Detailed information of TA system TA038253

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): relBE/RelE-Phd
• Location: 2888989..2889542
• Replicon: chromosome
• Accession: NZ_AP024260
• Organism: Mycobacterium intracellulare strain M023

Toxin (Protein)

• Gene name: relE
• Uniprot ID: -
• Locus tag: JN198_RS13465
• Protein ID: WP_036458935.1
• Coordinates: 2889270..2889542 (+)
• Length: 91 a.a.

Antitoxin (Protein)

• Gene name: relB
• Uniprot ID: -
• Locus tag: JN198_RS13460
• Protein ID: WP_080687338.1
• Coordinates: 2888989..2889270 (+)
• Length: 94 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
JN198_RS13445	2885846..2886853	+	1008	WP_036458927.1	GTP-binding protein	-
JN198_RS13450	2886880..2887707	+	828	WP_036458929.1	thioesterase family protein	-
JN198_RS13455	2887934..2888179	+	246	WP_036458931.1	hypothetical protein	-
JN198_RS13460	2888989..2889270	+	282	WP_080687338.1	type II toxin-antitoxin system Phd/YefM family antitoxin	Antitoxin
JN198_RS13465	2889270..2889542	+	273	WP_036458935.1	type II toxin-antitoxin system RelE/ParE family toxin	Toxin
JN198_RS13470	2889789..2890460	-	672	WP_036458937.1	hypothetical protein	-
JN198_RS13475	2890892..2891875	+	984	WP_051444545.1	helix-turn-helix domain-containing protein	-
JN198_RS13480	2891969..2893216	-	1248	WP_036458938.1	thiolase family protein	-
JN198_RS13485	2893542..2894072	+	531	WP_051444546.1	hypothetical protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Genomic island	-	-	2883749..2945596	61847

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin-antitoxin system, RelE/ParE toxin family (8-88)

Antitoxin

• Type II toxin-antitoxin system, antitoxin Phd/YefM (2-73)

Sequences

Toxin

Protein

• Length: 91 a.a.
• Molecular weight: 10514.17 Da
• Isoelectric Point: 11.8438

>T38253 WP_036458935.1 NZ_AP024260:2889270-2889542 [Mycobacterium intracellulare]
MQPADYTVRFTATARRDLHKLPPRVLSAVIEFAFGDLAHEPRRVGKPLRRELAGLYSARRGPYRLLYRIDGGRSRVLIQR
VDHRADVYRR

Nucleotide

• Length: 273 bp

>T38253 NZ_AP024260:2889270-2889542 [Mycobacterium intracellulare]
ATGCAACCGGCGGATTACACGGTTCGGTTCACCGCCACCGCGCGGCGTGACCTGCACAAGCTGCCACCGCGCGTGCTTTC
GGCCGTGATTGAGTTCGCATTCGGCGACCTGGCGCACGAACCACGCCGCGTCGGCAAGCCGCTGCGGCGTGAACTCGCCG
GGCTGTATAGCGCCCGGCGCGGTCCGTACCGCCTCTTGTACCGGATCGACGGGGGCCGCTCACGGGTGCTGATTCAGCGT
GTCGATCATCGCGCAGATGTTTACAGGCGTTGA

Antitoxin

Protein

• Length: 94 a.a.
• Molecular weight: 10305.56 Da
• Isoelectric Point: 4.3224

>AT38253 WP_080687338.1 NZ_AP024260:2888989-2889270 [Mycobacterium intracellulare]
VRILPISKMKDKLNEYVDAVAKTQDQITITKNGAPAAVLVGAEEWESLQETLYWLSRPGIKDSIAEADADIAAGRTYDED
EIRAEFGVPRRAD

Nucleotide

• Length: 282 bp

>AT38253 NZ_AP024260:2888989-2889270 [Mycobacterium intracellulare]
GTGCGAATACTTCCCATTTCGAAGATGAAGGACAAGCTCAACGAGTACGTCGACGCGGTCGCCAAAACGCAGGATCAGAT
CACCATCACCAAGAACGGTGCGCCTGCGGCGGTGCTCGTCGGCGCCGAGGAGTGGGAATCACTCCAGGAGACGCTGTACT
GGCTTTCCAGGCCCGGGATCAAGGATTCGATCGCCGAGGCCGACGCCGACATTGCCGCTGGGCGCACTTACGACGAGGAC
GAAATTCGCGCCGAGTTCGGCGTGCCTCGGCGCGCCGACTGA