Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/PIN-PHD
Location 862157..862824 Replicon chromosome
Accession NZ_AP024250
Organism Mycobacterium intracellulare strain M009

Toxin (Protein)


Gene name vapC Uniprot ID D5PE24
Locus tag JN213_RS04300 Protein ID WP_007168407.1
Coordinates 862432..862824 (+) Length 131 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID D5PE23
Locus tag JN213_RS04295 Protein ID WP_007168406.1
Coordinates 862157..862432 (+) Length 92 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
JN213_RS04260 857661..857987 - 327 WP_033711234.1 hypothetical protein -
JN213_RS04265 857977..858210 - 234 Protein_836 transposase -
JN213_RS04270 858216..859391 - 1176 Protein_837 ISL3 family transposase -
JN213_RS04275 859578..860210 - 633 Protein_838 DDE-type integrase/transposase/recombinase -
JN213_RS04280 860162..860302 - 141 WP_145958858.1 SDR family oxidoreductase -
JN213_RS04285 860346..861049 - 704 Protein_840 histidine phosphatase family protein -
JN213_RS04290 861132..862004 + 873 WP_007168405.1 MaoC family dehydratase N-terminal domain-containing protein -
JN213_RS04295 862157..862432 + 276 WP_007168406.1 type II toxin-antitoxin system Phd/YefM family antitoxin Antitoxin
JN213_RS04300 862432..862824 + 393 WP_007168407.1 type II toxin-antitoxin system VapC family toxin Toxin
JN213_RS04305 862972..864131 - 1160 Protein_844 trehalose-phosphatase -
JN213_RS04310 864173..865511 - 1339 Protein_845 DUF1298 domain-containing protein -
JN213_RS04315 865772..865894 - 123 Protein_846 IS1595 family transposase -
JN213_RS04320 866231..867565 + 1335 Protein_847 IS1182 family transposase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(4-119)

Antitoxin

Type II toxin-antitoxin system, antitoxin Phd/YefM

(1-45)


Sequences

Toxin        


Download         Length: 131 a.a.        Molecular weight: 14305.73 Da        Isoelectric Point: 10.5032

>T38217 WP_007168407.1 NZ_AP024250:862432-862824 [Mycobacterium intracellulare]
MAAIYLDSSAIVKLAVREPESDALRRYLRTRLPRVSSALARTEVMRALLHKGESARRAGRRALASLDLLRIDNRLLDLAG
GLLPIELRTLDAIHLATAQRLGMDLGRLCTYDDRMRDAAEALGMAVIAPS

Download         Length: 393 bp

>T38217 NZ_AP024250:862432-862824 [Mycobacterium intracellulare]
ATGGCGGCCATCTACCTGGACTCGTCCGCAATCGTCAAGCTTGCAGTTCGTGAGCCAGAGTCGGATGCGCTGCGTCGCTA
CCTTCGCACCCGGCTGCCGCGGGTGTCGAGTGCCCTTGCGCGGACGGAGGTCATGCGGGCTCTGCTCCACAAGGGTGAAT
CAGCCCGAAGAGCCGGACGCCGGGCGCTCGCGAGCCTAGACCTACTACGCATCGACAACCGATTGCTCGATCTTGCTGGT
GGGCTGCTGCCAATCGAGCTACGCACCCTCGATGCAATTCACCTGGCGACTGCCCAGCGGCTCGGCATGGATCTTGGCCG
GTTGTGCACTTACGACGACCGCATGCGCGACGCCGCCGAGGCGCTCGGCATGGCAGTGATTGCCCCGTCTTGA

Antitoxin


Download         Length: 92 a.a.        Molecular weight: 10150.63 Da        Isoelectric Point: 5.1881

>AT38217 WP_007168406.1 NZ_AP024250:862157-862432 [Mycobacterium intracellulare]
MSTVGVRELRQRASELLRRVEAGETIEITDRGRPIALLSPMPEGGPYQQMLASGGIERATLDFDDLPEPVRLKTGIELPS
VTLARLREHER

Download         Length: 276 bp

>AT38217 NZ_AP024250:862157-862432 [Mycobacterium intracellulare]
ATGTCTACGGTGGGCGTTCGTGAGCTGCGGCAGCGGGCCAGCGAACTCCTCCGTCGGGTCGAGGCCGGCGAGACGATCGA
GATCACCGACCGTGGTCGGCCTATCGCCCTTCTCTCGCCGATGCCGGAGGGCGGTCCGTACCAGCAGATGCTGGCAAGCG
GCGGGATCGAACGTGCGACGCTTGACTTTGATGACCTTCCCGAGCCGGTCCGACTCAAAACGGGTATCGAGCTGCCGTCC
GTGACGCTTGCGCGCCTGCGTGAGCACGAGCGTTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A1X1XV84

Antitoxin

Source ID Structure
AlphaFold DB A0A1X1XUZ3

References