Detailed information of TA system TA038228

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): vapBC/VapC-PHD
• Location: 2221097..2221761
• Replicon: chromosome
• Accession: NZ_AP024253
• Organism: Mycobacterium paraintracellulare strain M015

Toxin (Protein)

• Gene name: vapC
• Uniprot ID: J9WD27
• Locus tag: JN176_RS10420
• Protein ID: WP_009954498.1
• Coordinates: 2221354..2221761 (+)
• Length: 136 a.a.

Antitoxin (Protein)

• Gene name: vapB
• Uniprot ID: -
• Locus tag: JN176_RS10415
• Protein ID: WP_083862994.1
• Coordinates: 2221097..2221357 (+)
• Length: 87 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
JN176_RS10395	2217612..2218103	-	492	WP_014941753.1	DUF1707 domain-containing protein	-
JN176_RS10400	2218173..2218769	+	597	WP_043954743.1	TetR/AcrR family transcriptional regulator	-
JN176_RS10405	2218774..2220042	-	1269	WP_014941755.1	cytochrome P450	-
JN176_RS10410	2220200..2220652	+	453	WP_014941756.1	VOC family protein	-
JN176_RS10415	2221097..2221357	+	261	WP_083862994.1	type II toxin-antitoxin system Phd/YefM family antitoxin	Antitoxin
JN176_RS10420	2221354..2221761	+	408	WP_009954498.1	type II toxin-antitoxin system VapC family toxin	Toxin
JN176_RS10425	2221939..2224050	+	2112	Protein_2051	DEAD/DEAH box helicase family protein	-
JN176_RS10430	2224189..2225541	+	1353	WP_202348956.1	DDE-type integrase/transposase/recombinase	-
JN176_RS10435	2225538..2226389	+	852	WP_014941758.1	IS21-like element helper ATPase IstB	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• PIN domain (9-125)

Antitoxin

• Type II toxin-antitoxin system, antitoxin Phd/YefM (1-66)

Sequences

Toxin

Protein

• Length: 136 a.a.
• Molecular weight: 14293.28 Da
• Isoelectric Point: 4.2772

>T38228 WP_009954498.1 NZ_AP024253:2221354-2221761 [Mycobacterium paraintracellulare]
MSNPQVAGVLDTSVFIATESGRPLDAALIPDQVGTTVVTLAELHVGVLAASTSDIRAQRLATLESIADIEALPVDDDAAR
MWARLRIHLAETGQRVRINDLWIAAIAASRGLPVVTQDDDFAVLDGAANLTVIRV

Nucleotide

• Length: 408 bp

>T38228 NZ_AP024253:2221354-2221761 [Mycobacterium paraintracellulare]
ATGAGCAACCCGCAGGTGGCCGGAGTGCTCGACACTTCGGTGTTCATCGCGACCGAAAGTGGTCGGCCTCTCGACGCGGC
GCTGATCCCTGATCAAGTTGGCACTACGGTTGTTACCCTCGCGGAACTGCACGTTGGTGTGTTGGCCGCGTCGACTTCCG
ATATTAGAGCGCAGCGCCTCGCGACATTGGAATCCATTGCGGATATCGAAGCGCTGCCGGTCGATGACGATGCGGCCCGG
ATGTGGGCCCGGCTGCGGATCCATCTCGCCGAGACCGGTCAACGCGTCCGGATCAACGATCTGTGGATCGCGGCCATCGC
GGCGTCCCGAGGGCTACCTGTTGTCACGCAGGACGATGACTTTGCCGTCTTGGATGGTGCGGCCAATTTGACCGTTATCC
GCGTCTGA

Antitoxin

Protein

• Length: 87 a.a.
• Molecular weight: 9525.87 Da
• Isoelectric Point: 10.9921

>AT38228 WP_083862994.1 NZ_AP024253:2221097-2221357 [Mycobacterium paraintracellulare]
MSEVASRELRNDTAGVLRRVRDGEDVTITVSGRPVAVLTAVVPQRRRWLSKTELLSRLPRVQADPGLREDLHALAGDTTE
QLGPIR

Nucleotide

• Length: 261 bp

>AT38228 NZ_AP024253:2221097-2221357 [Mycobacterium paraintracellulare]
ATGTCTGAAGTGGCATCTCGTGAGCTGCGCAACGATACGGCTGGGGTGCTGCGGCGGGTTCGGGATGGAGAGGACGTCAC
CATCACTGTCAGTGGCCGACCGGTCGCAGTTCTTACCGCAGTTGTCCCTCAGCGCAGGCGTTGGCTGAGCAAGACGGAGT
TGCTGTCGCGCTTGCCCCGCGTTCAAGCGGATCCGGGATTACGCGAGGACCTTCACGCACTCGCCGGCGACACTACCGAG
CAGCTGGGCCCAATCCGATGA

Structures

Toxin

• AlphaFold DB: J9WD27