Detailed information of TA system TA038198

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): vapBC/VapC-VapB
• Location: 1140680..1141244
• Replicon: chromosome
• Accession: NZ_AP024244
• Organism: Mycobacterium intracellulare strain M005

Toxin (Protein)

• Gene name: vapC
• Uniprot ID: H8IVI4
• Locus tag: JN195_RS05695
• Protein ID: WP_009953437.1
• Coordinates: 1140873..1141244 (+)
• Length: 124 a.a.

Antitoxin (Protein)

• Gene name: vapB
• Uniprot ID: -
• Locus tag: JN195_RS05690
• Protein ID: WP_026071432.1
• Coordinates: 1140680..1140886 (+)
• Length: 69 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
JN195_RS05670	1136301..1137299	+	999	WP_008254378.1	4-hydroxy-3-methylbut-2-enyl diphosphate reductase	-
JN195_RS05675	1137345..1138484	-	1140	WP_179300624.1	hypothetical protein	-
JN195_RS05680	1138626..1139699	+	1074	WP_009953440.1	redox-regulated ATPase YchF	-
JN195_RS05685	1139779..1140441	-	663	WP_014379386.1	methyltransferase domain-containing protein	-
JN195_RS05690	1140680..1140886	+	207	WP_026071432.1	type II toxin-antitoxin system VapB family antitoxin	Antitoxin
JN195_RS05695	1140873..1141244	+	372	WP_009953437.1	type II toxin-antitoxin system VapC family toxin	Toxin
JN195_RS05700	1141302..1141853	+	552	WP_009953436.1	VOC family protein	-
JN195_RS05705	1141932..1142330	+	399	WP_009953435.1	VOC family protein	-
JN195_RS05710	1142429..1142812	+	384	WP_026071433.1	hypothetical protein	-
JN195_RS05715	1142898..1143257	+	360	WP_198139476.1	hypothetical protein	-
JN195_RS05720	1143439..1144014	+	576	WP_085977620.1	C40 family peptidase	-
JN195_RS05725	1144377..1144700	+	324	WP_009953431.1	antibiotic biosynthesis monooxygenase	-
JN195_RS05730	1144749..1145432	-	684	WP_014384004.1	hypothetical protein	-
JN195_RS05735	1145579..1145788	+	210	WP_014381976.1	hypothetical protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• PIN domain (2-112)

Antitoxin

• Bacterial antitoxin of type II TA system, VapB (1-42)

Sequences

Toxin

Protein

• Length: 124 a.a.
• Molecular weight: 13868.20 Da
• Isoelectric Point: 6.8398

>T38198 WP_009953437.1 NZ_AP024244:1140873-1141244 [Mycobacterium intracellulare]
VILVDTSIWIDHLHVAEQRLVGRLTNDEIGCHQMVIEELALGMIKQRDDVLRLLSHLREFPLLTHAEILHLVDRRRLWGR
GLSAIDAHLLGSVAVVDGARLWTRDKKLKAACKEVGVAIVDES

Nucleotide

• Length: 372 bp

>T38198 NZ_AP024244:1140873-1141244 [Mycobacterium intracellulare]
GTGATCCTCGTTGACACATCGATATGGATTGACCATCTGCACGTCGCCGAGCAGCGCCTCGTCGGCCGCTTGACCAACGA
CGAAATCGGTTGCCACCAAATGGTGATCGAGGAGCTGGCACTCGGTATGATCAAGCAGCGCGACGACGTACTGAGATTGC
TGTCCCATCTGCGCGAGTTTCCGTTGTTGACGCACGCGGAAATCCTCCATCTCGTTGACCGTCGCCGCTTGTGGGGAAGG
GGATTGAGTGCAATCGACGCCCACCTTCTTGGGTCGGTTGCTGTCGTCGACGGTGCACGGCTTTGGACGAGGGACAAGAA
GTTGAAAGCGGCGTGTAAAGAAGTGGGTGTTGCGATCGTCGATGAGTCGTGA

Antitoxin

Protein

• Length: 69 a.a.
• Molecular weight: 7250.31 Da
• Isoelectric Point: 11.9169

>AT38198 WP_026071432.1 NZ_AP024244:1140680-1140886 [Mycobacterium intracellulare]
MRTTVTIDDALLAQAAELTGVTESAALLRQGLQTLIRVESARRLAALGGTDPKASAAPRRRPPTRDPR

Nucleotide

• Length: 207 bp

>AT38198 NZ_AP024244:1140680-1140886 [Mycobacterium intracellulare]
ATGAGGACAACAGTGACCATCGACGATGCCTTACTGGCTCAGGCGGCGGAACTGACCGGCGTGACGGAGAGTGCGGCGCT
TCTCCGTCAGGGATTGCAGACCCTCATTCGGGTAGAGAGCGCCCGCCGTCTCGCGGCGCTCGGCGGCACGGACCCCAAGG
CGTCGGCCGCCCCGCGGCGGAGGCCGCCGACCCGTGATCCTCGTTGA

Structures

Toxin

• AlphaFold DB: A0A7R7MQX9