Detailed information of TA system TA038242

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): unclassified/Polyketide_cyc2(toxin)
• Location: 1040674..1041327
• Replicon: chromosome
• Accession: NZ_AP024258
• Organism: Mycobacterium paraintracellulare strain M020

Toxin (Protein)

• Gene name: novel[antitoxin]
• Uniprot ID: -
• Locus tag: JN211_RS05260
• Protein ID: WP_008253911.1
• Coordinates: 1040866..1041327 (+)
• Length: 154 a.a.

Antitoxin (Protein)

• Gene name: novel[toxin]
• Uniprot ID: I2A997
• Locus tag: JN211_RS05255
• Protein ID: WP_008253910.1
• Coordinates: 1040674..1040862 (+)
• Length: 63 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
JN211_RS05245	1036647..1038224	+	1578	WP_014381859.1	serine hydrolase	-
JN211_RS05250	1038221..1040608	+	2388	WP_014711030.1	cation-translocating P-type ATPase	-
JN211_RS05255	1040674..1040862	+	189	WP_008253910.1	antitoxin	Antitoxin
JN211_RS05260	1040866..1041327	+	462	WP_008253911.1	SRPBCC family protein	Toxin
JN211_RS05265	1041412..1042182	+	771	WP_008253913.1	VOC family protein	-
JN211_RS05270	1042256..1042690	+	435	WP_008253914.1	hypothetical protein	-
JN211_RS05275	1042695..1043183	-	489	WP_008253915.1	glyoxalase/bleomycin resistance/dioxygenase family protein	-
JN211_RS05280	1043183..1044709	-	1527	WP_014381862.1	carotenoid oxygenase family protein	-
JN211_RS05285	1044711..1045931	-	1221	WP_009957327.1	acetyl-CoA acetyltransferase	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Polyketide cyclase/dehydrase (1-142)

Antitoxin

• Antitoxin Rv0909/MT0933 (4-52)

Sequences

Toxin

Protein

• Length: 154 a.a.
• Molecular weight: 16639.20 Da
• Isoelectric Point: 8.5617

>T38242 WP_008253911.1 NZ_AP024258:1040866-1041327 [Mycobacterium paraintracellulare]
MAKLSGSIDVPLPPEVAWQHASDLSRYKDWLTIHRVWRSALPDEIEKGSVVESIVEVKGMPNRIKWTVVRYKPPEGMTLN
GDGVGGVKVKLMAKIQPKGDGSLVSFDVHLGGPALFGPIGMIVAAALRGDIDQSLENFVTVFTRPDPSSNGHR

Nucleotide

• Length: 462 bp

>T38242 NZ_AP024258:1040866-1041327 [Mycobacterium paraintracellulare]
ATGGCCAAGCTTTCCGGATCCATCGATGTCCCGCTGCCGCCCGAGGTGGCCTGGCAGCACGCCTCCGACCTGTCCCGGTA
CAAGGATTGGCTGACCATCCACCGGGTGTGGCGCAGCGCATTGCCCGACGAGATCGAGAAGGGCTCGGTCGTCGAGTCGA
TTGTCGAGGTCAAGGGCATGCCCAACCGGATCAAATGGACGGTCGTGCGCTACAAGCCACCCGAGGGCATGACGCTCAAC
GGCGACGGAGTCGGCGGGGTCAAGGTCAAGCTGATGGCCAAGATCCAGCCCAAAGGGGACGGCTCCCTCGTCAGTTTCGA
CGTGCACCTCGGTGGCCCCGCACTGTTCGGCCCCATCGGCATGATCGTCGCCGCCGCACTGCGCGGCGATATCGACCAGT
CGCTGGAGAACTTCGTGACGGTGTTCACCCGGCCCGATCCGAGCAGCAACGGGCATCGCTGA

Antitoxin

Protein

• Length: 63 a.a.
• Molecular weight: 6797.44 Da
• Isoelectric Point: 4.4702

>AT38242 WP_008253910.1 NZ_AP024258:1040674-1040862 [Mycobacterium paraintracellulare]
MGFLDKAKDLLWQNADKVETAIDKAGEFVDEKTQGKYSDTIHQVQEQAKKAAGAADTGDQQN

Nucleotide

• Length: 189 bp

>AT38242 NZ_AP024258:1040674-1040862 [Mycobacterium paraintracellulare]
ATGGGATTCCTGGACAAGGCCAAGGATCTGTTGTGGCAGAACGCCGACAAGGTCGAGACGGCCATCGACAAGGCAGGCGA
GTTCGTCGACGAAAAGACGCAGGGCAAATACTCCGACACCATTCACCAGGTGCAGGAGCAGGCGAAGAAGGCGGCCGGCG
CCGCGGACACGGGCGACCAGCAGAACTGA

Structures

Antitoxin

• AlphaFold DB: A0A7I7TPT2