Detailed information of TA system TA038215

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): pezAT/zeta-ParD
• Location: 2928341..2929333
• Replicon: chromosome
• Accession: NZ_AP024248
• Organism: Mycobacterium intracellulare strain M008

Toxin (Protein)

• Gene name: pezT
• Uniprot ID: -
• Locus tag: JN197_RS13715
• Protein ID: WP_201407898.1
• Coordinates: 2928755..2929333 (+)
• Length: 193 a.a.

Antitoxin (Protein)

• Gene name: pezA
• Uniprot ID: A0A7I7TS83
• Locus tag: JN197_RS13710
• Protein ID: WP_009956380.1
• Coordinates: 2928341..2928730 (+)
• Length: 130 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
JN197_RS13685	2923794..2925797	+	2004	WP_201407740.1	phosphotransferase	-
JN197_RS13690	2925794..2926339	+	546	WP_051012195.1	gluconokinase	-
JN197_RS13695	2926363..2926974	-	612	WP_014384642.1	TetR/AcrR family transcriptional regulator	-
JN197_RS13700	2927165..2927968	+	804	WP_202287172.1	SAM-dependent methyltransferase	-
JN197_RS13705	2928008..2928283	+	276	WP_038536176.1	hypothetical protein	-
JN197_RS13710	2928341..2928730	+	390	WP_009956380.1	hypothetical protein	Antitoxin
JN197_RS13715	2928755..2929333	+	579	WP_201407898.1	zeta toxin family protein	Toxin
JN197_RS13720	2929353..2930420	-	1068	WP_014380064.1	DoxX family membrane protein	-
JN197_RS13725	2930516..2931076	+	561	WP_201407897.1	isochorismatase family protein	-
JN197_RS13730	2931076..2931876	+	801	WP_201407896.1	nuclear transport factor 2 family protein	-
JN197_RS13735	2931888..2932238	-	351	WP_009956374.1	DoxX family protein	-
JN197_RS13740	2932404..2933375	+	972	WP_202287070.1	sigma-70 family RNA polymerase sigma factor	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Zeta toxin domain (4-138)

Antitoxin

• ParD-like antitoxin of type II bacterial toxin-antitoxin system (6-106)

Sequences

Toxin

Protein

• Length: 193 a.a.
• Molecular weight: 21047.20 Da
• Isoelectric Point: 11.1019

>T38215 WP_201407898.1 NZ_AP024248:2928755-2929333 [Mycobacterium intracellulare]
MQRLDLVVGPNGAGKSTFIAFTLAPLLPGSPVVNADEIARQRWPGESAGRAYDAAKIAAATRAKLIDLGRSFIAETVFSH
PSKLDLIRTAHRAGFTVVLHAMLIPEDLAVERVRHRVRAGGHDVPETKVRERHRRLWTPVTDAIALSDVATVYDNGRLRG
PRIVARLSGGMTIGSPDWPAWAPEILRSRWPD

Nucleotide

• Length: 579 bp

>T38215 NZ_AP024248:2928755-2929333 [Mycobacterium intracellulare]
ATGCAGCGACTTGACCTGGTAGTCGGGCCGAACGGTGCCGGCAAGTCGACCTTCATCGCGTTCACCCTGGCGCCGCTGTT
GCCCGGCAGCCCGGTCGTCAACGCCGACGAGATCGCAAGGCAGCGCTGGCCGGGGGAGTCGGCGGGGCGCGCCTACGACG
CCGCGAAAATCGCCGCCGCCACGCGCGCGAAGTTGATCGACCTGGGGCGGTCGTTCATCGCGGAGACCGTGTTTTCCCAC
CCGTCGAAGCTGGACCTCATCCGCACCGCCCACCGAGCGGGCTTCACCGTCGTCCTGCACGCGATGCTCATCCCGGAAGA
CCTTGCCGTCGAACGTGTCCGGCACCGCGTGCGGGCCGGCGGCCACGACGTACCGGAAACCAAGGTCCGCGAGCGCCATC
GTCGCTTGTGGACACCGGTCACCGACGCCATCGCGCTCTCCGACGTCGCCACCGTCTACGACAACGGCCGGCTGCGCGGG
CCGCGCATTGTCGCCCGCCTCAGCGGCGGCATGACGATCGGTTCACCGGACTGGCCGGCGTGGGCTCCGGAGATCTTGCG
GTCGCGCTGGCCGGACTAG

Antitoxin

Protein

• Length: 130 a.a.
• Molecular weight: 13512.89 Da
• Isoelectric Point: 5.1828

>AT38215 WP_009956380.1 NZ_AP024248:2928341-2928730 [Mycobacterium intracellulare]
MADAPDRVTRVASDLMDSAASEGARQSRSAKQQLDHWARVGRAVSSQHTASRRRVEAALAGQLATGELTVEEGVVFNAEI
SAAIEESLVHADYGATLAGHGVTTVALNEDGDIVEHRPDGAAVVLARGR

Nucleotide

• Length: 390 bp

>AT38215 NZ_AP024248:2928341-2928730 [Mycobacterium intracellulare]
ATGGCCGACGCTCCCGATCGTGTGACCCGCGTGGCGTCCGACCTGATGGACAGCGCGGCCTCCGAAGGCGCCCGCCAGAG
CCGTTCGGCCAAGCAGCAACTCGACCACTGGGCGCGTGTCGGGCGCGCGGTGTCCAGCCAGCACACCGCCTCGCGGCGGC
GGGTCGAGGCCGCGCTGGCCGGCCAGCTGGCGACCGGCGAACTCACCGTCGAGGAAGGCGTGGTGTTCAACGCCGAGATC
TCCGCCGCCATCGAAGAAAGCCTGGTGCACGCCGACTACGGGGCGACGCTGGCCGGGCATGGCGTCACCACGGTCGCCCT
CAACGAGGACGGCGACATCGTCGAGCACCGGCCCGATGGCGCCGCCGTGGTGCTGGCGCGCGGGCGCTGA

Structures

Antitoxin

• AlphaFold DB: A0A7I7TS83