Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/PIN-PHD
Location 972009..972676 Replicon chromosome
Accession NZ_AP024248
Organism Mycobacterium intracellulare strain M008

Toxin (Protein)


Gene name vapC Uniprot ID D5PE24
Locus tag JN197_RS04815 Protein ID WP_007168407.1
Coordinates 972284..972676 (+) Length 131 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID D5PE23
Locus tag JN197_RS04810 Protein ID WP_007168406.1
Coordinates 972009..972284 (+) Length 92 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
JN197_RS04775 967513..967839 - 327 WP_033711234.1 hypothetical protein -
JN197_RS04780 967829..968062 - 234 Protein_939 transposase -
JN197_RS04785 968068..969243 - 1176 Protein_940 ISL3 family transposase -
JN197_RS04790 969430..970062 - 633 Protein_941 DDE-type integrase/transposase/recombinase -
JN197_RS04795 970014..970154 - 141 WP_145958858.1 SDR family oxidoreductase -
JN197_RS04800 970198..970901 - 704 Protein_943 histidine phosphatase family protein -
JN197_RS04805 970984..971856 + 873 WP_007168405.1 MaoC family dehydratase N-terminal domain-containing protein -
JN197_RS04810 972009..972284 + 276 WP_007168406.1 type II toxin-antitoxin system Phd/YefM family antitoxin Antitoxin
JN197_RS04815 972284..972676 + 393 WP_007168407.1 type II toxin-antitoxin system VapC family toxin Toxin
JN197_RS04820 972824..973983 - 1160 Protein_947 trehalose-phosphatase -
JN197_RS04825 974025..975363 - 1339 Protein_948 DUF1298 domain-containing protein -
JN197_RS04830 975624..975746 - 123 Protein_949 IS1595 family transposase -
JN197_RS04835 976083..977417 + 1335 Protein_950 IS1182 family transposase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(4-119)

Antitoxin

Type II toxin-antitoxin system, antitoxin Phd/YefM

(1-45)


Sequences

Toxin        


Download         Length: 131 a.a.        Molecular weight: 14305.73 Da        Isoelectric Point: 10.5032

>T38211 WP_007168407.1 NZ_AP024248:972284-972676 [Mycobacterium intracellulare]
MAAIYLDSSAIVKLAVREPESDALRRYLRTRLPRVSSALARTEVMRALLHKGESARRAGRRALASLDLLRIDNRLLDLAG
GLLPIELRTLDAIHLATAQRLGMDLGRLCTYDDRMRDAAEALGMAVIAPS

Download         Length: 393 bp

>T38211 NZ_AP024248:972284-972676 [Mycobacterium intracellulare]
ATGGCGGCCATCTACCTGGACTCGTCCGCAATCGTCAAGCTTGCAGTTCGTGAGCCAGAGTCGGATGCGCTGCGTCGCTA
CCTTCGCACCCGGCTGCCGCGGGTGTCGAGTGCCCTTGCGCGGACGGAGGTCATGCGGGCTCTGCTCCACAAGGGTGAAT
CAGCCCGAAGAGCCGGACGCCGGGCGCTCGCGAGCCTAGACCTACTACGCATCGACAACCGATTGCTCGATCTTGCTGGT
GGGCTGCTGCCAATCGAGCTACGCACCCTCGATGCAATTCACCTGGCGACTGCCCAGCGGCTCGGCATGGATCTTGGCCG
GTTGTGCACTTACGACGACCGCATGCGCGACGCCGCCGAGGCGCTCGGCATGGCAGTGATTGCCCCGTCTTGA

Antitoxin


Download         Length: 92 a.a.        Molecular weight: 10150.63 Da        Isoelectric Point: 5.1881

>AT38211 WP_007168406.1 NZ_AP024248:972009-972284 [Mycobacterium intracellulare]
MSTVGVRELRQRASELLRRVEAGETIEITDRGRPIALLSPMPEGGPYQQMLASGGIERATLDFDDLPEPVRLKTGIELPS
VTLARLREHER

Download         Length: 276 bp

>AT38211 NZ_AP024248:972009-972284 [Mycobacterium intracellulare]
ATGTCTACGGTGGGCGTTCGTGAGCTGCGGCAGCGGGCCAGCGAACTCCTCCGTCGGGTCGAGGCCGGCGAGACGATCGA
GATCACCGACCGTGGTCGGCCTATCGCCCTTCTCTCGCCGATGCCGGAGGGCGGTCCGTACCAGCAGATGCTGGCAAGCG
GCGGGATCGAACGTGCGACGCTTGACTTTGATGACCTTCCCGAGCCGGTCCGACTCAAAACGGGTATCGAGCTGCCGTCC
GTGACGCTTGCGCGCCTGCGTGAGCACGAGCGTTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A1X1XV84

Antitoxin

Source ID Structure
AlphaFold DB A0A1X1XUZ3

References