Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/VapC-VapB
Location 1300837..1301401 Replicon chromosome
Accession NZ_AP024251
Organism Mycobacterium paraintracellulare strain M011

Toxin (Protein)


Gene name vapC Uniprot ID -
Locus tag JN179_RS06385 Protein ID WP_041784823.1
Coordinates 1301030..1301401 (+) Length 124 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID -
Locus tag JN179_RS06380 Protein ID WP_026071432.1
Coordinates 1300837..1301043 (+) Length 69 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
JN179_RS06360 1296452..1297450 + 999 WP_008254378.1 4-hydroxy-3-methylbut-2-enyl diphosphate reductase -
JN179_RS06365 1297496..1298641 - 1146 WP_193375537.1 hypothetical protein -
JN179_RS06370 1298783..1299856 + 1074 WP_014941407.1 redox-regulated ATPase YchF -
JN179_RS06375 1299936..1300598 - 663 WP_014384000.1 methyltransferase domain-containing protein -
JN179_RS06380 1300837..1301043 + 207 WP_026071432.1 type II toxin-antitoxin system VapB family antitoxin Antitoxin
JN179_RS06385 1301030..1301401 + 372 WP_041784823.1 type II toxin-antitoxin system VapC family toxin Toxin
JN179_RS06390 1301459..1302010 + 552 WP_038535279.1 VOC family protein -
JN179_RS06395 1302089..1302487 + 399 WP_009953435.1 VOC family protein -
JN179_RS06400 1302634..1302969 + 336 WP_014379387.1 hypothetical protein -
JN179_RS06405 1303055..1303414 + 360 WP_179960061.1 hypothetical protein -
JN179_RS06410 1303596..1304171 + 576 WP_085977620.1 C40 family peptidase -
JN179_RS06415 1304534..1304857 + 324 WP_009953431.1 antibiotic biosynthesis monooxygenase -
JN179_RS06420 1304906..1305589 - 684 WP_014384004.1 hypothetical protein -
JN179_RS06425 1305736..1305945 + 210 WP_014381976.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(2-112)

Antitoxin

Bacterial antitoxin of type II TA system, VapB

(1-42)


Sequences

Toxin        


Download         Length: 124 a.a.        Molecular weight: 13877.21 Da        Isoelectric Point: 6.9118

>T38224 WP_041784823.1 NZ_AP024251:1301030-1301401 [Mycobacterium paraintracellulare]
VILVDTSIWIDHLHVAEHRLVGRLTNDEIGCHQMVIEELALGMIKQRDDVLRLLSHLREFPLLTHAEILHLVDRRRLWGR
GLSAIDAHLLGSVAVVDGARLWTRDKKLKAACKEVGVAIVDES

Download         Length: 372 bp

>T38224 NZ_AP024251:1301030-1301401 [Mycobacterium paraintracellulare]
GTGATCCTCGTTGACACATCGATATGGATTGACCATCTGCACGTCGCCGAGCATCGCCTCGTCGGCCGCTTGACCAACGA
CGAAATCGGTTGCCACCAAATGGTGATCGAGGAGCTGGCACTCGGTATGATCAAGCAGCGCGACGACGTACTGAGATTGC
TGTCCCATCTGCGCGAGTTTCCGTTGTTGACGCACGCGGAAATCCTCCATCTCGTTGACCGTCGCCGCTTGTGGGGAAGG
GGATTGAGCGCAATCGACGCCCACCTTCTTGGGTCGGTTGCTGTCGTCGACGGTGCACGGCTTTGGACGAGGGACAAGAA
GTTGAAAGCGGCGTGTAAAGAAGTGGGTGTTGCGATCGTCGATGAGTCGTGA

Antitoxin


Download         Length: 69 a.a.        Molecular weight: 7250.31 Da        Isoelectric Point: 11.9169

>AT38224 WP_026071432.1 NZ_AP024251:1300837-1301043 [Mycobacterium paraintracellulare]
MRTTVTIDDALLAQAAELTGVTESAALLRQGLQTLIRVESARRLAALGGTDPKASAAPRRRPPTRDPR

Download         Length: 207 bp

>AT38224 NZ_AP024251:1300837-1301043 [Mycobacterium paraintracellulare]
ATGAGGACAACAGTGACCATCGACGATGCCTTACTGGCTCAGGCGGCGGAACTGACCGGCGTGACGGAGAGTGCGGCGCT
TCTCCGTCAGGGATTGCAGACCCTCATTCGGGTAGAGAGCGCCCGCCGTCTCGCGGCGCTCGGCGGCACGGACCCCAAGG
CGTCGGCCGCCCCGCGGCGGAGGCCGCCGACCCGTGATCCTCGTTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References