Detailed information of TA system TA038263

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): pezAT/ParD(antitoxin)
• Location: 2980731..2981723
• Replicon: chromosome
• Accession: NZ_AP024264
• Organism: Mycobacterium intracellulare strain M026

Toxin (Protein)

• Gene name: pezT
• Uniprot ID: -
• Locus tag: JN236_RS14035
• Protein ID: WP_009956379.1
• Coordinates: 2981145..2981723 (+)
• Length: 193 a.a.

Antitoxin (Protein)

• Gene name: pezA
• Uniprot ID: A0A7I7TS83
• Locus tag: JN236_RS14030
• Protein ID: WP_009956380.1
• Coordinates: 2980731..2981120 (+)
• Length: 130 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
JN236_RS14005	2976183..2978186	+	2004	WP_009956386.1	phosphotransferase	-
JN236_RS14010	2978183..2978728	+	546	WP_044059213.1	gluconokinase	-
JN236_RS14015	2978752..2979363	-	612	WP_009956383.1	TetR/AcrR family transcriptional regulator	-
JN236_RS14020	2979555..2980358	+	804	WP_009956382.1	SAM-dependent methyltransferase	-
JN236_RS14025	2980398..2980673	+	276	WP_009956381.1	hypothetical protein	-
JN236_RS14030	2980731..2981120	+	390	WP_009956380.1	hypothetical protein	Antitoxin
JN236_RS14035	2981145..2981723	+	579	WP_009956379.1	zeta toxin family protein	Toxin
JN236_RS14040	2981743..2982810	-	1068	WP_036397470.1	DoxX family membrane protein	-
JN236_RS14045	2982906..2983466	+	561	WP_029385272.1	pyrazinamidase PncA	-
JN236_RS14050	2983466..2984266	+	801	WP_009956375.1	nuclear transport factor 2 family protein	-
JN236_RS14055	2984278..2984628	-	351	WP_009956374.1	DoxX family protein	-
JN236_RS14060	2984794..2985765	+	972	WP_029385267.1	sigma-70 family RNA polymerase sigma factor	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Zeta toxin domain (4-136)

Antitoxin

• ParD-like antitoxin of type II bacterial toxin-antitoxin system (6-106)

Sequences

Toxin

Protein

• Length: 193 a.a.
• Molecular weight: 20962.05 Da
• Isoelectric Point: 11.0233

>T38263 WP_009956379.1 NZ_AP024264:2981145-2981723 [Mycobacterium intracellulare]
MQRLDLVVGPNGAGKSTFIAFTLAPLLPGSPVVNADEIARQRWPGEAAGRAYDAAQIAAATRAKLIDLGRSFIAETVFSH
PSKLDLVRTAHRAGFTAVLHAMLIPEDLAVERVRHRVRAGGHDVPETKVRERHRRLWTPVTDAIALSDVATVYDSGRLRG
PRIVARLSGGMTIGSPDWPAWAPEILRSRWPD

Nucleotide

• Length: 579 bp

>T38263 NZ_AP024264:2981145-2981723 [Mycobacterium intracellulare]
ATGCAGCGACTTGACCTGGTAGTCGGGCCGAACGGTGCCGGCAAGTCGACCTTCATCGCGTTCACGCTGGCGCCGCTGTT
GCCCGGCAGCCCGGTCGTCAACGCCGATGAGATCGCAAGGCAGCGCTGGCCGGGGGAGGCGGCGGGGCGCGCCTACGACG
CCGCGCAAATCGCCGCCGCCACGCGCGCGAAGTTGATCGACCTGGGGCGGTCGTTCATCGCGGAGACCGTGTTTTCCCAC
CCGTCGAAGCTGGACCTCGTCCGCACCGCCCACCGAGCGGGCTTCACCGCCGTCCTGCACGCGATGCTCATCCCGGAAGA
CCTTGCCGTCGAACGTGTCCGGCACCGCGTGCGGGCCGGCGGCCACGACGTACCGGAAACCAAGGTCCGCGAGCGCCATC
GTCGCTTGTGGACACCGGTCACCGACGCCATCGCGCTCTCCGACGTCGCCACCGTCTACGACAGCGGCCGGCTGCGCGGG
CCGCGCATTGTCGCCCGCCTCAGCGGCGGCATGACGATCGGTTCACCGGACTGGCCGGCGTGGGCTCCGGAGATCTTGCG
GTCGCGCTGGCCGGACTAG

Antitoxin

Protein

• Length: 130 a.a.
• Molecular weight: 13512.89 Da
• Isoelectric Point: 5.1828

>AT38263 WP_009956380.1 NZ_AP024264:2980731-2981120 [Mycobacterium intracellulare]
MADAPDRVTRVASDLMDSAASEGARQSRSAKQQLDHWARVGRAVSSQHTASRRRVEAALAGQLATGELTVEEGVVFNAEI
SAAIEESLVHADYGATLAGHGVTTVALNEDGDIVEHRPDGAAVVLARGR

Nucleotide

• Length: 390 bp

>AT38263 NZ_AP024264:2980731-2981120 [Mycobacterium intracellulare]
ATGGCCGACGCTCCCGATCGTGTGACCCGCGTGGCGTCCGACCTGATGGACAGCGCGGCCTCCGAAGGCGCCCGCCAGAG
CCGTTCGGCCAAGCAGCAACTCGACCACTGGGCGCGTGTCGGGCGCGCGGTGTCCAGCCAGCACACCGCCTCGCGGCGGC
GGGTCGAGGCCGCGCTGGCCGGCCAGCTGGCGACCGGCGAACTCACCGTCGAGGAAGGCGTGGTGTTCAACGCCGAGATC
TCCGCCGCCATCGAAGAAAGCCTGGTGCACGCCGACTACGGGGCGACGCTGGCCGGGCATGGCGTCACCACGGTCGCCCT
CAACGAGGACGGCGACATCGTCGAGCACCGGCCCGATGGCGCCGCCGTGGTGCTGGCGCGCGGGCGCTGA

Structures

Antitoxin

• AlphaFold DB: A0A7I7TS83