Detailed information of TA system TA038247

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): vapBC/VapC-VapB
• Location: 1416233..1416797
• Replicon: chromosome
• Accession: NZ_AP024259
• Organism: Mycobacterium paraintracellulare strain M021

Toxin (Protein)

• Gene name: vapC
• Uniprot ID: H8IVI4
• Locus tag: JN177_RS06915
• Protein ID: WP_009953437.1
• Coordinates: 1416426..1416797 (+)
• Length: 124 a.a.

Antitoxin (Protein)

• Gene name: vapB
• Uniprot ID: -
• Locus tag: JN177_RS06910
• Protein ID: WP_026071432.1
• Coordinates: 1416233..1416439 (+)
• Length: 69 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
JN177_RS06890	1411854..1412852	+	999	WP_008254378.1	4-hydroxy-3-methylbut-2-enyl diphosphate reductase	-
JN177_RS06895	1412898..1414037	-	1140	WP_179300624.1	hypothetical protein	-
JN177_RS06900	1414179..1415252	+	1074	WP_009953440.1	redox-regulated ATPase YchF	-
JN177_RS06905	1415332..1415994	-	663	WP_014379386.1	methyltransferase domain-containing protein	-
JN177_RS06910	1416233..1416439	+	207	WP_026071432.1	type II toxin-antitoxin system VapB family antitoxin	Antitoxin
JN177_RS06915	1416426..1416797	+	372	WP_009953437.1	type II toxin-antitoxin system VapC family toxin	Toxin
JN177_RS06920	1416855..1417406	+	552	WP_009953436.1	VOC family protein	-
JN177_RS06925	1417485..1417883	+	399	WP_009953435.1	VOC family protein	-
JN177_RS06930	1417982..1418365	+	384	WP_026071433.1	hypothetical protein	-
JN177_RS06935	1418451..1418810	+	360	WP_198139476.1	hypothetical protein	-
JN177_RS06940	1418992..1419567	+	576	WP_136245571.1	C40 family peptidase	-
JN177_RS06945	1419932..1420255	+	324	WP_202377156.1	antibiotic biosynthesis monooxygenase	-
JN177_RS06950	1420252..1420938	-	687	WP_064939565.1	hypothetical protein	-
JN177_RS06955	1421085..1421288	+	204	WP_064939563.1	hypothetical protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• PIN domain (2-112)

Antitoxin

• Bacterial antitoxin of type II TA system, VapB (1-42)

Sequences

Toxin

Protein

• Length: 124 a.a.
• Molecular weight: 13868.20 Da
• Isoelectric Point: 6.8398

>T38247 WP_009953437.1 NZ_AP024259:1416426-1416797 [Mycobacterium paraintracellulare]
VILVDTSIWIDHLHVAEQRLVGRLTNDEIGCHQMVIEELALGMIKQRDDVLRLLSHLREFPLLTHAEILHLVDRRRLWGR
GLSAIDAHLLGSVAVVDGARLWTRDKKLKAACKEVGVAIVDES

Nucleotide

• Length: 372 bp

>T38247 NZ_AP024259:1416426-1416797 [Mycobacterium paraintracellulare]
GTGATCCTCGTTGACACATCGATATGGATTGACCATCTGCACGTCGCCGAGCAGCGCCTCGTCGGCCGCTTGACCAACGA
CGAAATCGGTTGCCACCAAATGGTGATCGAGGAGCTGGCACTCGGTATGATCAAGCAGCGCGACGACGTACTGAGATTGC
TGTCCCATCTGCGCGAGTTTCCGTTGTTGACGCACGCGGAAATCCTCCATCTCGTTGACCGTCGCCGCTTGTGGGGAAGG
GGATTGAGTGCAATCGACGCCCACCTTCTTGGGTCGGTTGCTGTCGTCGACGGTGCACGGCTTTGGACGAGGGACAAGAA
GTTGAAAGCGGCGTGTAAAGAAGTGGGTGTTGCGATCGTCGATGAGTCGTGA

Antitoxin

Protein

• Length: 69 a.a.
• Molecular weight: 7250.31 Da
• Isoelectric Point: 11.9169

>AT38247 WP_026071432.1 NZ_AP024259:1416233-1416439 [Mycobacterium paraintracellulare]
MRTTVTIDDALLAQAAELTGVTESAALLRQGLQTLIRVESARRLAALGGTDPKASAAPRRRPPTRDPR

Nucleotide

• Length: 207 bp

>AT38247 NZ_AP024259:1416233-1416439 [Mycobacterium paraintracellulare]
ATGAGGACAACAGTGACCATCGACGATGCCTTACTGGCTCAGGCGGCGGAACTGACCGGCGTGACGGAGAGTGCGGCGCT
TCTCCGTCAGGGATTGCAGACCCTCATTCGGGTAGAGAGCGCCCGCCGTCTCGCGGCGCTCGGCGGCACGGACCCCAAGG
CGTCGGCCGCCCCGCGGCGGAGGCCGCCGACCCGTGATCCTCGTTGA

Structures

Toxin

• AlphaFold DB: A0A7R7MQX9