Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/VapC-VapB
Location 1281004..1281568 Replicon chromosome
Accession NZ_AP024257
Organism Mycobacterium paraintracellulare strain M019

Toxin (Protein)


Gene name vapC Uniprot ID -
Locus tag JN215_RS06285 Protein ID WP_201358822.1
Coordinates 1281197..1281568 (+) Length 124 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID -
Locus tag JN215_RS06280 Protein ID WP_026071432.1
Coordinates 1281004..1281210 (+) Length 69 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
JN215_RS06260 1276619..1277617 + 999 WP_008254378.1 4-hydroxy-3-methylbut-2-enyl diphosphate reductase -
JN215_RS06265 1277663..1278808 - 1146 WP_193375537.1 hypothetical protein -
JN215_RS06270 1278950..1280023 + 1074 WP_201358821.1 redox-regulated ATPase YchF -
JN215_RS06275 1280103..1280765 - 663 WP_202284663.1 methyltransferase domain-containing protein -
JN215_RS06280 1281004..1281210 + 207 WP_026071432.1 type II toxin-antitoxin system VapB family antitoxin Antitoxin
JN215_RS06285 1281197..1281568 + 372 WP_201358822.1 type II toxin-antitoxin system VapC family toxin Toxin
JN215_RS06290 1281626..1282177 + 552 WP_038535279.1 VOC family protein -
JN215_RS06295 1282256..1282654 + 399 WP_009953435.1 VOC family protein -
JN215_RS06300 1282801..1283136 + 336 WP_014379387.1 hypothetical protein -
JN215_RS06305 1283222..1283581 + 360 WP_179960061.1 hypothetical protein -
JN215_RS06310 1283763..1284338 + 576 WP_085977620.1 C40 family peptidase -
JN215_RS06315 1284701..1285024 + 324 WP_009953431.1 antibiotic biosynthesis monooxygenase -
JN215_RS06320 1285073..1285756 - 684 WP_014384004.1 hypothetical protein -
JN215_RS06325 1285903..1286112 + 210 WP_014381976.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(2-111)

Antitoxin

Bacterial antitoxin of type II TA system, VapB

(1-42)


Sequences

Toxin        


Download         Length: 124 a.a.        Molecular weight: 13896.21 Da        Isoelectric Point: 6.8398

>T38239 WP_201358822.1 NZ_AP024257:1281197-1281568 [Mycobacterium paraintracellulare]
VILVDTSIWIDHLHVAEHRLVGRLTNDEIGCHQMVIEELALGMIKQRDDVLRLLSQLREFPLLTHAEILHLVDRRRLWGR
GLSAIDAHLLGSVAVVDGARLWTRDKKLKAACREVGVAIVDES

Download         Length: 372 bp

>T38239 NZ_AP024257:1281197-1281568 [Mycobacterium paraintracellulare]
GTGATCCTCGTTGACACATCGATATGGATTGACCATCTGCACGTCGCCGAGCATCGCCTCGTCGGCCGCTTGACCAACGA
CGAAATCGGTTGCCACCAAATGGTGATCGAGGAGCTGGCACTCGGTATGATCAAGCAGCGCGACGACGTACTGAGATTGC
TGTCCCAGCTGCGCGAGTTTCCGTTGTTGACGCACGCGGAAATCCTCCATCTCGTTGACCGTCGCCGCTTGTGGGGAAGG
GGATTGAGCGCAATCGACGCCCACCTTCTTGGGTCGGTTGCTGTCGTCGACGGTGCACGGCTTTGGACGAGGGACAAGAA
GTTGAAAGCGGCGTGTAGAGAAGTGGGCGTTGCGATCGTCGATGAGTCGTGA

Antitoxin


Download         Length: 69 a.a.        Molecular weight: 7250.31 Da        Isoelectric Point: 11.9169

>AT38239 WP_026071432.1 NZ_AP024257:1281004-1281210 [Mycobacterium paraintracellulare]
MRTTVTIDDALLAQAAELTGVTESAALLRQGLQTLIRVESARRLAALGGTDPKASAAPRRRPPTRDPR

Download         Length: 207 bp

>AT38239 NZ_AP024257:1281004-1281210 [Mycobacterium paraintracellulare]
ATGAGGACAACAGTGACCATCGACGATGCCTTACTGGCTCAGGCGGCGGAACTGACCGGCGTGACGGAGAGTGCGGCGCT
TCTCCGTCAGGGATTGCAGACCCTCATTCGGGTAGAGAGCGCCCGCCGTCTCGCGGCGCTCGGCGGCACGGACCCCAAGG
CGTCGGCCGCCCCGCGGCGGAGGCCGCCGACCCGTGATCCTCGTTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References