Detailed information of TA system TA038244

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): vapBC/VapC-PHD
• Location: 2151894..2152558
• Replicon: chromosome
• Accession: NZ_AP024258
• Organism: Mycobacterium paraintracellulare strain M020

Toxin (Protein)

• Gene name: vapC
• Uniprot ID: J9WD27
• Locus tag: JN211_RS10210
• Protein ID: WP_009954498.1
• Coordinates: 2152151..2152558 (+)
• Length: 136 a.a.

Antitoxin (Protein)

• Gene name: vapB
• Uniprot ID: -
• Locus tag: JN211_RS10205
• Protein ID: WP_083862994.1
• Coordinates: 2151894..2152154 (+)
• Length: 87 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
JN211_RS10180	2148409..2148900	-	492	WP_202349820.1	DUF1707 domain-containing protein	-
JN211_RS10185	2148970..2149566	+	597	WP_202284987.1	TetR/AcrR family transcriptional regulator	-
JN211_RS10190	2149571..2150839	-	1269	WP_202349821.1	cytochrome P450	-
JN211_RS10195	2150997..2151449	+	453	WP_201408989.1	VOC family protein	-
JN211_RS10200	2151481..2151771	+	291	Protein_2005	hypothetical protein	-
JN211_RS10205	2151894..2152154	+	261	WP_083862994.1	type II toxin-antitoxin system Phd/YefM family antitoxin	Antitoxin
JN211_RS10210	2152151..2152558	+	408	WP_009954498.1	type II toxin-antitoxin system VapC family toxin	Toxin
JN211_RS10215	2152736..2155837	+	3102	WP_201408990.1	DEAD/DEAH box helicase	-
JN211_RS10220	2155899..2157463	-	1565	Protein_2009	protein kinase	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Prophage	-	-	2150997..2164424	13427

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• PIN domain (9-125)

Antitoxin

• Type II toxin-antitoxin system, antitoxin Phd/YefM (1-66)

Sequences

Toxin

Protein

• Length: 136 a.a.
• Molecular weight: 14293.28 Da
• Isoelectric Point: 4.2772

>T38244 WP_009954498.1 NZ_AP024258:2152151-2152558 [Mycobacterium paraintracellulare]
MSNPQVAGVLDTSVFIATESGRPLDAALIPDQVGTTVVTLAELHVGVLAASTSDIRAQRLATLESIADIEALPVDDDAAR
MWARLRIHLAETGQRVRINDLWIAAIAASRGLPVVTQDDDFAVLDGAANLTVIRV

Nucleotide

• Length: 408 bp

>T38244 NZ_AP024258:2152151-2152558 [Mycobacterium paraintracellulare]
ATGAGCAACCCGCAGGTGGCCGGAGTGCTCGACACTTCGGTGTTCATCGCGACCGAAAGTGGTCGGCCTCTCGACGCGGC
GCTGATCCCTGATCAAGTTGGCACTACGGTTGTTACCCTCGCGGAACTGCACGTTGGTGTGTTGGCCGCGTCGACTTCCG
ATATTAGAGCGCAGCGCCTCGCGACATTGGAATCCATTGCGGATATTGAAGCGCTGCCGGTCGATGACGATGCGGCCCGG
ATGTGGGCCCGGCTGCGGATCCATCTCGCCGAGACCGGTCAACGCGTCCGGATCAACGATCTGTGGATCGCGGCCATCGC
GGCGTCCCGAGGGCTACCTGTTGTCACGCAGGACGATGACTTTGCCGTCTTGGATGGTGCGGCCAATTTGACCGTTATCC
GCGTCTGA

Antitoxin

Protein

• Length: 87 a.a.
• Molecular weight: 9525.87 Da
• Isoelectric Point: 10.9921

>AT38244 WP_083862994.1 NZ_AP024258:2151894-2152154 [Mycobacterium paraintracellulare]
MSEVASRELRNDTAGVLRRVRDGEDVTITVSGRPVAVLTAVVPQRRRWLSKTELLSRLPRVQADPGLREDLHALAGDTTE
QLGPIR

Nucleotide

• Length: 261 bp

>AT38244 NZ_AP024258:2151894-2152154 [Mycobacterium paraintracellulare]
ATGTCTGAAGTGGCATCTCGTGAGCTGCGCAACGATACGGCTGGGGTGCTGCGGCGGGTTCGGGATGGAGAGGACGTCAC
CATCACTGTCAGTGGCCGACCGGTCGCAGTTCTTACCGCAGTTGTCCCTCAGCGCAGGCGTTGGCTGAGCAAGACGGAGT
TGCTGTCGCGCTTGCCCCGCGTTCAAGCGGATCCGGGATTACGCGAGGACCTTCACGCACTCGCCGGCGACACTACCGAG
CAGCTGGGCCCGATCCGATGA

Structures

Toxin

• AlphaFold DB: J9WD27