Detailed information of TA system TA038252

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): pezAT/ParD(antitoxin)
• Location: 2846438..2847430
• Replicon: chromosome
• Accession: NZ_AP024260
• Organism: Mycobacterium intracellulare strain M023

Toxin (Protein)

• Gene name: pezT
• Uniprot ID: -
• Locus tag: JN198_RS13245
• Protein ID: WP_009956379.1
• Coordinates: 2846852..2847430 (+)
• Length: 193 a.a.

Antitoxin (Protein)

• Gene name: pezA
• Uniprot ID: A0A7I7TS83
• Locus tag: JN198_RS13240
• Protein ID: WP_009956380.1
• Coordinates: 2846438..2846827 (+)
• Length: 130 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
JN198_RS13215	2841890..2843893	+	2004	WP_009956386.1	phosphotransferase	-
JN198_RS13220	2843890..2844435	+	546	WP_044059213.1	gluconokinase	-
JN198_RS13225	2844459..2845070	-	612	WP_009956383.1	TetR/AcrR family transcriptional regulator	-
JN198_RS13230	2845262..2846065	+	804	WP_009956382.1	SAM-dependent methyltransferase	-
JN198_RS13235	2846105..2846380	+	276	WP_009956381.1	hypothetical protein	-
JN198_RS13240	2846438..2846827	+	390	WP_009956380.1	hypothetical protein	Antitoxin
JN198_RS13245	2846852..2847430	+	579	WP_009956379.1	zeta toxin family protein	Toxin
JN198_RS13250	2847450..2848517	-	1068	WP_036397470.1	DoxX family membrane protein	-
JN198_RS13255	2848613..2849173	+	561	WP_029385272.1	pyrazinamidase PncA	-
JN198_RS13260	2849173..2849973	+	801	WP_009956375.1	nuclear transport factor 2 family protein	-
JN198_RS13265	2849985..2850335	-	351	WP_009956374.1	DoxX family protein	-
JN198_RS13270	2850501..2851472	+	972	WP_029385267.1	sigma-70 family RNA polymerase sigma factor	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Zeta toxin domain (4-136)

Antitoxin

• ParD-like antitoxin of type II bacterial toxin-antitoxin system (6-106)

Sequences

Toxin

Protein

• Length: 193 a.a.
• Molecular weight: 20962.05 Da
• Isoelectric Point: 11.0233

>T38252 WP_009956379.1 NZ_AP024260:2846852-2847430 [Mycobacterium intracellulare]
MQRLDLVVGPNGAGKSTFIAFTLAPLLPGSPVVNADEIARQRWPGEAAGRAYDAAQIAAATRAKLIDLGRSFIAETVFSH
PSKLDLVRTAHRAGFTAVLHAMLIPEDLAVERVRHRVRAGGHDVPETKVRERHRRLWTPVTDAIALSDVATVYDSGRLRG
PRIVARLSGGMTIGSPDWPAWAPEILRSRWPD

Nucleotide

• Length: 579 bp

>T38252 NZ_AP024260:2846852-2847430 [Mycobacterium intracellulare]
ATGCAGCGACTTGACCTGGTAGTCGGGCCGAACGGTGCCGGCAAGTCGACCTTCATCGCGTTCACGCTGGCGCCGCTGTT
GCCCGGCAGCCCGGTCGTCAACGCCGATGAGATCGCAAGGCAGCGCTGGCCGGGGGAGGCGGCGGGGCGCGCCTACGACG
CCGCGCAAATCGCCGCCGCCACGCGCGCGAAGTTGATCGACCTGGGGCGGTCGTTCATCGCGGAGACCGTGTTTTCCCAC
CCGTCGAAGCTGGACCTCGTCCGCACCGCCCACCGAGCGGGCTTCACCGCCGTCCTGCACGCGATGCTCATCCCGGAAGA
CCTTGCCGTCGAACGTGTCCGGCACCGCGTGCGGGCCGGCGGCCACGACGTACCGGAAACCAAGGTCCGCGAGCGCCATC
GTCGCTTGTGGACACCGGTCACCGACGCCATCGCGCTCTCCGACGTCGCCACCGTCTACGACAGCGGCCGGCTGCGCGGG
CCGCGCATTGTCGCCCGCCTCAGCGGCGGCATGACGATCGGTTCACCGGACTGGCCGGCGTGGGCTCCGGAGATCTTGCG
GTCGCGCTGGCCGGACTAG

Antitoxin

Protein

• Length: 130 a.a.
• Molecular weight: 13512.89 Da
• Isoelectric Point: 5.1828

>AT38252 WP_009956380.1 NZ_AP024260:2846438-2846827 [Mycobacterium intracellulare]
MADAPDRVTRVASDLMDSAASEGARQSRSAKQQLDHWARVGRAVSSQHTASRRRVEAALAGQLATGELTVEEGVVFNAEI
SAAIEESLVHADYGATLAGHGVTTVALNEDGDIVEHRPDGAAVVLARGR

Nucleotide

• Length: 390 bp

>AT38252 NZ_AP024260:2846438-2846827 [Mycobacterium intracellulare]
ATGGCCGACGCTCCCGATCGTGTGACCCGCGTGGCGTCCGACCTGATGGACAGCGCGGCCTCCGAAGGCGCCCGCCAGAG
CCGTTCGGCCAAGCAGCAACTCGACCACTGGGCGCGTGTCGGGCGCGCGGTGTCCAGCCAGCACACCGCCTCGCGGCGGC
GGGTCGAGGCCGCGCTGGCCGGCCAGCTGGCGACCGGCGAACTCACCGTCGAGGAAGGCGTGGTGTTCAACGCCGAGATC
TCCGCCGCCATCGAAGAAAGCCTGGTGCACGCCGACTACGGGGCGACGCTGGCCGGGCATGGCGTCACCACGGTCGCCCT
CAACGAGGACGGCGACATCGTCGAGCACCGGCCCGATGGCGCCGCCGTGGTGCTGGCGCGCGGGCGCTGA

Structures

Antitoxin

• AlphaFold DB: A0A7I7TS83