Detailed information of TA system TA038240

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): vapBC/VapC-PHD
• Location: 2144208..2144872
• Replicon: chromosome
• Accession: NZ_AP024257
• Organism: Mycobacterium paraintracellulare strain M019

Toxin (Protein)

• Gene name: vapC
• Uniprot ID: J9WD27
• Locus tag: JN215_RS10090
• Protein ID: WP_009954498.1
• Coordinates: 2144465..2144872 (+)
• Length: 136 a.a.

Antitoxin (Protein)

• Gene name: vapB
• Uniprot ID: -
• Locus tag: JN215_RS10085
• Protein ID: WP_083862994.1
• Coordinates: 2144208..2144468 (+)
• Length: 87 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
JN215_RS10060	2139644..2140027	-	384	Protein_1978	cytochrome P450	-
JN215_RS10065	2140125..2141117	-	993	WP_202284831.1	DUF4868 domain-containing protein	-
JN215_RS10070	2141114..2141629	-	516	WP_202284833.1	hypothetical protein	-
JN215_RS10075	2141885..2143153	-	1269	WP_202284835.1	cytochrome P450	-
JN215_RS10080	2143311..2143763	+	453	WP_201408989.1	VOC family protein	-
JN215_RS10085	2144208..2144468	+	261	WP_083862994.1	type II toxin-antitoxin system Phd/YefM family antitoxin	Antitoxin
JN215_RS10090	2144465..2144872	+	408	WP_009954498.1	type II toxin-antitoxin system VapC family toxin	Toxin
JN215_RS10095	2145050..2148151	+	3102	WP_201408990.1	DEAD/DEAH box helicase	-
JN215_RS10100	2148213..2149778	-	1566	WP_201407531.1	serine/threonine protein kinase	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Genomic island	-	-	2140125..2149778	9653

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• PIN domain (9-125)

Antitoxin

• Type II toxin-antitoxin system, antitoxin Phd/YefM (1-66)

Sequences

Toxin

Protein

• Length: 136 a.a.
• Molecular weight: 14293.28 Da
• Isoelectric Point: 4.2772

>T38240 WP_009954498.1 NZ_AP024257:2144465-2144872 [Mycobacterium paraintracellulare]
MSNPQVAGVLDTSVFIATESGRPLDAALIPDQVGTTVVTLAELHVGVLAASTSDIRAQRLATLESIADIEALPVDDDAAR
MWARLRIHLAETGQRVRINDLWIAAIAASRGLPVVTQDDDFAVLDGAANLTVIRV

Nucleotide

• Length: 408 bp

>T38240 NZ_AP024257:2144465-2144872 [Mycobacterium paraintracellulare]
ATGAGCAACCCGCAGGTGGCCGGAGTGCTCGACACTTCGGTGTTCATCGCGACCGAAAGTGGTCGGCCTCTCGACGCGGC
GCTGATCCCTGATCAAGTTGGCACTACGGTTGTTACCCTCGCGGAACTGCACGTTGGTGTGTTGGCCGCGTCGACTTCCG
ATATTAGAGCGCAGCGCCTCGCGACATTGGAATCCATTGCGGATATTGAAGCGCTGCCGGTCGATGACGATGCGGCCCGG
ATGTGGGCCCGGCTGCGGATCCATCTCGCCGAGACCGGTCAACGCGTCCGGATCAACGATCTGTGGATCGCGGCCATCGC
GGCGTCCCGAGGGCTACCTGTTGTCACGCAGGACGATGACTTTGCCGTCTTGGATGGTGCGGCCAATTTGACCGTTATCC
GCGTCTGA

Antitoxin

Protein

• Length: 87 a.a.
• Molecular weight: 9525.87 Da
• Isoelectric Point: 10.9921

>AT38240 WP_083862994.1 NZ_AP024257:2144208-2144468 [Mycobacterium paraintracellulare]
MSEVASRELRNDTAGVLRRVRDGEDVTITVSGRPVAVLTAVVPQRRRWLSKTELLSRLPRVQADPGLREDLHALAGDTTE
QLGPIR

Nucleotide

• Length: 261 bp

>AT38240 NZ_AP024257:2144208-2144468 [Mycobacterium paraintracellulare]
ATGTCTGAAGTGGCATCTCGTGAGCTGCGCAACGATACGGCTGGGGTGCTGCGGCGGGTTCGGGATGGAGAGGACGTCAC
CATCACTGTCAGTGGCCGACCGGTCGCAGTTCTTACCGCAGTTGTCCCTCAGCGCAGGCGTTGGCTGAGCAAGACGGAGT
TGCTGTCGCGCTTGCCCCGCGTTCAAGCGGATCCGGGATTACGCGAGGACCTTCACGCACTCGCCGGCGACACTACCGAG
CAGCTGGGCCCGATCCGATGA

Structures

Toxin

• AlphaFold DB: J9WD27