGGTCGAGGCCGCGCTGGCCGGCCAGCTGGCGACCGGCGAACTCACCGTCGAGGAAGGCGTGGTGTTCAACGCCGAGATC
TCCGCCGCCATCGACGAAAGCCTGGTGCACGCCGACTACGGGGCGACGCTGGCCGGGCATGGCGTCACCACGGTCGCCCT
CAACGAGGACGGCGACATCGTCGAGCACCGGCCCGATGGCGCCGCCGTGGTGCTGGCGCGCGGGCGCTGA