Detailed information of TA system TA038266

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): vapBC/VapC-VapB
• Location: 1139368..1139932
• Replicon: chromosome
• Accession: NZ_AP024265
• Organism: Mycobacterium intracellulare M.i.198

Toxin (Protein)

• Gene name: vapC
• Uniprot ID: H8IVI4
• Locus tag: JN180_RS05675
• Protein ID: WP_009953437.1
• Coordinates: 1139561..1139932 (+)
• Length: 124 a.a.

Antitoxin (Protein)

• Gene name: vapB
• Uniprot ID: -
• Locus tag: JN180_RS05670
• Protein ID: WP_026071432.1
• Coordinates: 1139368..1139574 (+)
• Length: 69 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
JN180_RS05650	1135061..1135987	+	927	WP_051012169.1	4-hydroxy-3-methylbut-2-enyl diphosphate reductase	-
JN180_RS05655	1136033..1137172	-	1140	WP_179293415.1	hypothetical protein	-
JN180_RS05660	1137314..1138387	+	1074	WP_009953440.1	redox-regulated ATPase YchF	-
JN180_RS05665	1138467..1139129	-	663	WP_014379386.1	methyltransferase domain-containing protein	-
JN180_RS05670	1139368..1139574	+	207	WP_026071432.1	type II toxin-antitoxin system VapB family antitoxin	Antitoxin
JN180_RS05675	1139561..1139932	+	372	WP_009953437.1	type II toxin-antitoxin system VapC family toxin	Toxin
JN180_RS05680	1139990..1140541	+	552	WP_009953436.1	VOC family protein	-
JN180_RS05685	1140620..1141018	+	399	WP_009953435.1	VOC family protein	-
JN180_RS05690	1141117..1141500	+	384	WP_026071433.1	hypothetical protein	-
JN180_RS05695	1141586..1141945	+	360	WP_179293417.1	hypothetical protein	-
JN180_RS05700	1142127..1142702	+	576	WP_085977620.1	C40 family peptidase	-
JN180_RS05705	1143065..1143388	+	324	WP_009953431.1	antibiotic biosynthesis monooxygenase	-
JN180_RS05710	1143437..1144120	-	684	WP_014384004.1	hypothetical protein	-
JN180_RS05715	1144267..1144476	+	210	WP_014381976.1	hypothetical protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• PIN domain (2-112)

Antitoxin

• Bacterial antitoxin of type II TA system, VapB (1-42)

Sequences

Toxin

Protein

• Length: 124 a.a.
• Molecular weight: 13868.20 Da
• Isoelectric Point: 6.8398

>T38266 WP_009953437.1 NZ_AP024265:1139561-1139932 [Mycobacterium intracellulare M.i.198]
VILVDTSIWIDHLHVAEQRLVGRLTNDEIGCHQMVIEELALGMIKQRDDVLRLLSHLREFPLLTHAEILHLVDRRRLWGR
GLSAIDAHLLGSVAVVDGARLWTRDKKLKAACKEVGVAIVDES

Nucleotide

• Length: 372 bp

>T38266 NZ_AP024265:1139561-1139932 [Mycobacterium intracellulare M.i.198]
GTGATCCTCGTTGACACATCGATATGGATTGACCATCTGCACGTCGCCGAGCAGCGCCTCGTCGGCCGCTTGACCAACGA
CGAAATCGGTTGCCACCAAATGGTGATCGAGGAGCTGGCACTCGGTATGATCAAGCAGCGCGACGACGTACTGAGATTGC
TGTCCCATCTGCGCGAGTTTCCGTTGTTGACGCACGCGGAAATCCTCCATCTCGTTGACCGTCGCCGCTTGTGGGGAAGG
GGATTGAGTGCAATCGACGCCCACCTTCTTGGGTCGGTTGCTGTCGTCGACGGTGCACGGCTTTGGACGAGGGACAAGAA
GTTGAAAGCGGCGTGTAAAGAAGTGGGTGTTGCGATCGTCGATGAGTCGTGA

Antitoxin

Protein

• Length: 69 a.a.
• Molecular weight: 7250.31 Da
• Isoelectric Point: 11.9169

>AT38266 WP_026071432.1 NZ_AP024265:1139368-1139574 [Mycobacterium intracellulare M.i.198]
MRTTVTIDDALLAQAAELTGVTESAALLRQGLQTLIRVESARRLAALGGTDPKASAAPRRRPPTRDPR

Nucleotide

• Length: 207 bp

>AT38266 NZ_AP024265:1139368-1139574 [Mycobacterium intracellulare M.i.198]
ATGAGGACAACAGTGACCATCGACGATGCCTTACTGGCTCAGGCGGCGGAACTGACCGGCGTGACGGAGAGTGCGGCGCT
TCTCCGTCAGGGATTGCAGACCCTCATTCGGGTAGAGAGCGCCCGCCGTCTCGCGGCGCTCGGCGGCACGGACCCCAAGG
CGTCGGCCGCCCCGCGGCGGAGGCCGCCGACCCGTGATCCTCGTTGA

Structures

Toxin

• AlphaFold DB: A0A7R7MQX9