Detailed information of TA system TA038187

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): vapBC/PIN-PHD
• Location: 708275..708942
• Replicon: chromosome
• Accession: NZ_AP024241
• Organism: Mycobacterium intracellulare strain M002

Toxin (Protein)

• Gene name: vapC
• Uniprot ID: D5PE24
• Locus tag: JN194_RS03615
• Protein ID: WP_007168407.1
• Coordinates: 708550..708942 (+)
• Length: 131 a.a.

Antitoxin (Protein)

• Gene name: vapB
• Uniprot ID: D5PE23
• Locus tag: JN194_RS03610
• Protein ID: WP_007168406.1
• Coordinates: 708275..708550 (+)
• Length: 92 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
JN194_RS03575	703779..704105	-	327	WP_033711234.1	hypothetical protein	-
JN194_RS03580	704095..704328	-	234	Protein_699	transposase	-
JN194_RS03585	704334..705509	-	1176	Protein_700	ISL3 family transposase	-
JN194_RS03590	705696..706328	-	633	Protein_701	DDE-type integrase/transposase/recombinase	-
JN194_RS03595	706280..706420	-	141	WP_145958858.1	SDR family oxidoreductase	-
JN194_RS03600	706464..707167	-	704	Protein_703	histidine phosphatase family protein	-
JN194_RS03605	707250..708122	+	873	WP_007168405.1	MaoC family dehydratase N-terminal domain-containing protein	-
JN194_RS03610	708275..708550	+	276	WP_007168406.1	type II toxin-antitoxin system Phd/YefM family antitoxin	Antitoxin
JN194_RS03615	708550..708942	+	393	WP_007168407.1	type II toxin-antitoxin system VapC family toxin	Toxin
JN194_RS03620	709090..710249	-	1160	Protein_707	trehalose-phosphatase	-
JN194_RS03625	710291..711629	-	1339	Protein_708	DUF1298 domain-containing protein	-
JN194_RS03630	711890..712012	-	123	Protein_709	IS1595 family transposase	-
JN194_RS03635	712349..713683	+	1335	Protein_710	IS1182 family transposase	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Genomic island	-	-	674056..741344	67288

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• PIN domain (4-119)

Antitoxin

• Type II toxin-antitoxin system, antitoxin Phd/YefM (1-45)

Sequences

Toxin

Protein

• Length: 131 a.a.
• Molecular weight: 14305.73 Da
• Isoelectric Point: 10.5032

>T38187 WP_007168407.1 NZ_AP024241:708550-708942 [Mycobacterium intracellulare]
MAAIYLDSSAIVKLAVREPESDALRRYLRTRLPRVSSALARTEVMRALLHKGESARRAGRRALASLDLLRIDNRLLDLAG
GLLPIELRTLDAIHLATAQRLGMDLGRLCTYDDRMRDAAEALGMAVIAPS

Nucleotide

• Length: 393 bp

>T38187 NZ_AP024241:708550-708942 [Mycobacterium intracellulare]
ATGGCGGCCATCTACCTGGACTCGTCCGCAATCGTCAAGCTTGCAGTTCGTGAGCCAGAGTCGGATGCGCTGCGTCGCTA
CCTTCGCACCCGGCTGCCGCGGGTGTCGAGTGCCCTTGCGCGGACGGAGGTCATGCGGGCTCTGCTCCACAAGGGTGAAT
CAGCCCGAAGAGCCGGACGCCGGGCGCTCGCGAGCCTAGACCTACTACGCATCGACAACCGATTGCTCGATCTTGCTGGT
GGGCTGCTGCCAATCGAGCTACGCACCCTCGATGCAATTCACCTGGCGACTGCCCAGCGGCTCGGCATGGATCTTGGCCG
GTTGTGCACTTACGACGACCGCATGCGCGACGCCGCCGAGGCGCTCGGCATGGCAGTGATTGCCCCGTCTTGA

Antitoxin

Protein

• Length: 92 a.a.
• Molecular weight: 10150.63 Da
• Isoelectric Point: 5.1881

>AT38187 WP_007168406.1 NZ_AP024241:708275-708550 [Mycobacterium intracellulare]
MSTVGVRELRQRASELLRRVEAGETIEITDRGRPIALLSPMPEGGPYQQMLASGGIERATLDFDDLPEPVRLKTGIELPS
VTLARLREHER

Nucleotide

• Length: 276 bp

>AT38187 NZ_AP024241:708275-708550 [Mycobacterium intracellulare]
ATGTCTACGGTGGGCGTTCGTGAGCTGCGGCAGCGGGCCAGCGAACTCCTCCGTCGGGTCGAGGCCGGCGAGACGATCGA
GATCACCGACCGTGGTCGGCCTATCGCCCTTCTCTCGCCGATGCCGGAGGGCGGTCCGTACCAGCAGATGCTGGCAAGCG
GCGGGATCGAACGTGCGACGCTTGACTTTGATGACCTTCCCGAGCCGGTCCGACTCAAAACGGGTATCGAGCTGCCGTCC
GTGACGCTTGCGCGCCTGCGTGAGCACGAGCGTTGA

Structures

Toxin

• AlphaFold DB: A0A1X1XV84

Antitoxin

• AlphaFold DB: A0A1X1XUZ3