Detailed information of TA system TA038245

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): pezAT/zeta-ParD
• Location: 2494932..2495924
• Replicon: chromosome
• Accession: NZ_AP024258
• Organism: Mycobacterium paraintracellulare strain M020

Toxin (Protein)

• Gene name: pezT
• Uniprot ID: J9WIQ3
• Locus tag: JN211_RS11655
• Protein ID: WP_014941867.1
• Coordinates: 2495346..2495924 (+)
• Length: 193 a.a.

Antitoxin (Protein)

• Gene name: pezA
• Uniprot ID: -
• Locus tag: JN211_RS11650
• Protein ID: WP_202349859.1
• Coordinates: 2494932..2495321 (+)
• Length: 130 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
JN211_RS11625	2490383..2492386	+	2004	WP_014384640.1	phosphotransferase	-
JN211_RS11630	2492383..2492883	+	501	WP_014384641.1	gluconokinase	-
JN211_RS11635	2492954..2493565	-	612	WP_009956383.1	TetR/AcrR family transcriptional regulator	-
JN211_RS11640	2493735..2494559	+	825	WP_080588061.1	SAM-dependent methyltransferase	-
JN211_RS11645	2494599..2494874	+	276	WP_038536176.1	hypothetical protein	-
JN211_RS11650	2494932..2495321	+	390	WP_202349859.1	hypothetical protein	Antitoxin
JN211_RS11655	2495346..2495924	+	579	WP_014941867.1	zeta toxin family protein	Toxin
JN211_RS11660	2495944..2497011	-	1068	WP_014380064.1	DoxX family membrane protein	-
JN211_RS11665	2497107..2497667	+	561	WP_158020468.1	pyrazinamidase PncA	-
JN211_RS11670	2497667..2498467	+	801	WP_009956375.1	nuclear transport factor 2 family protein	-
JN211_RS11675	2498479..2498829	-	351	WP_009956374.1	DoxX family protein	-
JN211_RS11680	2498995..2499966	+	972	WP_014941870.1	sigma-70 family RNA polymerase sigma factor	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Zeta toxin domain (4-138)

Antitoxin

• ParD-like antitoxin of type II bacterial toxin-antitoxin system (6-106)

Sequences

Toxin

Protein

• Length: 193 a.a.
• Molecular weight: 21005.20 Da
• Isoelectric Point: 11.0232

>T38245 WP_014941867.1 NZ_AP024258:2495346-2495924 [Mycobacterium paraintracellulare]
MQRLDLVVGPNGAGKSTFIAFTLAPLLPGSPVVNADEIARQRWPGDAAGRAYDAAQIAAATRAKLIDLGRSFIAETVFSH
PSKLDLIRTALRAGFTVVLHAMLIPEDLAVERVRHRVRAGGHDVPETKVRERHRRLWTPVTDAIALSDVATVYDNGRLRG
PRIVARLSGGMIIGSPDWPAWAPEILRSRWPD

Nucleotide

• Length: 579 bp

>T38245 NZ_AP024258:2495346-2495924 [Mycobacterium paraintracellulare]
ATGCAGCGACTTGACCTGGTGGTCGGGCCGAACGGTGCCGGCAAGTCGACCTTCATCGCGTTCACGCTGGCGCCGCTGTT
GCCCGGCAGCCCGGTCGTCAACGCCGATGAGATCGCAAGGCAGCGCTGGCCGGGGGATGCGGCGGGGCGCGCCTACGACG
CCGCGCAAATCGCCGCCGCCACGCGCGCGAAGTTGATCGACCTGGGGCGGTCGTTCATCGCGGAGACCGTGTTTTCCCAC
CCGTCGAAGCTGGACCTCATCCGCACCGCCCTCCGAGCGGGCTTCACCGTCGTCCTGCACGCGATGCTCATCCCGGAAGA
CCTTGCCGTCGAACGTGTCCGGCACCGCGTGCGGGCCGGCGGCCACGACGTACCGGAAACCAAGGTTCGCGAGCGCCATC
GTCGCTTGTGGACACCGGTCACCGACGCCATCGCGCTTTCCGACGTCGCCACCGTCTACGACAACGGCCGGCTGCGCGGG
CCGCGCATTGTCGCCCGCCTCAGCGGCGGCATGATTATCGGTTCACCGGACTGGCCGGCGTGGGCTCCGGAGATCTTGCG
GTCGCGCTGGCCGGACTAG

Antitoxin

Protein

• Length: 130 a.a.
• Molecular weight: 13482.87 Da
• Isoelectric Point: 5.1828

>AT38245 WP_202349859.1 NZ_AP024258:2494932-2495321 [Mycobacterium paraintracellulare]
MADAPDRVTRVASDLMDSAASEGARQSRSAKQQLDHWARVGRAVSSQHTASRRRVEAALAGQLATGELTVEEGVVFNAEI
SAAIEESLVHADYGATLAGHGVTAVALNEDGDIVEHRPDGAAVVLARGR

Nucleotide

• Length: 390 bp

>AT38245 NZ_AP024258:2494932-2495321 [Mycobacterium paraintracellulare]
ATGGCCGACGCTCCCGATCGTGTGACCCGCGTGGCGTCCGACCTGATGGACAGCGCGGCCTCCGAAGGCGCCCGCCAGAG
CCGTTCGGCCAAGCAGCAACTCGACCACTGGGCGCGTGTCGGGCGCGCGGTGTCCAGCCAGCACACCGCCTCGCGTCGGC
GGGTCGAGGCCGCGCTGGCCGGCCAGCTGGCGACCGGCGAACTCACCGTCGAGGAAGGCGTGGTGTTCAACGCCGAGATC
TCCGCCGCCATCGAAGAAAGCCTGGTGCACGCCGACTACGGGGCGACGCTGGCCGGGCATGGCGTCACCGCGGTCGCCCT
CAACGAGGACGGCGACATCGTCGAGCACCGGCCCGACGGCGCCGCCGTGGTGCTGGCGCGCGGGCGCTGA

Structures

Toxin

• AlphaFold DB: J9WIQ3