Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/VapC-VapB
Location 1311808..1312372 Replicon chromosome
Accession NZ_AP024262
Organism Mycobacterium intracellulare strain M025

Toxin (Protein)


Gene name vapC Uniprot ID -
Locus tag JN216_RS06460 Protein ID WP_036458315.1
Coordinates 1312001..1312372 (+) Length 124 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID -
Locus tag JN216_RS06455 Protein ID WP_036458377.1
Coordinates 1311808..1312014 (+) Length 69 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
JN216_RS06435 1307423..1308421 + 999 WP_008254378.1 4-hydroxy-3-methylbut-2-enyl diphosphate reductase -
JN216_RS06440 1308467..1309612 - 1146 WP_196233638.1 hypothetical protein -
JN216_RS06445 1309754..1310827 + 1074 WP_036458307.1 redox-regulated ATPase YchF -
JN216_RS06450 1310907..1311569 - 663 WP_036458309.1 methyltransferase domain-containing protein -
JN216_RS06455 1311808..1312014 + 207 WP_036458377.1 type II toxin-antitoxin system VapB family antitoxin Antitoxin
JN216_RS06460 1312001..1312372 + 372 WP_036458315.1 type II toxin-antitoxin system VapC family toxin Toxin
JN216_RS06465 1312430..1312981 + 552 WP_038535279.1 VOC family protein -
JN216_RS06470 1313060..1313458 + 399 WP_009953435.1 VOC family protein -
JN216_RS06475 1313558..1313941 + 384 WP_196233639.1 hypothetical protein -
JN216_RS06480 1314015..1314359 - 345 WP_036458317.1 hypothetical protein -
JN216_RS06485 1314569..1315144 + 576 WP_136245571.1 C40 family peptidase -
JN216_RS06490 1315508..1315831 + 324 WP_009953431.1 antibiotic biosynthesis monooxygenase -
JN216_RS06495 1315879..1316562 - 684 WP_036458379.1 hypothetical protein -
JN216_RS06500 1316709..1316918 + 210 WP_080687320.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(2-111)

Antitoxin

Bacterial antitoxin of type II TA system, VapB

(1-42)


Sequences

Toxin        


Download         Length: 124 a.a.        Molecular weight: 13905.22 Da        Isoelectric Point: 6.9118

>T38256 WP_036458315.1 NZ_AP024262:1312001-1312372 [Mycobacterium intracellulare]
VILVDTSIWIDHLHVAEHRLVGRLTNDEIGCHQMVIEELALGMIKQRDDVLRLLSHLREFPLLTHAEILHLVDRRRLWGR
GLSAIDAHLLGSVAVVDGARLWTRDKKLKAACREVGVAIVDES

Download         Length: 372 bp

>T38256 NZ_AP024262:1312001-1312372 [Mycobacterium intracellulare]
GTGATCCTCGTTGACACATCGATATGGATTGACCATCTGCACGTCGCCGAGCATCGCCTCGTCGGCCGCTTGACCAACGA
CGAAATCGGTTGCCACCAAATGGTGATCGAGGAGCTGGCACTCGGTATGATCAAGCAGCGCGACGACGTACTGAGATTGC
TGTCCCATCTGCGCGAGTTTCCGTTGTTGACGCACGCGGAAATCCTCCATCTCGTTGACCGTCGCCGCTTGTGGGGAAGG
GGATTGAGCGCAATCGACGCCCACCTTCTTGGGTCGGTTGCTGTCGTCGACGGTGCACGGCTTTGGACGAGGGACAAGAA
GTTGAAAGCGGCGTGTAGAGAAGTGGGCGTTGCGATCGTCGATGAGTCGTGA

Antitoxin


Download         Length: 69 a.a.        Molecular weight: 7220.29 Da        Isoelectric Point: 11.9169

>AT38256 WP_036458377.1 NZ_AP024262:1311808-1312014 [Mycobacterium intracellulare]
MRTTVTIDDALLAQAAELTGVAESAALLRQGLQTLIRVESARRLAALGGTDPKASAAPRRRPPTRDPR

Download         Length: 207 bp

>AT38256 NZ_AP024262:1311808-1312014 [Mycobacterium intracellulare]
ATGAGGACAACAGTGACCATCGACGATGCCTTACTGGCTCAGGCGGCGGAACTGACCGGCGTGGCGGAGAGTGCGGCGCT
TCTCCGTCAGGGATTGCAGACCCTCATTCGGGTAGAGAGCGCCCGCCGTCTCGCGGCGCTCGGCGGCACGGACCCCAAGG
CGTCGGCCGCCCCGCGGCGGAGGCCGCCGACCCGTGATCCTCGTTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References