Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/PIN-PHD
Location 832444..833111 Replicon chromosome
Accession NZ_AP024245
Organism Mycobacterium intracellulare strain M006

Toxin (Protein)


Gene name vapC Uniprot ID D5PE24
Locus tag JN196_RS04155 Protein ID WP_007168407.1
Coordinates 832719..833111 (+) Length 131 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID D5PE23
Locus tag JN196_RS04150 Protein ID WP_007168406.1
Coordinates 832444..832719 (+) Length 92 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
JN196_RS04115 827948..828274 - 327 WP_033711234.1 hypothetical protein -
JN196_RS04120 828264..828497 - 234 Protein_807 transposase -
JN196_RS04125 828503..829678 - 1176 Protein_808 ISL3 family transposase -
JN196_RS04130 829865..830497 - 633 Protein_809 DDE-type integrase/transposase/recombinase -
JN196_RS04135 830449..830589 - 141 WP_145958858.1 SDR family oxidoreductase -
JN196_RS04140 830633..831336 - 704 Protein_811 histidine phosphatase family protein -
JN196_RS04145 831419..832291 + 873 WP_007168405.1 MaoC family dehydratase N-terminal domain-containing protein -
JN196_RS04150 832444..832719 + 276 WP_007168406.1 type II toxin-antitoxin system Phd/YefM family antitoxin Antitoxin
JN196_RS04155 832719..833111 + 393 WP_007168407.1 type II toxin-antitoxin system VapC family toxin Toxin
JN196_RS04160 833259..834418 - 1160 Protein_815 trehalose-phosphatase -
JN196_RS04165 834460..835798 - 1339 Protein_816 DUF1298 domain-containing protein -
JN196_RS04170 836059..836181 - 123 Protein_817 IS1595 family transposase -
JN196_RS04175 836518..837852 + 1335 Protein_818 IS1182 family transposase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(4-119)

Antitoxin

Type II toxin-antitoxin system, antitoxin Phd/YefM

(1-45)


Sequences

Toxin        


Download         Length: 131 a.a.        Molecular weight: 14305.73 Da        Isoelectric Point: 10.5032

>T38201 WP_007168407.1 NZ_AP024245:832719-833111 [Mycobacterium intracellulare]
MAAIYLDSSAIVKLAVREPESDALRRYLRTRLPRVSSALARTEVMRALLHKGESARRAGRRALASLDLLRIDNRLLDLAG
GLLPIELRTLDAIHLATAQRLGMDLGRLCTYDDRMRDAAEALGMAVIAPS

Download         Length: 393 bp

>T38201 NZ_AP024245:832719-833111 [Mycobacterium intracellulare]
ATGGCGGCCATCTACCTGGACTCGTCCGCAATCGTCAAGCTTGCAGTTCGTGAGCCAGAGTCGGATGCGCTGCGTCGCTA
CCTTCGCACCCGGCTGCCGCGGGTGTCGAGTGCCCTTGCGCGGACGGAGGTCATGCGGGCTCTGCTCCACAAGGGTGAAT
CAGCCCGAAGAGCCGGACGCCGGGCGCTCGCGAGCCTAGACCTACTACGCATCGACAACCGATTGCTCGATCTTGCTGGT
GGGCTGCTGCCAATCGAGCTACGCACCCTCGATGCAATTCACCTGGCGACTGCCCAGCGGCTCGGCATGGATCTTGGCCG
GTTGTGCACTTACGACGACCGCATGCGCGACGCCGCCGAGGCGCTCGGCATGGCAGTGATTGCCCCGTCTTGA

Antitoxin


Download         Length: 92 a.a.        Molecular weight: 10150.63 Da        Isoelectric Point: 5.1881

>AT38201 WP_007168406.1 NZ_AP024245:832444-832719 [Mycobacterium intracellulare]
MSTVGVRELRQRASELLRRVEAGETIEITDRGRPIALLSPMPEGGPYQQMLASGGIERATLDFDDLPEPVRLKTGIELPS
VTLARLREHER

Download         Length: 276 bp

>AT38201 NZ_AP024245:832444-832719 [Mycobacterium intracellulare]
ATGTCTACGGTGGGCGTTCGTGAGCTGCGGCAGCGGGCCAGCGAACTCCTCCGTCGGGTCGAGGCCGGCGAGACGATCGA
GATCACCGACCGTGGTCGGCCTATCGCCCTTCTCTCGCCGATGCCGGAGGGCGGTCCGTACCAGCAGATGCTGGCAAGCG
GCGGGATCGAACGTGCGACGCTTGACTTTGATGACCTTCCCGAGCCGGTCCGACTCAAAACGGGTATCGAGCTGCCGTCC
GTGACGCTTGCGCGCCTGCGTGAGCACGAGCGTTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A1X1XV84

Antitoxin

Source ID Structure
AlphaFold DB A0A1X1XUZ3

References