Detailed information of TA system TA038225

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): pezAT/ParD(antitoxin)
• Location: 2474341..2475333
• Replicon: chromosome
• Accession: NZ_AP024251
• Organism: Mycobacterium paraintracellulare strain M011

Toxin (Protein)

• Gene name: pezT
• Uniprot ID: -
• Locus tag: JN179_RS11530
• Protein ID: WP_064938821.1
• Coordinates: 2474755..2475333 (+)
• Length: 193 a.a.

Antitoxin (Protein)

• Gene name: pezA
• Uniprot ID: A0A7I7TS83
• Locus tag: JN179_RS11525
• Protein ID: WP_009956380.1
• Coordinates: 2474341..2474730 (+)
• Length: 130 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
JN179_RS11500	2469794..2471797	+	2004	WP_201358461.1	phosphotransferase	-
JN179_RS11505	2471794..2472339	+	546	WP_201358462.1	gluconokinase	-
JN179_RS11510	2472363..2472974	-	612	WP_014384642.1	TetR/AcrR family transcriptional regulator	-
JN179_RS11515	2473165..2473968	+	804	WP_201358515.1	SAM-dependent methyltransferase	-
JN179_RS11520	2474008..2474283	+	276	WP_038536176.1	hypothetical protein	-
JN179_RS11525	2474341..2474730	+	390	WP_009956380.1	hypothetical protein	Antitoxin
JN179_RS11530	2474755..2475333	+	579	WP_064938821.1	zeta toxin family protein	Toxin
JN179_RS11535	2475353..2476420	-	1068	WP_201358463.1	DoxX family membrane protein	-
JN179_RS11540	2476516..2477076	+	561	WP_202378728.1	isochorismatase family protein	-
JN179_RS11545	2477076..2477876	+	801	WP_201408212.1	nuclear transport factor 2 family protein	-
JN179_RS11550	2477888..2478238	-	351	WP_201358466.1	DoxX family protein	-
JN179_RS11555	2478404..2479375	+	972	WP_201408213.1	sigma-70 family RNA polymerase sigma factor	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Zeta toxin domain (4-136)

Antitoxin

• ParD-like antitoxin of type II bacterial toxin-antitoxin system (6-106)

Sequences

Toxin

Protein

• Length: 193 a.a.
• Molecular weight: 20992.12 Da
• Isoelectric Point: 11.1019

>T38225 WP_064938821.1 NZ_AP024251:2474755-2475333 [Mycobacterium paraintracellulare]
MQRLDLVVGPNGAGKSTFIAFTLAPLLPGSPVVNADEIARQRWPGESAGRAYDAAKIAAATRAKLIDLGRSFIAETVFSH
PSKLDLIRTAHRAGFTAVLHAMLIPEDLAVERVRHRVRAGGHDVPETKVRERHRRLWTPVTDAIALSDVATVYDSGRLRG
PRIVARLSGGMTIGSPDWPAWAPEILRSRWPD

Nucleotide

• Length: 579 bp

>T38225 NZ_AP024251:2474755-2475333 [Mycobacterium paraintracellulare]
ATGCAGCGACTTGACCTGGTAGTCGGGCCGAACGGTGCCGGCAAGTCGACCTTCATCGCGTTCACCCTGGCGCCGCTGTT
GCCCGGCAGCCCGGTCGTCAACGCCGACGAGATCGCAAGGCAGCGCTGGCCGGGGGAGTCGGCGGGGCGCGCCTACGACG
CCGCGAAAATCGCCGCCGCCACGCGCGCGAAGTTGATCGACCTGGGGCGGTCGTTCATCGCGGAGACCGTGTTTTCCCAC
CCGTCGAAGCTGGACCTCATCCGCACCGCCCACCGAGCGGGCTTCACCGCCGTCCTGCACGCGATGCTCATCCCGGAAGA
CCTTGCCGTCGAACGTGTCCGGCACCGCGTGCGGGCCGGCGGCCACGACGTACCGGAAACCAAGGTCCGCGAGCGCCATC
GTCGCTTGTGGACACCGGTCACCGACGCCATCGCGCTCTCCGACGTCGCCACCGTCTACGACAGCGGCCGGCTGCGCGGG
CCGCGCATTGTCGCCCGCCTCAGCGGCGGCATGACGATCGGTTCACCGGACTGGCCGGCGTGGGCTCCGGAGATCTTGCG
GTCGCGCTGGCCGGACTAG

Antitoxin

Protein

• Length: 130 a.a.
• Molecular weight: 13512.89 Da
• Isoelectric Point: 5.1828

>AT38225 WP_009956380.1 NZ_AP024251:2474341-2474730 [Mycobacterium paraintracellulare]
MADAPDRVTRVASDLMDSAASEGARQSRSAKQQLDHWARVGRAVSSQHTASRRRVEAALAGQLATGELTVEEGVVFNAEI
SAAIEESLVHADYGATLAGHGVTTVALNEDGDIVEHRPDGAAVVLARGR

Nucleotide

• Length: 390 bp

>AT38225 NZ_AP024251:2474341-2474730 [Mycobacterium paraintracellulare]
ATGGCCGACGCTCCCGATCGTGTGACCCGCGTGGCGTCCGACCTGATGGACAGCGCGGCCTCCGAAGGCGCCCGCCAGAG
CCGTTCGGCCAAGCAGCAACTCGACCACTGGGCGCGTGTCGGGCGCGCGGTGTCCAGCCAGCACACCGCCTCGCGGCGGC
GGGTCGAGGCCGCGCTGGCCGGCCAGCTGGCGACCGGCGAACTCACCGTCGAGGAAGGCGTGGTGTTCAACGCCGAGATC
TCCGCCGCCATCGAAGAAAGCCTGGTGCACGCCGACTACGGGGCGACGCTGGCCGGGCATGGCGTCACCACGGTCGCCCT
CAACGAGGACGGCGACATCGTCGAGCACCGGCCCGATGGCGCCGCCGTGGTGCTGGCGCGCGGGCGCTGA

Structures

Antitoxin

• AlphaFold DB: A0A7I7TS83