Detailed information of TA system TA038221

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): pezAT/zeta-ParD
• Location: 2820954..2821946
• Replicon: chromosome
• Accession: NZ_AP024250
• Organism: Mycobacterium intracellulare strain M009

Toxin (Protein)

• Gene name: pezT
• Uniprot ID: -
• Locus tag: JN213_RS13200
• Protein ID: WP_201407898.1
• Coordinates: 2821368..2821946 (+)
• Length: 193 a.a.

Antitoxin (Protein)

• Gene name: pezA
• Uniprot ID: A0A7I7TS83
• Locus tag: JN213_RS13195
• Protein ID: WP_009956380.1
• Coordinates: 2820954..2821343 (+)
• Length: 130 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
JN213_RS13170	2816407..2818410	+	2004	WP_201407740.1	phosphotransferase	-
JN213_RS13175	2818407..2818952	+	546	WP_051012195.1	gluconokinase	-
JN213_RS13180	2818976..2819587	-	612	WP_014384642.1	TetR/AcrR family transcriptional regulator	-
JN213_RS13185	2819778..2820581	+	804	WP_202287172.1	SAM-dependent methyltransferase	-
JN213_RS13190	2820621..2820896	+	276	WP_038536176.1	hypothetical protein	-
JN213_RS13195	2820954..2821343	+	390	WP_009956380.1	hypothetical protein	Antitoxin
JN213_RS13200	2821368..2821946	+	579	WP_201407898.1	zeta toxin family protein	Toxin
JN213_RS13205	2821966..2823033	-	1068	WP_014380064.1	DoxX family membrane protein	-
JN213_RS13210	2823129..2823689	+	561	WP_201407897.1	isochorismatase family protein	-
JN213_RS13215	2823689..2824489	+	801	WP_201407896.1	nuclear transport factor 2 family protein	-
JN213_RS13220	2824501..2824851	-	351	WP_009956374.1	DoxX family protein	-
JN213_RS13225	2825017..2825988	+	972	WP_202287070.1	sigma-70 family RNA polymerase sigma factor	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Zeta toxin domain (4-138)

Antitoxin

• ParD-like antitoxin of type II bacterial toxin-antitoxin system (6-106)

Sequences

Toxin

Protein

• Length: 193 a.a.
• Molecular weight: 21047.20 Da
• Isoelectric Point: 11.1019

>T38221 WP_201407898.1 NZ_AP024250:2821368-2821946 [Mycobacterium intracellulare]
MQRLDLVVGPNGAGKSTFIAFTLAPLLPGSPVVNADEIARQRWPGESAGRAYDAAKIAAATRAKLIDLGRSFIAETVFSH
PSKLDLIRTAHRAGFTVVLHAMLIPEDLAVERVRHRVRAGGHDVPETKVRERHRRLWTPVTDAIALSDVATVYDNGRLRG
PRIVARLSGGMTIGSPDWPAWAPEILRSRWPD

Nucleotide

• Length: 579 bp

>T38221 NZ_AP024250:2821368-2821946 [Mycobacterium intracellulare]
ATGCAGCGACTTGACCTGGTAGTCGGGCCGAACGGTGCCGGCAAGTCGACCTTCATCGCGTTCACCCTGGCGCCGCTGTT
GCCCGGCAGCCCGGTCGTCAACGCCGACGAGATCGCAAGGCAGCGCTGGCCGGGGGAGTCGGCGGGGCGCGCCTACGACG
CCGCGAAAATCGCCGCCGCCACGCGCGCGAAGTTGATCGACCTGGGGCGGTCGTTCATCGCGGAGACCGTGTTTTCCCAC
CCGTCGAAGCTGGACCTCATCCGCACCGCCCACCGAGCGGGCTTCACCGTCGTCCTGCACGCGATGCTCATCCCGGAAGA
CCTTGCCGTCGAACGTGTCCGGCACCGCGTGCGGGCCGGCGGCCACGACGTACCGGAAACCAAGGTCCGCGAGCGCCATC
GTCGCTTGTGGACACCGGTCACCGACGCCATCGCGCTCTCCGACGTCGCCACCGTCTACGACAACGGCCGGCTGCGCGGG
CCGCGCATTGTCGCCCGCCTCAGCGGCGGCATGACGATCGGTTCACCGGACTGGCCGGCGTGGGCTCCGGAGATCTTGCG
GTCGCGCTGGCCGGACTAG

Antitoxin

Protein

• Length: 130 a.a.
• Molecular weight: 13512.89 Da
• Isoelectric Point: 5.1828

>AT38221 WP_009956380.1 NZ_AP024250:2820954-2821343 [Mycobacterium intracellulare]
MADAPDRVTRVASDLMDSAASEGARQSRSAKQQLDHWARVGRAVSSQHTASRRRVEAALAGQLATGELTVEEGVVFNAEI
SAAIEESLVHADYGATLAGHGVTTVALNEDGDIVEHRPDGAAVVLARGR

Nucleotide

• Length: 390 bp

>AT38221 NZ_AP024250:2820954-2821343 [Mycobacterium intracellulare]
ATGGCCGACGCTCCCGATCGTGTGACCCGCGTGGCGTCCGACCTGATGGACAGCGCGGCCTCCGAAGGCGCCCGCCAGAG
CCGTTCGGCCAAGCAGCAACTCGACCACTGGGCGCGTGTCGGGCGCGCGGTGTCCAGCCAGCACACCGCCTCGCGGCGGC
GGGTCGAGGCCGCGCTGGCCGGCCAGCTGGCGACCGGCGAACTCACCGTCGAGGAAGGCGTGGTGTTCAACGCCGAGATC
TCCGCCGCCATCGAAGAAAGCCTGGTGCACGCCGACTACGGGGCGACGCTGGCCGGGCATGGCGTCACCACGGTCGCCCT
CAACGAGGACGGCGACATCGTCGAGCACCGGCCCGATGGCGCCGCCGTGGTGCTGGCGCGCGGGCGCTGA

Structures

Antitoxin

• AlphaFold DB: A0A7I7TS83