Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) pezAT/zeta-ParD
Location 2719879..2720871 Replicon chromosome
Accession NZ_AP024255
Organism Mycobacterium intracellulare strain M018

Toxin (Protein)


Gene name pezT Uniprot ID H8IK07
Locus tag JN181_RS12750 Protein ID WP_014380063.1
Coordinates 2720293..2720871 (+) Length 193 a.a.

Antitoxin (Protein)


Gene name pezA Uniprot ID H8IK06
Locus tag JN181_RS12745 Protein ID WP_014380062.1
Coordinates 2719879..2720268 (+) Length 130 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
JN181_RS12720 2715331..2717334 + 2004 WP_009956386.1 phosphotransferase -
JN181_RS12725 2717331..2717876 + 546 WP_044059213.1 gluconokinase -
JN181_RS12730 2717900..2718511 - 612 WP_009956383.1 TetR/AcrR family transcriptional regulator -
JN181_RS12735 2718703..2719506 + 804 WP_009956382.1 SAM-dependent methyltransferase -
JN181_RS12740 2719546..2719821 + 276 WP_014380061.1 hypothetical protein -
JN181_RS12745 2719879..2720268 + 390 WP_014380062.1 hypothetical protein Antitoxin
JN181_RS12750 2720293..2720871 + 579 WP_014380063.1 zeta toxin family protein Toxin
JN181_RS12755 2720891..2721958 - 1068 WP_014380064.1 DoxX family membrane protein -
JN181_RS12760 2722054..2722614 + 561 WP_014380065.1 pyrazinamidase PncA -
JN181_RS12765 2722614..2723414 + 801 WP_014380066.1 nuclear transport factor 2 family protein -
JN181_RS12770 2723426..2723776 - 351 WP_041787061.1 DoxX family protein -
JN181_RS12775 2723942..2724913 + 972 WP_014380069.1 sigma-70 family RNA polymerase sigma factor -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Zeta toxin domain

(4-138)

Antitoxin

ParD-like antitoxin of type II bacterial toxin-antitoxin system

(6-106)


Sequences

Toxin        


Download         Length: 193 a.a.        Molecular weight: 21017.13 Da        Isoelectric Point: 11.0233

>T38237 WP_014380063.1 NZ_AP024255:2720293-2720871 [Mycobacterium intracellulare]
MQRLDLVVGPNGAGKSTFIAFTLAPLLPGSPVVNADEIARQRWPGEAAGRAYDAAQIAAATRAKLIDLGRSFIAETVFSH
PSKLDLVRTAHRAGFTVVLHAMLIPEDLAVERVRHRVRAGGHDVPETKVRERHRRLWTPVTDAIALSDVATVYDNGRLRG
PRIVARLSGGMTIGSPDWPAWAPEILRSRWPD

Download         Length: 579 bp

>T38237 NZ_AP024255:2720293-2720871 [Mycobacterium intracellulare]
ATGCAGCGACTTGACCTGGTAGTCGGGCCGAACGGTGCCGGCAAGTCGACCTTCATCGCGTTCACGCTGGCGCCGCTGTT
GCCCGGCAGCCCGGTCGTCAACGCCGATGAGATCGCAAGGCAGCGCTGGCCGGGGGAGGCGGCGGGGCGCGCCTACGACG
CCGCGCAAATCGCCGCCGCCACGCGCGCGAAGTTGATCGACCTGGGGCGGTCGTTCATCGCGGAGACCGTGTTTTCCCAC
CCGTCGAAGCTGGACCTCGTCCGCACCGCCCACCGAGCGGGCTTCACCGTCGTCCTGCACGCGATGCTCATCCCGGAAGA
CCTTGCCGTCGAACGTGTCCGGCACCGCGTGCGGGCCGGCGGCCACGACGTACCGGAAACCAAGGTTCGCGAGCGCCATC
GTCGCTTGTGGACACCGGTCACCGACGCCATCGCGCTCTCCGACGTCGCCACCGTCTACGACAACGGCCGGCTGCGCGGG
CCGCGCATTGTCGCCCGCCTCAGCGGCGGCATGACGATCGGTTCACCGGACTGGCCGGCGTGGGCTCCGGAGATCTTGCG
GTCGCGCTGGCCGGACTAG

Antitoxin


Download         Length: 130 a.a.        Molecular weight: 13572.99 Da        Isoelectric Point: 5.1828

>AT38237 WP_014380062.1 NZ_AP024255:2719879-2720268 [Mycobacterium intracellulare]
MADAPDRVTRVASDLMDSAASEGARQSRSAKQQLDHWARVGRAVSSQHTASRRRVEAALAGQLATGELTVEEGVVFNAEI
FAAIEESLVHADYGATLAGHGVTTVALNEDGDIVEHRPDGAAVVLARGR

Download         Length: 390 bp

>AT38237 NZ_AP024255:2719879-2720268 [Mycobacterium intracellulare]
ATGGCCGACGCTCCCGATCGTGTGACCCGCGTGGCGTCCGACCTGATGGACAGCGCGGCCTCCGAAGGCGCCCGCCAGAG
CCGTTCGGCCAAGCAGCAACTCGACCACTGGGCGCGTGTCGGGCGCGCGGTGTCCAGCCAGCACACCGCCTCGCGGCGGC
GGGTCGAGGCCGCGCTGGCCGGCCAGCTGGCGACCGGCGAACTCACCGTCGAGGAAGGCGTGGTGTTCAACGCCGAGATC
TTCGCCGCCATCGAAGAAAGCCTGGTGCACGCCGACTACGGGGCGACGCTGGCCGGGCATGGCGTCACCACGGTCGCCCT
CAACGAGGACGGCGACATCGTCGAGCACCGGCCCGATGGCGCCGCCGTGGTGCTGGCGCGCGGGCGCTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A7R7MTW2

Antitoxin

Source ID Structure
AlphaFold DB A0A7R7MVZ8

References