Detailed information of TA system TA038196

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): pezAT/zeta-ParD
• Location: 2538729..2539721
• Replicon: chromosome
• Accession: NZ_AP024243
• Organism: Mycobacterium paraintracellulare strain M003

Toxin (Protein)

• Gene name: pezT
• Uniprot ID: J9WIQ3
• Locus tag: JN214_RS11745
• Protein ID: WP_014941867.1
• Coordinates: 2539143..2539721 (+)
• Length: 193 a.a.

Antitoxin (Protein)

• Gene name: pezA
• Uniprot ID: J9WGA7
• Locus tag: JN214_RS11740
• Protein ID: WP_014941866.1
• Coordinates: 2538729..2539118 (+)
• Length: 130 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
JN214_RS11715	2534180..2536183	+	2004	WP_014384640.1	phosphotransferase	-
JN214_RS11720	2536180..2536680	+	501	WP_014384641.1	gluconokinase	-
JN214_RS11725	2536751..2537362	-	612	WP_009956383.1	TetR/AcrR family transcriptional regulator	-
JN214_RS11730	2537532..2538356	+	825	WP_080588061.1	SAM-dependent methyltransferase	-
JN214_RS11735	2538396..2538671	+	276	WP_038536176.1	hypothetical protein	-
JN214_RS11740	2538729..2539118	+	390	WP_014941866.1	hypothetical protein	Antitoxin
JN214_RS11745	2539143..2539721	+	579	WP_014941867.1	zeta toxin family protein	Toxin
JN214_RS11750	2539741..2540808	-	1068	WP_014380064.1	DoxX family membrane protein	-
JN214_RS11755	2540904..2541464	+	561	WP_158020468.1	pyrazinamidase PncA	-
JN214_RS11760	2541464..2542264	+	801	WP_009956375.1	nuclear transport factor 2 family protein	-
JN214_RS11765	2542276..2542626	-	351	WP_009956374.1	DoxX family protein	-
JN214_RS11770	2542792..2543763	+	972	WP_014941870.1	sigma-70 family RNA polymerase sigma factor	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Zeta toxin domain (4-138)

Antitoxin

• ParD-like antitoxin of type II bacterial toxin-antitoxin system (6-106)

Sequences

Toxin

Protein

• Length: 193 a.a.
• Molecular weight: 21005.20 Da
• Isoelectric Point: 11.0232

>T38196 WP_014941867.1 NZ_AP024243:2539143-2539721 [Mycobacterium paraintracellulare]
MQRLDLVVGPNGAGKSTFIAFTLAPLLPGSPVVNADEIARQRWPGDAAGRAYDAAQIAAATRAKLIDLGRSFIAETVFSH
PSKLDLIRTALRAGFTVVLHAMLIPEDLAVERVRHRVRAGGHDVPETKVRERHRRLWTPVTDAIALSDVATVYDNGRLRG
PRIVARLSGGMIIGSPDWPAWAPEILRSRWPD

Nucleotide

• Length: 579 bp

>T38196 NZ_AP024243:2539143-2539721 [Mycobacterium paraintracellulare]
ATGCAGCGACTTGACCTGGTGGTCGGGCCGAACGGTGCCGGCAAGTCGACCTTCATCGCGTTCACGCTGGCGCCGCTGTT
GCCCGGCAGCCCGGTCGTCAACGCCGATGAGATCGCAAGGCAGCGCTGGCCGGGGGATGCGGCGGGGCGCGCCTACGACG
CCGCGCAAATCGCCGCCGCCACGCGCGCGAAGTTGATCGACCTGGGGCGGTCGTTCATCGCGGAGACCGTGTTTTCCCAC
CCGTCGAAGCTGGACCTCATCCGCACCGCCCTCCGAGCGGGCTTCACCGTCGTCCTGCACGCGATGCTCATCCCGGAAGA
CCTTGCCGTCGAACGTGTCCGGCACCGCGTGCGGGCCGGCGGCCACGACGTACCGGAAACCAAGGTTCGCGAGCGCCATC
GTCGCTTGTGGACACCGGTCACCGACGCCATCGCGCTTTCCGACGTCGCCACCGTCTACGACAACGGCCGGCTGCGCGGG
CCGCGCATTGTCGCCCGCCTCAGCGGCGGCATGATTATCGGTTCACCGGACTGGCCGGCGTGGGCTCCGGAGATCTTGCG
GTCGCGCTGGCCGGACTAG

Antitoxin

Protein

• Length: 130 a.a.
• Molecular weight: 13484.84 Da
• Isoelectric Point: 5.1743

>AT38196 WP_014941866.1 NZ_AP024243:2538729-2539118 [Mycobacterium paraintracellulare]
MADAPDRVTRVASDLMDSAASEGARQSRSAKQQLDHWARVGRAVSSQHTASRRRVEAALAGQLATGELTVEEGVVFNAEV
SAAIDESLVHADYGATLAGHGVTTVALNEDGDIVEHRPDGAAVVLARGR

Nucleotide

• Length: 390 bp

>AT38196 NZ_AP024243:2538729-2539118 [Mycobacterium paraintracellulare]
ATGGCCGACGCTCCCGATCGTGTGACCCGCGTGGCGTCCGACCTGATGGACAGCGCGGCCTCCGAAGGCGCCCGCCAGAG
CCGTTCGGCCAAGCAGCAACTCGACCACTGGGCGCGTGTCGGGCGCGCGGTGTCCAGCCAGCACACCGCCTCGCGTCGGC
GGGTCGAGGCCGCGCTGGCCGGCCAGCTGGCGACCGGCGAACTCACCGTCGAGGAAGGCGTGGTGTTCAACGCCGAGGTC
TCCGCGGCCATCGACGAAAGCCTGGTGCACGCCGACTACGGGGCGACGCTGGCCGGGCATGGCGTCACCACGGTCGCCCT
CAACGAGGACGGCGACATCGTCGAGCACCGGCCCGACGGCGCCGCCGTGGTGCTGGCGCGCGGGCGCTGA

Structures

Toxin

• AlphaFold DB: J9WIQ3

Antitoxin

• AlphaFold DB: J9WGA7