38189

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/VapC-VapB
Location 1186903..1187467 Replicon chromosome
Accession NZ_AP024241
Organism Mycobacterium intracellulare strain M002

Toxin (Protein)


Gene name vapC Uniprot ID -
Locus tag JN194_RS05925 Protein ID WP_036458315.1
Coordinates 1187096..1187467 (+) Length 124 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID -
Locus tag JN194_RS05920 Protein ID WP_036458377.1
Coordinates 1186903..1187109 (+) Length 69 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
JN194_RS05900 1182518..1183516 + 999 WP_008254378.1 4-hydroxy-3-methylbut-2-enyl diphosphate reductase -
JN194_RS05905 1183562..1184707 - 1146 WP_196233638.1 hypothetical protein -
JN194_RS05910 1184849..1185922 + 1074 WP_036458307.1 redox-regulated ATPase YchF -
JN194_RS05915 1186002..1186664 - 663 WP_036458309.1 methyltransferase domain-containing protein -
JN194_RS05920 1186903..1187109 + 207 WP_036458377.1 type II toxin-antitoxin system VapB family antitoxin Antitoxin
JN194_RS05925 1187096..1187467 + 372 WP_036458315.1 type II toxin-antitoxin system VapC family toxin Toxin
JN194_RS05930 1187525..1188076 + 552 WP_038535279.1 VOC family protein -
JN194_RS05935 1188155..1188553 + 399 WP_009953435.1 VOC family protein -
JN194_RS05940 1188653..1189036 + 384 WP_196233639.1 hypothetical protein -
JN194_RS05945 1189110..1189454 - 345 WP_036458317.1 hypothetical protein -
JN194_RS05950 1189664..1190239 + 576 WP_136245571.1 C40 family peptidase -
JN194_RS05955 1190603..1190926 + 324 WP_009953431.1 antibiotic biosynthesis monooxygenase -
JN194_RS05960 1190974..1191657 - 684 WP_036458379.1 hypothetical protein -
JN194_RS05965 1191804..1192013 + 210 WP_080687320.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(2-111)

Antitoxin

Bacterial antitoxin of type II TA system, VapB

(1-42)


Sequences

Toxin        


Download         Length: 124 a.a.        Molecular weight: 13905.22 Da        Isoelectric Point: 6.9118

>T38189 WP_036458315.1 NZ_AP024241:1187096-1187467 [Mycobacterium intracellulare]
VILVDTSIWIDHLHVAEHRLVGRLTNDEIGCHQMVIEELALGMIKQRDDVLRLLSHLREFPLLTHAEILHLVDRRRLWGR
GLSAIDAHLLGSVAVVDGARLWTRDKKLKAACREVGVAIVDES

Download         Length: 372 bp

>T38189 NZ_AP024241:1187096-1187467 [Mycobacterium intracellulare]
GTGATCCTCGTTGACACATCGATATGGATTGACCATCTGCACGTCGCCGAGCATCGCCTCGTCGGCCGCTTGACCAACGA
CGAAATCGGTTGCCACCAAATGGTGATCGAGGAGCTGGCACTCGGTATGATCAAGCAGCGCGACGACGTACTGAGATTGC
TGTCCCATCTGCGCGAGTTTCCGTTGTTGACGCACGCGGAAATCCTCCATCTCGTTGACCGTCGCCGCTTGTGGGGAAGG
GGATTGAGCGCAATCGACGCCCACCTTCTTGGGTCGGTTGCTGTCGTCGACGGTGCACGGCTTTGGACGAGGGACAAGAA
GTTGAAAGCGGCGTGTAGAGAAGTGGGCGTTGCGATCGTCGATGAGTCGTGA

Antitoxin


Download         Length: 69 a.a.        Molecular weight: 7220.29 Da        Isoelectric Point: 11.9169

>AT38189 WP_036458377.1 NZ_AP024241:1186903-1187109 [Mycobacterium intracellulare]
MRTTVTIDDALLAQAAELTGVAESAALLRQGLQTLIRVESARRLAALGGTDPKASAAPRRRPPTRDPR

Download         Length: 207 bp

>AT38189 NZ_AP024241:1186903-1187109 [Mycobacterium intracellulare]
ATGAGGACAACAGTGACCATCGACGATGCCTTACTGGCTCAGGCGGCGGAACTGACCGGCGTGGCGGAGAGTGCGGCGCT
TCTCCGTCAGGGATTGCAGACCCTCATTCGGGTAGAGAGCGCCCGCCGTCTCGCGGCGCTCGGCGGCACGGACCCCAAGG
CGTCGGCCGCCCCGCGGCGGAGGCCGCCGACCCGTGATCCTCGTTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References