Detailed information of TA system TA038243

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): vapBC/VapC-VapB
• Location: 1298059..1298623
• Replicon: chromosome
• Accession: NZ_AP024258
• Organism: Mycobacterium paraintracellulare strain M020

Toxin (Protein)

• Gene name: vapC
• Uniprot ID: -
• Locus tag: JN211_RS06450
• Protein ID: WP_201358822.1
• Coordinates: 1298252..1298623 (+)
• Length: 124 a.a.

Antitoxin (Protein)

• Gene name: vapB
• Uniprot ID: -
• Locus tag: JN211_RS06445
• Protein ID: WP_026071432.1
• Coordinates: 1298059..1298265 (+)
• Length: 69 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
JN211_RS06425	1293674..1294672	+	999	WP_008254378.1	4-hydroxy-3-methylbut-2-enyl diphosphate reductase	-
JN211_RS06430	1294718..1295863	-	1146	WP_202349729.1	hypothetical protein	-
JN211_RS06435	1296005..1297078	+	1074	WP_201358821.1	redox-regulated ATPase YchF	-
JN211_RS06440	1297158..1297820	-	663	WP_014384000.1	methyltransferase domain-containing protein	-
JN211_RS06445	1298059..1298265	+	207	WP_026071432.1	type II toxin-antitoxin system VapB family antitoxin	Antitoxin
JN211_RS06450	1298252..1298623	+	372	WP_201358822.1	type II toxin-antitoxin system VapC family toxin	Toxin
JN211_RS06455	1298681..1299232	+	552	WP_038535279.1	VOC family protein	-
JN211_RS06460	1299311..1299709	+	399	WP_009953435.1	VOC family protein	-
JN211_RS06465	1299856..1300191	+	336	WP_014379387.1	hypothetical protein	-
JN211_RS06470	1300277..1300636	+	360	WP_179960061.1	hypothetical protein	-
JN211_RS06475	1300818..1301393	+	576	WP_085977620.1	C40 family peptidase	-
JN211_RS06480	1301756..1302079	+	324	WP_009953431.1	antibiotic biosynthesis monooxygenase	-
JN211_RS06485	1302128..1302811	-	684	WP_014384004.1	hypothetical protein	-
JN211_RS06490	1302958..1303167	+	210	WP_014381976.1	hypothetical protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• PIN domain (2-111)

Antitoxin

• Bacterial antitoxin of type II TA system, VapB (1-42)

Sequences

Toxin

Protein

• Length: 124 a.a.
• Molecular weight: 13896.21 Da
• Isoelectric Point: 6.8398

>T38243 WP_201358822.1 NZ_AP024258:1298252-1298623 [Mycobacterium paraintracellulare]
VILVDTSIWIDHLHVAEHRLVGRLTNDEIGCHQMVIEELALGMIKQRDDVLRLLSQLREFPLLTHAEILHLVDRRRLWGR
GLSAIDAHLLGSVAVVDGARLWTRDKKLKAACREVGVAIVDES

Nucleotide

• Length: 372 bp

>T38243 NZ_AP024258:1298252-1298623 [Mycobacterium paraintracellulare]
GTGATCCTCGTTGACACATCGATATGGATTGACCATCTGCACGTCGCCGAGCATCGCCTCGTCGGCCGCTTGACCAACGA
CGAAATCGGTTGCCACCAAATGGTGATCGAGGAGCTGGCACTCGGTATGATCAAGCAGCGCGACGACGTACTGAGATTGC
TGTCCCAGCTGCGCGAGTTTCCGTTGTTGACGCACGCGGAAATCCTCCATCTCGTTGACCGTCGCCGCTTGTGGGGAAGG
GGATTGAGCGCAATCGACGCCCACCTTCTTGGGTCGGTTGCTGTCGTCGACGGTGCACGGCTTTGGACGAGGGACAAGAA
GTTGAAAGCGGCGTGTAGAGAAGTGGGCGTTGCGATCGTCGATGAGTCGTGA

Antitoxin

Protein

• Length: 69 a.a.
• Molecular weight: 7250.31 Da
• Isoelectric Point: 11.9169

>AT38243 WP_026071432.1 NZ_AP024258:1298059-1298265 [Mycobacterium paraintracellulare]
MRTTVTIDDALLAQAAELTGVTESAALLRQGLQTLIRVESARRLAALGGTDPKASAAPRRRPPTRDPR

Nucleotide

• Length: 207 bp

>AT38243 NZ_AP024258:1298059-1298265 [Mycobacterium paraintracellulare]
ATGAGGACAACAGTGACCATCGACGATGCCTTACTGGCTCAGGCGGCGGAACTGACCGGCGTGACGGAGAGTGCGGCGCT
TCTCCGTCAGGGATTGCAGACCCTCATTCGGGTAGAGAGCGCCCGCCGTCTCGCGGCGCTCGGCGGCACGGACCCCAAGG
CGTCGGCCGCCCCGCGGCGGAGGCCGCCGACCCGTGATCCTCGTTGA