Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/PIN-PHD
Location 937021..937688 Replicon chromosome
Accession NZ_AP024260
Organism Mycobacterium intracellulare strain M023

Toxin (Protein)


Gene name vapC Uniprot ID D5PE24
Locus tag JN198_RS04625 Protein ID WP_007168407.1
Coordinates 937296..937688 (+) Length 131 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID D5PE23
Locus tag JN198_RS04620 Protein ID WP_007168406.1
Coordinates 937021..937296 (+) Length 92 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
JN198_RS04585 932525..932851 - 327 WP_033711234.1 hypothetical protein -
JN198_RS04590 932841..933074 - 234 Protein_901 transposase -
JN198_RS04595 933080..934255 - 1176 Protein_902 ISL3 family transposase -
JN198_RS04600 934442..935074 - 633 Protein_903 DDE-type integrase/transposase/recombinase -
JN198_RS04605 935026..935166 - 141 WP_145958858.1 SDR family oxidoreductase -
JN198_RS04610 935210..935913 - 704 Protein_905 histidine phosphatase family protein -
JN198_RS04615 935996..936868 + 873 WP_007168405.1 MaoC family dehydratase N-terminal domain-containing protein -
JN198_RS04620 937021..937296 + 276 WP_007168406.1 type II toxin-antitoxin system Phd/YefM family antitoxin Antitoxin
JN198_RS04625 937296..937688 + 393 WP_007168407.1 type II toxin-antitoxin system VapC family toxin Toxin
JN198_RS04630 937836..938995 - 1160 Protein_909 trehalose-phosphatase -
JN198_RS04635 939037..940375 - 1339 Protein_910 DUF1298 domain-containing protein -
JN198_RS04640 940636..940758 - 123 Protein_911 IS1595 family transposase -
JN198_RS04645 941095..942429 + 1335 Protein_912 IS1182 family transposase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(4-119)

Antitoxin

Type II toxin-antitoxin system, antitoxin Phd/YefM

(1-45)


Sequences

Toxin        


Download         Length: 131 a.a.        Molecular weight: 14305.73 Da        Isoelectric Point: 10.5032

>T38249 WP_007168407.1 NZ_AP024260:937296-937688 [Mycobacterium intracellulare]
MAAIYLDSSAIVKLAVREPESDALRRYLRTRLPRVSSALARTEVMRALLHKGESARRAGRRALASLDLLRIDNRLLDLAG
GLLPIELRTLDAIHLATAQRLGMDLGRLCTYDDRMRDAAEALGMAVIAPS

Download         Length: 393 bp

>T38249 NZ_AP024260:937296-937688 [Mycobacterium intracellulare]
ATGGCGGCCATCTACCTGGACTCGTCCGCAATCGTCAAGCTTGCAGTTCGTGAGCCAGAGTCGGATGCGCTGCGTCGCTA
CCTTCGCACCCGGCTGCCGCGGGTGTCGAGTGCCCTTGCGCGGACGGAGGTCATGCGGGCTCTGCTCCACAAGGGTGAAT
CAGCCCGAAGAGCCGGACGCCGGGCGCTCGCGAGCCTAGACCTACTACGCATCGACAACCGATTGCTCGATCTTGCTGGT
GGGCTGCTGCCAATCGAGCTACGCACCCTCGATGCAATTCACCTGGCGACTGCCCAGCGGCTCGGCATGGATCTTGGCCG
GTTGTGCACTTACGACGACCGCATGCGCGACGCCGCCGAGGCGCTCGGCATGGCAGTGATTGCCCCGTCTTGA

Antitoxin


Download         Length: 92 a.a.        Molecular weight: 10150.63 Da        Isoelectric Point: 5.1881

>AT38249 WP_007168406.1 NZ_AP024260:937021-937296 [Mycobacterium intracellulare]
MSTVGVRELRQRASELLRRVEAGETIEITDRGRPIALLSPMPEGGPYQQMLASGGIERATLDFDDLPEPVRLKTGIELPS
VTLARLREHER

Download         Length: 276 bp

>AT38249 NZ_AP024260:937021-937296 [Mycobacterium intracellulare]
ATGTCTACGGTGGGCGTTCGTGAGCTGCGGCAGCGGGCCAGCGAACTCCTCCGTCGGGTCGAGGCCGGCGAGACGATCGA
GATCACCGACCGTGGTCGGCCTATCGCCCTTCTCTCGCCGATGCCGGAGGGCGGTCCGTACCAGCAGATGCTGGCAAGCG
GCGGGATCGAACGTGCGACGCTTGACTTTGATGACCTTCCCGAGCCGGTCCGACTCAAAACGGGTATCGAGCTGCCGTCC
GTGACGCTTGCGCGCCTGCGTGAGCACGAGCGTTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A1X1XV84

Antitoxin

Source ID Structure
AlphaFold DB A0A1X1XUZ3

References