Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) pezAT/ParD(antitoxin)
Location 2600347..2601339 Replicon chromosome
Accession NZ_AP024259
Organism Mycobacterium paraintracellulare strain M021

Toxin (Protein)


Gene name pezT Uniprot ID -
Locus tag JN177_RS12080 Protein ID WP_202377311.1
Coordinates 2600761..2601339 (+) Length 193 a.a.

Antitoxin (Protein)


Gene name pezA Uniprot ID -
Locus tag JN177_RS12075 Protein ID WP_201408208.1
Coordinates 2600347..2600736 (+) Length 130 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
JN177_RS12050 2595800..2597803 + 2004 WP_202377309.1 phosphotransferase -
JN177_RS12055 2597800..2598345 + 546 WP_202377310.1 gluconokinase -
JN177_RS12060 2598369..2598980 - 612 WP_014384642.1 TetR/AcrR family transcriptional regulator -
JN177_RS12065 2599171..2599974 + 804 WP_202377378.1 SAM-dependent methyltransferase -
JN177_RS12070 2600014..2600289 + 276 WP_201408230.1 hypothetical protein -
JN177_RS12075 2600347..2600736 + 390 WP_201408208.1 hypothetical protein Antitoxin
JN177_RS12080 2600761..2601339 + 579 WP_202377311.1 zeta toxin family protein Toxin
JN177_RS12085 2601359..2602426 - 1068 WP_201408210.1 DoxX family membrane protein -
JN177_RS12090 2602522..2603082 + 561 WP_201408211.1 isochorismatase family protein -
JN177_RS12095 2603082..2603882 + 801 WP_201408212.1 nuclear transport factor 2 family protein -
JN177_RS12100 2603894..2604244 - 351 WP_201358466.1 DoxX family protein -
JN177_RS12105 2604410..2605381 + 972 WP_201408213.1 sigma-70 family RNA polymerase sigma factor -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Zeta toxin domain

(4-137)

Antitoxin

ParD-like antitoxin of type II bacterial toxin-antitoxin system

(6-106)


Sequences

Toxin        


Download         Length: 193 a.a.        Molecular weight: 21030.13 Da        Isoelectric Point: 10.8940

>T38248 WP_202377311.1 NZ_AP024259:2600761-2601339 [Mycobacterium paraintracellulare]
MQRLDLVVGPNGAGKSTFIAFTLAPLLPGSPVVNADEIARQRWPGESAGRAYDAAKIAAATRAKLIDLGRSFIAETVFSH
PSKLDLIRTAHRAGFTAVLHAMLIPEDLAVERVRHRVRAGGHDVPETKVRERHRRLWTPVTDAIALSDVATVYDNSRLRG
PRIVARLSGGMTIGSPDWPAWAPEILRSHWPD

Download         Length: 579 bp

>T38248 NZ_AP024259:2600761-2601339 [Mycobacterium paraintracellulare]
ATGCAGCGACTTGACCTGGTGGTCGGGCCGAACGGTGCCGGCAAGTCGACCTTCATCGCGTTCACCCTGGCGCCGCTGTT
GCCCGGCAGCCCGGTCGTCAACGCCGACGAGATCGCAAGGCAGCGCTGGCCGGGGGAGTCGGCGGGGCGCGCCTACGACG
CCGCGAAAATCGCCGCCGCCACGCGGGCGAAGTTGATCGACCTGGGGCGGTCGTTCATCGCGGAGACCGTGTTCTCCCAC
CCGTCGAAGCTGGACCTCATCCGCACCGCCCACCGAGCGGGCTTCACCGCCGTCCTGCACGCGATGCTCATCCCGGAAGA
CCTTGCCGTCGAACGTGTCCGGCACCGCGTGCGGGCCGGCGGCCACGACGTACCGGAAACCAAGGTTCGCGAGCGCCATC
GTCGCTTGTGGACACCGGTCACCGACGCCATCGCGCTTTCCGACGTCGCCACCGTCTACGACAACAGCCGGCTGCGCGGG
CCGCGCATTGTCGCCCGCCTCAGCGGCGGCATGACGATCGGTTCACCGGACTGGCCGGCGTGGGCTCCGGAGATCTTGCG
GTCACACTGGCCGGACTAG

Antitoxin


Download         Length: 130 a.a.        Molecular weight: 13483.85 Da        Isoelectric Point: 5.5504

>AT38248 WP_201408208.1 NZ_AP024259:2600347-2600736 [Mycobacterium paraintracellulare]
MADAPDRVTRVASDLMDSAASEGARQSRSAKQQLDHWARVGRAVSSQHTASRRRVEAALAGQLATGELTVEEGVVFNAEV
SAAIDESLVHANYGATLAGHGVTTVALNEDGDIVEHRPDGAAVVLARGR

Download         Length: 390 bp

>AT38248 NZ_AP024259:2600347-2600736 [Mycobacterium paraintracellulare]
ATGGCCGACGCTCCCGATCGTGTGACCCGCGTGGCGTCCGACCTGATGGACAGCGCGGCCTCCGAAGGCGCCCGCCAGAG
CCGTTCGGCCAAGCAGCAACTCGACCACTGGGCGCGTGTCGGGCGCGCGGTGTCCAGCCAGCACACCGCCTCGCGTCGGC
GGGTCGAGGCCGCGCTGGCCGGCCAGCTGGCGACCGGCGAACTCACCGTCGAAGAAGGCGTGGTGTTCAACGCCGAGGTC
TCCGCGGCCATCGACGAAAGCCTGGTGCACGCCAACTACGGGGCGACGCTGGCCGGGCATGGCGTCACCACGGTCGCCCT
CAACGAGGACGGCGACATCGTCGAGCACCGGCCCGATGGCGCCGCCGTGGTGCTGGCGCGCGGGCGCTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References